Comparing the Characteristics of Patients With Newly Diagnosed Dementia Before and After 2008 in Seoul, South Korea: A Population-Based Study

Kwon, Hyuk Sung; Jeong, Yong Whi; Park, So Jeong; Kang, Dae Ryong; Choi, Hojin

doi:10.3988/jcn.2022.18.6.711

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Those who died before March 31, 2019, for whom the period corresponding to the polypharmacy definition criteria (see the Variables section) could not be observed, were excluded from the study. Based on previous definitions in similar studies [ 33 , 34 , 38 ], patients with dementia were identified as those who received at least one treatment with the primary or secondary disease codes F00, F01, F02, F03, G30, G31.82 (Korean Standard Classification of Diseases and Causes of Death-7; KCD-7; S1 Table ), or those who were prescribed dementia medication (donepezil, galantamine, rivastigmine, and memantine) at least once in 2019. These criteria included not only patients with Alzheimer’s disease, vascular dementia, and dementia in other diseases, but also patients taking dementia medication without the aforementioned disease code.…”

Section: Methodsmentioning

confidence: 99%

Polypharmacy and associated factors in South Korean elderly patients with dementia: An analysis using National Health Insurance claims data

Kim,

Lee

2024

PLoS ONE

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Background Dementia is accompanied by several symptoms, including cognitive function decline, as well as behavioral and psychological symptoms. Elderly patients with dementia often experience polypharmacy, the concurrent use of multiple medications, due to chronic comorbidities. However, research on polypharmacy in patients with dementia is limited. This study aimed to characterize polypharmacy and associated factors among elderly patients with dementia in South Korea, and compare the characteristics of patients with and without dementia patients. Methods From the National Health Insurance Service (NHIS)-Senior cohort database, we extracted data on patients aged≥60 years who received outpatient treatment in 2019. Polypharmacy was defined as the concurrent use of five or more different oral medications for ≥90 days; excessive polypharmacy referred to the concurrent use of ten or more different oral medications for ≥90 days. We compared the prevalence of polypharmacy between patients with and without and identified the associated factors using a logistic regression model. Results About 70.3% and 23.7% of patients with dementia exhibited polypharmacy and excessive polypharmacy, respectively. After adjusting for conditions such as age and Charlson’s comorbidity index, the likelihood of polypharmacy and excessive polypharmacy significantly increased over time after the diagnosis of dementia. Additionally, under the same conditions, Medical Aid beneficiaries with dementia were more likely to experience polypharmacy and excessive polypharmacy compared to patients with dementia covered by National Health Insurance (NHI). Conclusion This study reports the latest evidence on the status and risk factors of polypharmacy in elderly patients with dementia. We proposed that careful monitoring and management are required for patients at high risk for polypharmacy.

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Section: Methodsmentioning

confidence: 99%

Polypharmacy and associated factors in South Korean elderly patients with dementia: An analysis using National Health Insurance claims data

Kim,

Lee

2024

PLoS ONE

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“…Policies for monitoring patients with dementia commonly rely on epidemiological data to identify vulnerable groups, including those of higher age, lower socioeconomic status, and having specific dementia types. 6 Despite these efforts, evaluating the effectiveness of dementia management remains challenging. Therefore, a new indicator called the community management rate was analyzed previously.…”

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confidence: 99%

Monitoring Patients With Dementia: Insight Into Global Trends, Innovations, and Future Directions

Kwon,

Koh

2024

J Clin Neurol

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Impact of the COVID-19 pandemic on mortality and loss to follow-up among patients with dementia receiving anti-dementia medications

Kwon,

Sung,

Park

et al. 2024

Sci Rep

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The coronavirus disease 2019 (COVID-19) pandemic has profoundly impacted vulnerable groups, such as patients with dementia. We examined changes in mortality and loss to follow-up in patients with dementia using data from the Korean National Health Insurance Service research database. Patients with dementia who visited a medical institution with a recorded dementia-related diagnostic code, including Alzheimer’s disease, and who received anti-dementia medication between February 2018 and January 2020 were included in this study. We divided patients with dementia receiving anti-dementia medications into two cohorts: those newly diagnosed with dementia between February 2018 and January 2019 (n = 62,631) and those diagnosed between February 2019 and January 2020 (n = 54,494). Then, we conducted a one-year follow-up of their records, tracking the cohort diagnosed between February 2018 and January 2019 from February 2019 to January 2020, as well as the cohort diagnosed between February 2019 and January 2020 from February 2020 to January 2021. There was a significant increase in follow-up loss among patients newly diagnosed with dementia during the COVID-19 outbreak, from 42.04% in 2019 to 45.89% in 2020. Female sex, younger age, fewer comorbidities, diagnosis of dementia at the Department of Neurology or Psychiatry, and higher income were associated with decreased follow-up loss and mortality. This study highlights the importance of paying extra attention to patients with dementia receiving anti-dementia medications, particularly during pandemics, given their increased risk of loss to follow-up.

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Comparing the Characteristics of Patients With Newly Diagnosed Dementia Before and After 2008 in Seoul, South Korea: A Population-Based Study

Cited by 4 publications

References 6 publications

Polypharmacy and associated factors in South Korean elderly patients with dementia: An analysis using National Health Insurance claims data

Polypharmacy and associated factors in South Korean elderly patients with dementia: An analysis using National Health Insurance claims data

Monitoring Patients With Dementia: Insight Into Global Trends, Innovations, and Future Directions

Impact of the COVID-19 pandemic on mortality and loss to follow-up among patients with dementia receiving anti-dementia medications

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