Comparing the Compressibility of Ludipress with the Other Direct Tableting Agents by Using Acetaminophen as an Active Ingredient

Baykara, Tamer; Duman, Gökhan; Özşener, K. Ş.; S, Ordu; B, Ozates

doi:10.3109/03639049109048080

Cited by 15 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has a lower compactibility (160 N) than Cellactose® (180 N), but larger than that of Avicel® PH-200, Tablettose® and its physical blend (140 N, 90 N and 60 N, respectively 27 ). It also shows a lower yield pressure than that of Avicel® PH-102 (86 vs 49 MPa, respectively) and it also has good tableting characteristics for low dose APIs such as glibenclimide (2 mg) and its hardness is not affected by tableting speed 32 . It also exhibits better flowability than Cellactose® Tablettose® and Avicel® PH-200 (angle of repose of 31°, 36°, 36° and 36°, respectively 27,33 ).…”

Section: Lactose-pvp (Ludipress®)mentioning

confidence: 99%

Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance

Rojas

Buckner

Kumar

2012

Drug Development and Industrial Pharmacy

101

View full text Add to dashboard Cite

It is necessary to have excipients with excellent functional properties to compensate for the poor mechanical properties and low aqueous solubility of the emerging active ingredients. Therefore, around 80% of the current drugs are not suitable for direct compression and more advanced excipients are required. Further, conventional grades of excipients cannot accommodate the technologically advanced high speed rotary tablet presses which require a powder with excellent flow, good compressibility, compactibility, particle size distribution and homogeneity of the ingredients. Co-processed excipients have been created to enhance the functional properties of the excipients and reduce their drawbacks. Co-processing is defined as the combination of two or more excipients by a physical process. Co-processed excipients are adequate for direct compression since they become multifunctional and thus, their dilution potential is high eliminating the need for many excipients in a formulation. In some cases, they are able to hold up to 50% of the drug in a formulation rendering compacts of good tableting properties. This study describes and discusses the functionality enhancement of commercial and investigational excipients through co-processing.

show abstract

Section: Lactose-pvp (Ludipress®)mentioning

confidence: 99%

Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance

Rojas

Buckner

Kumar

2012

Drug Development and Industrial Pharmacy

101

View full text Add to dashboard Cite

show abstract

“…This is evidence that the consolidation of powder mass was influenced negatively by an uncontrolled alteration in the size and distribution of the particles. The declined slope in consolidation results in an increase of the punch distance and in uncontrolled changes in compressing properties of the tablets (2,12). The consolidation relationship between UFR and FR is shown in Fig.…”

Section: Resultsmentioning

confidence: 97%

Kinetic Evaluation of the Mechanical Strength of Briquette Granules

Bozkır

Özdemir

Özyurt

et al. 1997

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

The mechanical strength of the granules is dejined by the friability index (FI). This index describes the condition at the end of a certain time period. However, the mixing process during industrial manufacturing displays a continuity that changes as a function of time. In this study, the mechanical strength of a briquette granule composed of a mixture of lactose, microcrystalline cellulose, and microjine cellulose, and obtained by the dry granulation (slugging) method was examined as a function of its duration of friability. In addition, the effect of the length of friability period on the physicopharmaceutical and compression properties of the briquette granules was observed. It was found that the friability event in the briquette granules occurs as an inteiparticular milling instead of as a breakdown of the binding bridges as in the wet granulation method, and that compressibility and other properties change to inte?jfere with the validity of the process. ratio of the mean particle size of pulverized granules (FR) to the mean particle size of the unpulverized granules (UFR). If no erosion occurs during the test, no

show abstract

“…At low compression pressure Ludipress ® gives harder tablets and although contains disintegrant, the disintegration take more time than tablets containing Tablettose ® and it is reported that binding capacity of it was higher than microcrystalline cellulose. Dilution potential of Ludipress ® is differed with different drugs (4,6,(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…is the applied pressure (MPa), K is a constant determined from the slope and A from the intercept of a plot of ln(1/1-D) vs. P( 8,14,(21)(22)(23)(24).…”

mentioning

confidence: 99%

Investigation on the flow properties and compresibilities of different direct tableting agents by using pyridoxine hydrochloride as a model drug

ÇAMCA¹

2009

Ankara Universitesi Eczacilik Fakultesi Dergisi

View full text Add to dashboard Cite

The purpose of this study was to evaluate the flow properties and compressibilities of different direct tableting agents (DTA) by using pyridoxine hydrochloride as a model drug. Avicel PH 102 ® , Tablettose 100 ® , StarLac ® and Ludipress ® were used as DTAs. Flow rate, angle of repose, bulk and tapped densities of DTAs, binary mixture of drug and DTA and mixtures of drug-DTA-magnesium stearate were examined. Carr's index and Hausner index were calculated to determine the consolidation character of powder mixtures. Tablets were compressed at different pressure by a manual hydraulic press. Heckel and Kawakita equations were fitted to the data obtained from compressibility studies. StarLac ® and Ludipress ® showed good flow properties as indicated by the lowest angle of repose and the highest flow rate. The Hausner and Carr's index values of these agents were in the range of good flow characteristic values according to the pharmacopoeial limits. The lowest Py values of powder mixture prepared with StarLac ® or Ludipress ® were also pointed out of acceptable compressibility. When Tablettose ® was used in the formulation, capping and lamination problems were occurred at the higher compression pressure. The effect of the increased percent amount of drug (12% to 36%) on the consolidation properties and compressibility was also determined at the Müge KILIÇARSLAN, Rüya ÇAMCA, Selin ĐMAMOĞLU, Mustafa Naim ANTEP, Başak OCAK, Nilüfer YÜKSEL 332 formulations prepared with Ludipress ®. Optimum consolidation and compressibility characters were obtained by 18% drug while more than 24% drug amount was caused to decreased volume reduction.

show abstract

Comparing the Compressibility of Ludipress with the Other Direct Tableting Agents by Using Acetaminophen as an Active Ingredient

Cited by 15 publications

References 2 publications

Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance

Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance

Kinetic Evaluation of the Mechanical Strength of Briquette Granules

Investigation on the flow properties and compresibilities of different direct tableting agents by using pyridoxine hydrochloride as a model drug

Contact Info

Product

Resources

About