Comparing the effect of induction therapy with or without antithymocyte globulin on renal allograft outcomes in live-donor kidney transplant recipients

Marghoob, Bahareh; Rahimian, Neda; Ataiepour, Yousef; Mahdifarani, Marziyeh; Nejatifar, Masoumeh; Kabir, Ali

doi:10.47176/mjiri.33.141

Cited by 1 publication

(1 citation statement)

References 18 publications

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“…For VCAs, recent research has shed light on the primary targets of rejection reactions, identifying the mucosa ( 20 ) and skin ( 21 ) as key areas of concern. Induction therapy, akin to SOTs, is frequently based on ATG ( 22 ). Despite the adoption of SOT triple therapy as the standard maintenance regimen for the majority of VCA patients, the occurrence of acute rejection within the first-year post-transplant remains high, exceeding 80% ( 23 ).…”

Section: Perioperative Standard Pharmacological Therapy In Transplant...mentioning

confidence: 99%

Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions

Knoedler,

Dean,

Diatta

et al. 2024

Front. Immunol.

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Balancing the immune response after solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) remains an ongoing clinical challenge. While immunosuppressants can effectively reduce acute rejection rates following transplant surgery, some patients still experience recurrent acute rejection episodes, which in turn may progress to chronic rejection. Furthermore, these immunosuppressive regimens are associated with an increased risk of malignancies and metabolic disorders. Despite significant advancements in the field, these IS related side effects persist as clinical hurdles, emphasizing the need for innovative therapeutic strategies to improve transplant survival and longevity. Cellular therapy, a novel therapeutic approach, has emerged as a potential pathway to promote immune tolerance while minimizing systemic side-effects of standard IS regiments. Various cell types, including chimeric antigen receptor T cells (CAR-T), mesenchymal stromal cells (MSCs), regulatory myeloid cells (RMCs) and regulatory T cells (Tregs), offer unique immunomodulatory properties that may help achieve improved outcomes in transplant patients. This review aims to elucidate the role of cellular therapies, particularly MSCs, T cells, Tregs, RMCs, macrophages, and dendritic cells in SOT and VCA. We explore the immunological features of each cell type, their capacity for immune regulation, and the prospective advantages and obstacles linked to their application in transplant patients. An in-depth outline of the current state of the technology may help SOT and VCA providers refine their perioperative treatment strategies while laying the foundation for further trials that investigate cellular therapeutics in transplantation surgery.

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Section: Perioperative Standard Pharmacological Therapy In Transplant...mentioning

confidence: 99%

Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions

Knoedler,

Dean,

Diatta

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

Comparing the effect of induction therapy with or without antithymocyte globulin on renal allograft outcomes in live-donor kidney transplant recipients

Cited by 1 publication

References 18 publications

Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions

Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions

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