2016
DOI: 10.1089/wound.2015.0683
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Comparing the Effectiveness of Polymer Debriding Devices Using a Porcine Wound Biofilm Model

Abstract: Objective: Debridement to remove necrotic and/or infected tissue and promote active healing remains a cornerstone of contemporary chronic wound management. While there has been a recent shift toward less invasive polymer-based debriding devices, their efficacy requires rigorous evaluation.Approach: This study was designed to directly compare monofilament debriding devices to traditional gauze using a wounded porcine skin biofilm model with standardized application parameters. Biofilm removal was determined usi… Show more

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Cited by 20 publications
(23 citation statements)
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“…Data generated indicate that (i) plaque removal by standardized brushing regimens could be visualized and quantified; (ii) that plaque removal was significantly augmented by the addition of a toothpaste; and (iii) that brush head wear significantly reduced the effectiveness of brushes for the removal of biofilms developed from mixed oral bacteria. Whilst we have focussed on the occlusal surfaces of molars, the method could be applied other tooth surfaces and materials, and could incorporate the use of a viability indicator (50) to assess both plaque removal and bacterial inactivation. The model system, applying toothpastes at in-use concentrations may have advantages over in vitro methods that use lower concentrations since concentration exponents of antimicrobial compounds can vary markedly (51) and physical and antibacterial effects could be assessed concomitantly.…”
Section: Resultsmentioning
confidence: 99%
“…Data generated indicate that (i) plaque removal by standardized brushing regimens could be visualized and quantified; (ii) that plaque removal was significantly augmented by the addition of a toothpaste; and (iii) that brush head wear significantly reduced the effectiveness of brushes for the removal of biofilms developed from mixed oral bacteria. Whilst we have focussed on the occlusal surfaces of molars, the method could be applied other tooth surfaces and materials, and could incorporate the use of a viability indicator (50) to assess both plaque removal and bacterial inactivation. The model system, applying toothpastes at in-use concentrations may have advantages over in vitro methods that use lower concentrations since concentration exponents of antimicrobial compounds can vary markedly (51) and physical and antibacterial effects could be assessed concomitantly.…”
Section: Resultsmentioning
confidence: 99%
“…Wound management begins with an assessment of wound aetiology and a patient-centric approach to managing systemic and lifestyle factors. In the case of diabetic foot ulcers, local management often starts with debridement, the removal of necrotic, infected or hyperkeratotic tissue via surgical or less invasive modalities [ 5 , 199 ]. Extracting the chronic tissue back to less affected epidermis, while triggering an acute injury response, is thought to kick-start normal reparative healing pathways [ 200 ].…”
Section: Current Therapies and Future Opportunitiesmentioning
confidence: 99%
“…Scanning electron microscopy (SEM) provides high resolution morphological and structural characterisation of the biofilm 7 . Epifluorescent microscopy can be used to visualise micro-colony formation and also quantify biofilm viability using fluorescent live/dead stains or selective probes that target bacteria specific gene sequences 8 . Other techniques include but are not limited to enumeration, colorimetric methods, metabolic and biomass assays 9 .…”
Section: Introductionmentioning
confidence: 99%