Comparing the Effects of Dexmedetomidine and Midazolam on Sedation in Children with Head Trauma to Perform CT in Emergency Department / Upoređivanje efekata deksmedetomidina i midazolama na sedaciju dece sa povredom glave radi snimanja CT-om na Odeljenju urgentne medicine
Abstract:Many of the children referred to the emergency complain of head trauma. Children usually require sedition to reduce their failure and fear because of high activity and fear of performing computed tomography (CT). Dexmedetomidine and Midazolam belong to short-acting drugs for this purpose. This study aimed to compare the effect of the above mentioned drugs on sedition in children.Children referred to the emergency department were randomly divided into two groups. Group A was sedated with 0.05 mg/kg IV Midazolam… Show more
“…Study designs included 11 RCTs, 22,32–41 13 cohort studies and other nonrandomized studies, 19–21,23,42–50 and 11 case series and case reports 12,51–60 . Six of the included studies were conference abstracts 20,21,40,47,50,56 .…”
Section: Resultsmentioning
confidence: 99%
“…Intranasal DEX appeared to perform as well as or better than intranasal midazolam for this indication (faster onset of sedation in one trial, 41 no difference in rate of adequate sedation or need for rescue medications in another 35 ). A prospective open-label study demonstrated universally successful sedation for CT imaging in pediatric patients with intranasal DEX, 42 a small retrospective chart review found that DEX facilitated completion of imaging in 86% of adult patients, 21 and four patients in a small pediatric case series were successfully sedated for various imaging tests with intramuscular DEX.…”
Section: Sedation To Facilitate Radiologic Imagingmentioning
confidence: 95%
“…Study designs included 11 RCTs, 22,[32][33][34][35][36][37][38][39][40][41] 13 cohort studies and other nonrandomized studies, [19][20][21]23,[42][43][44][45][46][47][48][49][50] and 11 case series and case reports. 12,[51][52][53][54][55][56][57][58][59][60] Six of the included studies were conference abstracts.…”
Section: Study Characteristicsmentioning
confidence: 99%
“…Two RCTs, 35,41 four cohort studies and other nonrandomized studies, 21,42,44,45 and one case series 52 reported the use of DEX specifically for sedation to facilitate radiologic imaging, generally in children. As above, pooling of efficacy results was not feasible.…”
Section: Sedation To Facilitate Radiologic Imagingmentioning
Sedatives, anxiolytics, and analgesics are near-ubiquitous interventions during daily care in the emergency department (ED). The agents most commonly used to treat intubated patients include sedatives acting on the gamma-aminobutyric acid (GABA) receptor, such as benzodiazepines and propofol, as well as the opioid analgesic fentanyl. Benzodiazepines are highly deliriogenic 1 and may prolong duration of mechanical ventilation and length of stay. 2 Propofol can be associated with significant hypotension and with a life-threatening
“…Study designs included 11 RCTs, 22,32–41 13 cohort studies and other nonrandomized studies, 19–21,23,42–50 and 11 case series and case reports 12,51–60 . Six of the included studies were conference abstracts 20,21,40,47,50,56 .…”
Section: Resultsmentioning
confidence: 99%
“…Intranasal DEX appeared to perform as well as or better than intranasal midazolam for this indication (faster onset of sedation in one trial, 41 no difference in rate of adequate sedation or need for rescue medications in another 35 ). A prospective open-label study demonstrated universally successful sedation for CT imaging in pediatric patients with intranasal DEX, 42 a small retrospective chart review found that DEX facilitated completion of imaging in 86% of adult patients, 21 and four patients in a small pediatric case series were successfully sedated for various imaging tests with intramuscular DEX.…”
Section: Sedation To Facilitate Radiologic Imagingmentioning
confidence: 95%
“…Study designs included 11 RCTs, 22,[32][33][34][35][36][37][38][39][40][41] 13 cohort studies and other nonrandomized studies, [19][20][21]23,[42][43][44][45][46][47][48][49][50] and 11 case series and case reports. 12,[51][52][53][54][55][56][57][58][59][60] Six of the included studies were conference abstracts.…”
Section: Study Characteristicsmentioning
confidence: 99%
“…Two RCTs, 35,41 four cohort studies and other nonrandomized studies, 21,42,44,45 and one case series 52 reported the use of DEX specifically for sedation to facilitate radiologic imaging, generally in children. As above, pooling of efficacy results was not feasible.…”
Section: Sedation To Facilitate Radiologic Imagingmentioning
Sedatives, anxiolytics, and analgesics are near-ubiquitous interventions during daily care in the emergency department (ED). The agents most commonly used to treat intubated patients include sedatives acting on the gamma-aminobutyric acid (GABA) receptor, such as benzodiazepines and propofol, as well as the opioid analgesic fentanyl. Benzodiazepines are highly deliriogenic 1 and may prolong duration of mechanical ventilation and length of stay. 2 Propofol can be associated with significant hypotension and with a life-threatening
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