The number of patients complaining of shoulder pain is gradually increasing, and women with shoulder pain in particular tend to present with psychological disorders and poor sleep quality. Therefore, the purpose of this study was to investigate whether psychological disorder and poor sleep quality mediated the relationship between shoulder pain and shoulder disability in women. This is a descriptive survey study of 222 women from 3 community centers in Seoul and Gyeonggi-do regions in South Korea. Data about shoulder pain, shoulder disability, sleep quality, depression, anxiety, and stress were collected using structured questionnaires between May 10 and June 7, 2021, and were analyzed by serial mediation analysis. The direct effect of shoulder pain on shoulder disability was statistically significant. Serial mediation model showed that sleep quality and psychological disorders (depression, anxiety, and stress) were sequential mediators between shoulder pain and shoulder disability among women. The relationship between shoulder pain and shoulder disability among women was partially mediated by sleep quality and psychological disorders (depression, anxiety, and stress). The results emphasize the importance of sleep quality and psychological factors in shoulder disability and suggest the use of strategies to improve sleep quality and alleviate psychological factors when developing an intervention program to mitigate shoulder disability in women with shoulder pain.