Comparing the Efficacy of Commercially Available Insecticide and Dimeticone based Solutions on Head Lice, Pediculus capitis: in vitro Trials

Balcıoğlu, İbrahim; Karakuş, Mehmet; Arserim, Süha Kenan; Limoncu, M. Emin; Töz, Seray; Baştemur, Serkan; Öncel, Koray; Özbel, Yusuf

doi:10.5152/tpd.2015.4652

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…The in-vitro effectiveness of the three commercial insecticides was tested as recommended by Balcioğlu et al (2015) and Kiesewetter et al (2013) using direct exposure of Rhipicephalus sanguineus ticks to the recommended (by the manufacturer) dose and concentration of the tested insecticides. Rhipicephalus sanguineus ticks were obtained from naturally parasitized dogs and maintained in the laboratory.…”

Section: Methodsmentioning

confidence: 99%

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

Aboelela¹,

Sobieh²,

Abouelhassan³

et al. 2022

Open Vet J

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Background: External parasites contribute to extensive harmful impacts on their hosts which is why control and eradication of external parasites have been included in all biosecurity plans of dog houses. Aim: To evaluate the in-vitro and in-vivo effectiveness of chemicals like Doramectin injectable and Fipronil 50 mg/ml drops and herbal mixes eco-friendly insecticides like phenylpyrazole–garlic–camphor mix spray for combating the external parasitism in dogs and their influence on the hematological, biochemical, and cortisol (CORT) profiles. Method: The in-vitro effectiveness of the insecticides was conducted by using a total of 216 developmental stage Rhipicephalus sanguineus (72 adults, 72 larvae, and 72 eggs) designed into three replicates of petri dishes (3 plates × 8 units × 3 stages/replicate); each replicate was exposed to 1 ml insecticide. The number of surviving ticks was recorded after 0, 2, 4, 8, 16, and 24 hours. Sixteen Rottweiler male dogs aged 1 year and 45.5 kg were divided into four groups. Three groups (G1, G2, and G3) were experimentally infested with R. sanguineus ticks 3–4 weeks post-dog arrival and kept under observation from zero-time of experimental infestation for 1–2 weeks. The three experimentally infested dog groups were treated with Doramectin injectable, Fipronil 50 mg/ml drops, and phenylpyrazole–garlic–camphor mix spray, respectively, and the fourth group was designed as a negative control. A total of 144 samples, including 48 ethylenediaminetetraacetic acid blood, 48 whole blood, and 48 sera samples, were collected. Results: The in-vitro efficacy revealed highly significant ( p < 0.01) 100% killing efficacy that was achieved after 8 hours in Doramectin and Fipronil 50 mg/ml and 24 hours in phenylpyrazole–garlic–camphor mix. The in-vivo trials revealed highly significant ( p < 0.01) improvements of red blood cells, hematocrit, mean corpuscular hemoglobin concentrations, platelets, total and differential leukocytic counts, erythrocyte sedimentation rates in the second hour, total protein, creatinine, alanine aminotransferase, urea, glucose, triglycerides, total cholesterol, and CORT levels in the 2-week (P 1 ) and 4-week posttreatment (P 2 ) samples in Dormectin, Fipronil 50 mg/ml, and phenylpyrazole–garlic–camphor mix-treated dogs with more pronounced recovery in phenylpyrazole–garlic–camphor mix spray-treated dogs. Conclusion: The insecticides were able to provide a high level of protection against experimental infestation with concern to the different modes of application. Phenylpyrazole–garlic–camphor mix spray (eco-friendly) achieved higher insecticidal act...

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Section: Methodsmentioning

confidence: 99%

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

Aboelela¹,

Sobieh²,

Abouelhassan³

et al. 2022

Open Vet J

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“…While the former showed 97.1% efficacy, the latter showed only 85.7% efficacy. 45 In another study, Balcioglu et al 46 compared the ex vivo efficacy of seven pediculicides (0.4% SMT, 0.6% PER, 0.3% pyrethrin, and 3% piperonyl butoxide), four formulations of DMT (with different or unknown concentrations of active ingredients), and a formulation based on mineral oils and foaming agents. Regardless of the instructions for use of each product, head lice were exposed for 20 minutes, and DMT was the most effective.…”

Section: Discussionmentioning

confidence: 99%

Pediculicide regulations and usage trends in Türkiye in 2015–2022

Sensoz,

Bilgener,

Mumcuoglu

et al. 2024

Int J Dermatology

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BackgroundOver the years, the increasing prevalence of head lice infestation has led to an increase in treatment‐related costs and the development of resistance to pediculicides. This study aimed to evaluate pediculicide sales over an 8‐year period (2015–2022), including the COVID‐19 pandemic.MethodsData on products registered in the Turkish Pharmaceutical Index Dataview, Intercontinental Medical Statistics (IMS) database, sold on prescription and approved by the Ministry of Health in Türkiye were formally requested from the research organization IQVIA for pharmacologically active pediculicides (PAP) such as permethrin, pyrethrin, and sumithrin. Data for physically active products containing dimethicone (DMT) were obtained from the relevant pharmaceutical companies. Sale revenues were determined based on sale prices in the aforementioned year.ResultsTotal sales of pediculicides decreased from 2,452,846 units in 2015 to 2,028,840 units in 2022. While PAP consumption decreased over the years, from 1,832,006 to 518,460 units, DMT consumption increased from 620,840 to 1,510,380 units, from 2015 to 2022. The total price of pediculicides for the consumer increased more than threefold in Turkish currency. In terms of USD, an almost similar amount of money was spent over the years, with the exception of 2022 when the expenditure almost halved mainly due to the high inflation rate in the country.ConclusionThe decrease in PAP and the increase in DMT indicate that local lice have developed resistance to the former. Further studies are needed to determine the possible development of resistance in the country.

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“…In addition, the failure of current chemical treatments to kill lice embryos in eggs, the environmental and food safety concerns posed by these treatments, and their potential toxicity to users necessitate the development of safe alternative treatment methods that can effectively kill adult lice and eggs via new modes of action [15,16], Other causes for the development of resistance to existing pediculicides include the persistence of pediculicide residue on hair, exposure of lice to sub-therapeutic concentrations, and inadequate concentration levels [5,6]. Numerous studies of the different types of head lice treatments have revealed that commercial pediculicides are ineffective in treating head lice infestations in students [12][13][14][17][18][19]. genetic mutations in the lice, which we plan to investigate in future studies.…”

Section: Discussionmentioning

confidence: 99%

Lindane Shampoo for Head Lice Treatment among Female Secondary School Students in Jeddah, Saudi Arabia: An Interventional Study

Abdullah¹,

Kaki²

2017

J Infect Dis Preve Med

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Comparing the Efficacy of Commercially Available Insecticide and Dimeticone based Solutions on Head Lice, Pediculus capitis: in vitro Trials

Abstract: Physically effective products can be repetitively used because they are non-toxic and resistance to them is not expected. To control the infestation at a public level, the use of these products needs to be encouraged with respect to their cost price.

Cited by 7 publications

References 16 publications

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

The in-vivo and in-vitro Effectiveness of Three Insecticides Types for Eradication of The Tick Rhipicephalus sanguineus in Dogs

Pediculicide regulations and usage trends in Türkiye in 2015–2022

Lindane Shampoo for Head Lice Treatment among Female Secondary School Students in Jeddah, Saudi Arabia: An Interventional Study

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