Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children

Hosseini, Habibollah; Shariatmadari, Maryam; Ayatollahi, Vida; Vaziribozorg, Sedighe; Meybodian, Mojtaba

doi:10.1007/s00405-021-07049-0

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…The result showed since administration of peritonsillar bupivacaine compared to acetaminophen had a better effect on managing postoperative pain and improving sedation and also since no complications were reported; The results of this study are consistent with our study and show that bupivacaine is effective in reducing pain after tonsillectomy surgery (24).…”

Section: Discussionsupporting

confidence: 90%

Evaluating the Effects of Peritonsillar Infiltration of Bupivacaine and Dexamethasone on Post-Tonsillectomy Pain Reduction in Kids

Moghadam¹,

Foji²,

Ghajari³

et al. 2023

Bulletin of Pharmaceutical Sciences. Assiut

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This study aimed to investigate the effect of percutaneous injection of bupivacaine and dexamethasone on pain relief after pediatric tonsillectomy. This clinical trial study was performed on 68 children undergoing tonsillectomy surgery. The intervention group was given topical dexamethasone and topical bupivacaine to reduce postoperative pain but oral paracetamol was administered at a dose of 15 mg/kg when pain score was > 4 in the control group patient. Postoperative pain was recorded by VAS score at 6, 12 and 24 hrs. In the experiment 51.5% of the subjects were male and 48.5% were female and mean age was 7.5 ± 2.99 years. Mean pain at 6 and 12 hrs after surgery was not significantly different between the intervention and control groups, but at 24 hrs after surgery the mean pain in the intervention group was 1.85 ± 0.85 and in the control group was 2.38 ± 1.18 which was statistically significant. There was no significant correlation between mean age, sex, weight, and duration of surgery with mean pain scores in the intervention group and control group at 6, 12 and 24 hrs after surgery.

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Section: Discussionsupporting

confidence: 90%

Evaluating the Effects of Peritonsillar Infiltration of Bupivacaine and Dexamethasone on Post-Tonsillectomy Pain Reduction in Kids

Moghadam¹,

Foji²,

Ghajari³

et al. 2023

Bulletin of Pharmaceutical Sciences. Assiut

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show abstract

“…However, use of acetaminophen alone compared to dexamethasone alone in tonsillectomy patients was not found to yield improved pain outcomes [12]. Recent studies evaluating the administration of peritonsillar bupivacaine compared to acetaminophen showed promising results for managing post-operative pain [15,16]. Dexmedetomidine has been shown to increase the time to the first need for analgesic medications, as well as prevent emergence agitation and decrease the opioid requirements of patients with OSA undergoing tonsillectomy [9,[17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Perioperative Acetaminophen and Dexmedetomidine Eliminate Post-Operative Opioid Requirement following Pediatric Tonsillectomy

Rudikoff

Tieu

Banzali

et al. 2022

JCM

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Administration of post-operative opioids following pediatric tonsillectomy can elicit respiratory events in this patient population that often arise as central and obstructive sleep apnea. The primary objective of this study was to determine whether a perioperative combination of dexmedetomidine and acetaminophen could eliminate post-operative (in recovery and at home) opioid requirements. Following IRB approval and a waiver for informed consent, the medical records of 681 patients who underwent tonsillectomy between 1 January 2013 and 31 December 2018 were evaluated. Between 1 January 2013 and 31 December 2015, all patients received a fentanyl-sevoflurane-based anesthetic, without acetaminophen or dexmedetomidine, and received opioids in recovery and for discharge home. On 1 January 2016, an institution-wide practice change replaced this protocol with a multimodal perioperative regimen of acetaminophen (intravenous or enteral) and dexmedetomidine and eliminated post-operative opioids. This is the first time that the effect of an acetaminophen and dexmedetomidine combination on the perioperative and home opioid requirement has been reported. Primarily, we compared the need for rescue opioids in the post-anesthesia care period and after discharge. The multi-modal protocol eliminated the need for post-tonsillectomy opioid administration. Dexmedetomidine in combination with acetaminophen eliminated the need for post-operative opioids in the recovery period.

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The efficacy of peritonsillar injection of bupivacaine vs intravenous acetaminophen on post-tonsillectomy pain in children

Luo

Huang

2021

Eur Arch Otorhinolaryngol

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Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children

Cited by 6 publications

References 14 publications

Evaluating the Effects of Peritonsillar Infiltration of Bupivacaine and Dexamethasone on Post-Tonsillectomy Pain Reduction in Kids

Evaluating the Effects of Peritonsillar Infiltration of Bupivacaine and Dexamethasone on Post-Tonsillectomy Pain Reduction in Kids

Perioperative Acetaminophen and Dexmedetomidine Eliminate Post-Operative Opioid Requirement following Pediatric Tonsillectomy

The efficacy of peritonsillar injection of bupivacaine vs intravenous acetaminophen on post-tonsillectomy pain in children

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