2016
DOI: 10.1016/j.ijsu.2015.11.008
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Comparing the endothelialisation of extracellular matrix bioscaffolds with coated synthetic vascular graft materials

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Cited by 12 publications
(11 citation statements)
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“…This endothelial cell motility is a critical aspect of angiogenesis [64]. Finally, we found out a comparable average cell proliferation to previous studies for EC culture over biodegradable scaffolds [63,65]. Despite our progress, a deeper understanding of cell attachment under hemodynamic conditions could provide further clues of changes in cell orientation and morphology.…”
Section: Discussionsupporting
confidence: 69%
“…This endothelial cell motility is a critical aspect of angiogenesis [64]. Finally, we found out a comparable average cell proliferation to previous studies for EC culture over biodegradable scaffolds [63,65]. Despite our progress, a deeper understanding of cell attachment under hemodynamic conditions could provide further clues of changes in cell orientation and morphology.…”
Section: Discussionsupporting
confidence: 69%
“…Moreover, in vitro experiments with grafts made of synthetic materials currently in clinical use showed that ECs produced isolated clumps and appeared as small spheroids with single point contact 54 . Synthetic vascular grafts coated with either antibodies or integrin-binding peptides have been developed for increasing cell adhesion to the inner lumen directly from the circulating blood stream 12, 5557 .…”
Section: Discussionmentioning
confidence: 99%
“…Polymer 8g7 provides a superior substrate for attachment and proliferation of ECs where cells appeared homogenously distributed and exhibit the typical cobblestone monolayer morphology associated with high levels of attachment and enhanced cellular proliferation 54 . Moreover, decellularized tissue-engineered arteries can be stored and thus made readily available for patients similar to synthetic graft materials.…”
Section: Discussionmentioning
confidence: 99%
“…[91][92][93] The HUVECs cultured on decellularized SIS demonstrated higher proliferation and appeared more evenly spread with a cobblestone morphology, when compared with the ePTFE and Dacron alternatives. 44 Although these characteristics are indicative of better endothelialization, an important mechanism in preventing platelet adhesion, 17 both native and decellularized SIS grafts are prone to thrombosis. 91,94 Endothelialization of the lumen and a variety of surface treatments, including the immobilization of heparin and growth factors, have been employed to prevent thrombosis and improve the patency of SIS grafts.…”
Section: Two-dimensional Tissuementioning
confidence: 99%
“…38,39 When utilized in tissue engineering scaffolds, ECM encourages constructive remodeling and favorable clinical outcomes. 40,41 Specifically in vascular applications, collagen, 42,43 fibrin, 44 fibronectin, 45 laminin, 46,47 chondroitin sulfate, 48 and vascular endothelial growth factor (VEGF) 49 have been shown to encourage endothelialization. However, ECM components can also lead to platelet activation and thrombosis, [50][51][52] so it is important to consider the individual components, as well as the overall composition of the ECM.…”
Section: Introductionmentioning
confidence: 99%