Comparing the fatty acid levels of preterm and term breast milk in Turkish women

Aydın, İbrahim; TURAN, Özden; AYDIN, Fevzi Nuri; KOÇ, Esin; HİRFANOĞLU, İbrahim Murat; AKYOL, Mesut; ÖZTOSUN, Muzaffer; AKGÜL, Emin Özgür; DEMİRİN, Hilmi; KILIÇ, Selim; ERBİL, Mehmet Kemal; Özgürtaş, Taner

doi:10.3906/sag-1302-131

Cited by 10 publications

(12 citation statements)

References 75 publications

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“…To explain these results, it must be remembered that AA is a key component of cell membranes, serves as a precursor to prostaglandin formation, and is clearly involved in the signalling systems of the brain [ 15 ]. Whilst it is acknowledged that maternal milk is the ideal milk and generally contains a higher concentration of AA than formula milk [ 8 , 28 , 29 ], the amount of AA needed by preterm infants to maintain ideal brain development is not clear, and more studies and further discussion are required. To clarify the results of this study, we reiterate that the two formula groups were randomly assigned, then observed and followed closely during the first two years of life.…”

Section: Discussionmentioning

confidence: 99%

Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial

Alshweki

Pérez-Muñuzuri

Bana

et al. 2015

Nutr J

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Background & aimsNutritional supplementation with polyunsaturated fatty acids is important in preterm infants neurodevelopment, but it is not known if the omega-6/omega-3 ratio affects this process. This study was designed to determine the effects of a balanced contribution of arachidonic acid in very preterm newborns fed with formula milk.MethodsThis was a randomized trial, in which newborns <1500 g and/or <32 weeks gestational age were assigned to one of two groups, based on the milk formula they would receive during the first year of life. Initially, 60 newborns entered the study, but ultimately, group A was composed of 24 newborns, who were given formula milk with an ω-6/ω-3 ratio of 2/1, and Group B was composed of 21 newborns, given formula milk with an ω-6/ω-3 ratio of 1/1. The infants were followed up for two years: growth, visual-evoked potentials, brainstem auditory-evoked potentials, and plasma fatty acids were periodically measured, and psychomotor development was assessed using the Brunet Lézine scale at 24 months corrected age. A control group, for comparison of Brunet Lézine score, was made up of 25 newborns from the SEN1500 project, who were fed exclusively with breast milk.ResultsAt 12 months, arachidonic acid values were significantly higher in group A than in group B (6.95 ± 1.55 % vs. 4.55 ± 0.78 %), as were polyunsaturated fatty acids (41.02 ± 2.09 % vs. 38.08 ± 2.32 %) achieved a higher average. Group A achieved a higher average Brunet Lézine score at 24 months than group B (99.9 ± 9 vs. 90.8 ± 11, p =0.028). The Brunet Lézine results from group A were compared with the control group results, with very similar scores registered between the two groups (99.9 ± 9 vs. 100.5 ± 7). There were no significant differences in growth or evoked potentials between the two formula groups.ConclusionsVery preterm infants who received formula with an ω-6/ω-3 ratio of 2/1 had higher blood levels of essential fatty acids during the first year of life, and better psychomotor development, compared with very preterm newborns who consumed formula with an ω-6/ω-3 of 1/1. Therefore, formula milk with an arachidonic acid quantity double that of docosahexaenoic acid should be considered for feeding very preterm infants.Trial registrationClinicalTrials.gov Identifier NCT02503020.

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Section: Discussionmentioning

confidence: 99%

Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial

Alshweki

Pérez-Muñuzuri

Bana

et al. 2015

Nutr J

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“…30 In a study on Turkish women, Aydın et al showed higher level of SFA in total FAs of breast milk (46.57% at 7 days, 51.56% at 28 days of lactation) than predicted in the control group of current study (44.84±3.93% in colostrum and 44.42±4.72% at 15 days of lactation). 31 Omega-3 supplementation further reduced the values. The fluctuations between the fatty acid levels in different countries might arise from the cultural habits, regional and seasonal differences in nutritional behaviours.…”

Section: Discussionmentioning

confidence: 91%

The effects of maternal omega-3 fatty acid supplementation on breast milk fatty acid composition

Ay¹,

Büyükuslu²,

Batirel³

et al. 2018

actapharm

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Breast milk is the first source of omega-3 fatty acids (FA) for infants. We hypothesized that maternal omega-3 FAs supplementation affects the FA composition of breast milk. Thirtysix women received 950 mg omega-3 polyunsaturated (PUFA) supplementation per day for 9 months from 22-24 weeks of pregnancy until the 6 months of lactation and 26 women were enrolled as controls. Demographic data and nutritional status were taken by a questionnaire. Breast milk samples were collected at just after birth and 6 months of lactation. Fatty acids were analyzed by gas chromatography mass spectrometry (GC-MS). Data was assessed using SPSS 22.0 software. The supplementation increased the level of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) while decreased the level of saturated fatty acids (SFA) in breast milk. The ratio of omega-6/omega-3 FAs was also decreased in the supplemented mothers' milk. In conclusion the maternal supplementation of omega-3 FAs improved the DHA and EPA levels.

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“…Mothers of infants appropriate for gestational age had markedly lower levels of total monounsaturated fatty acids, and higher levels of total and n −6 polyunsaturated fatty acids in their breast milk, compared to the milk from mothers of preterm infants small for gestational age . It was confirmed that term and preterm milk have different compositions of fatty acids . In a group comparison, the levels of some fatty acids (C14:0, C16:0, C18:1 and C20:5) increased significantly in the preterm group, whereas levels of myristoleic acid (C14:1) and eicosanoic acid (C20:0) increased significantly in the term group.…”

mentioning

confidence: 72%

Redox properties of transitional milk from mothers of preterm infants

Minić

Jesic

Đurović

et al. 2017

J Paediatrics Child Health

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Comparing the fatty acid levels of preterm and term breast milk in Turkish women

Cited by 10 publications

References 75 publications

Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial

Effects of different arachidonic acid supplementation on psychomotor development in very preterm infants; a randomized controlled trial

The effects of maternal omega-3 fatty acid supplementation on breast milk fatty acid composition

Redox properties of transitional milk from mothers of preterm infants

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