Comparing the Human and Sea Urchin Genomes

Cameron, R. Andrew

doi:10.1002/9780470015902.a0020745

Cited by 1 publication

(1 citation statement)

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“…The result of this cycle is two daughter cells with chromosomes that are identical to the mother cell. 17 Vinca alkaloids and taxanes are used in the treatment of cancer. Vinca alkaloids include vincristine, vinblastine, and vinorelbine are agents that inhibit microtubule formation.…”

Section: Antimitotic Drugsmentioning

confidence: 99%

Antimitotic Activity ofSamanea samanLeaf Extract in the In Vitro Development ofTripneustes gratillaEmbryo

Lam,

Casimpan,

Batoy

et al. 2023

Preprint

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INTRODUCTION: Commercially available anticancer drugs are expensive and may have side effects. This led the researchers to look into alternative plant sources. One of these is acacia or S. saman. OBJECTIVE: To determine whether S. saman leaf extract possesses antimitotic activity on T. gratilla embryos using vincristine sulfate as positive control. METHODOLOGY: S. saman leaves were extracted using hexane, CCl4, CHCl3, and water. T. gratilla embryos were fertilized in vitro. The fractions, vincristine sulfate, and DMSO in filtered sea water were added with the fertilized embryos in petri dishes. Samples were taken at 15 minutes after fertilization and every 30 minutes thereafter until the negative control reached a 32-cell stage. Fifty cells and their mean cell stage was evaluated per treatment. One-way ANOVA and Tukey tests were performed. RESULTS: Significant differences were seen starting at 75 minutes post fertilization up until the 165th minute using One-way ANOVA. The Tukey test showed that all aqueous and CCl4 as well as hexane (200, 400, 800 ppm) extracts had no significant difference compared to vincristine sulfate; while all CHCl3, hexane (100 ppm), and CCl4 (100 ppm) extracts showed a significant difference compared to vincristine. CONCLUSION: The aqueous, hexane, and carbon tetrachloride extracts possess potential antimitotic activity on T. gratilla embryos. Thus, it is a potential alternative to vincristine sulfate as an antimitotic agent.

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Section: Antimitotic Drugsmentioning

confidence: 99%