Comparing the performance of electrospun and cast nanocomposite film of polyamide-6 reinforced with multi-wall carbon nanotubes

Ghane, Nazanin; Mazinani, Saeedeh; Gharehaghaji, Ali Akbar

doi:10.1177/8756087918794229

Cited by 5 publications

(3 citation statements)

References 59 publications

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“…This precipitate underwent a thorough washing process with ethanol and DI water, carried out thrice to eliminate any unreacted reagents. Subsequently, the resultant NPs were dried in a vacuum oven (Drying oven VD 23, BINDER GmbH, Germany) at room temperature [41][42][43][44] . To eliminate CTAB, the prepared NPs were dispersed in ethanol containing NH 4 NO 3 for 6 h. The procedure of ion exchange was repeated 3 times.…”

Section: Preparation Of Silica-coated Mnpsmentioning

confidence: 99%

Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery

Ghane,

Khalili,

Khorasani

et al. 2024

Sci Rep

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The current study developed an innovative design for the production of smart multifunctional core-double shell superparamagnetic nanoparticles (NPs) with a focus on the development of a pH-responsive drug delivery system tailored for the controlled release of Phenytoin, accompanied by real-time monitoring capabilities. In this regard, the ultra-small superparamagnetic iron oxide@silica NPs (IO@Si MNPs) were synthesized and then coated with a layer of gelatin containing Phenytoin as an antiepileptic drug. The precise saturation magnetization value for the resultant NPs was established at 26 emu g-1. The polymeric shell showed a pH-sensitive behavior with the capacity to regulate the release of encapsulated drug under neutral pH conditions, simultaneously, releasing more amount of the drug in a simulated tumorous-epileptic acidic condition. The NPs showed an average size of 41.04 nm, which is in the desired size range facilitating entry through the blood–brain barrier. The values of drug loading and encapsulation efficiency were determined to be 2.01 and 10.05%, respectively. Moreover, kinetic studies revealed a Fickian diffusion process of Phenytoin release, and diffusional exponent values based on the Korsmeyer-Peppas equation were achieved at pH 7.4 and pH 6.3. The synthesized NPs did not show any cytotoxicity. Consequently, this new design offers a faster release of PHT at the site of a tumor in response to a change in pH, which is essential to prevent epileptic attacks.

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Section: Preparation Of Silica-coated Mnpsmentioning

confidence: 99%

Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery

Ghane,

Khalili,

Khorasani

et al. 2024

Sci Rep

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show abstract

“…These structures have shown the capability in bridging the gap site of injury area, simulating the structure of the neural ECM, forming various nanofibrous architectures (e.g., three‐dimensional or core‐shell), and guiding the neuronal outgrowth. Furthermore, they present a high surface area for better cell adhesion, combining with a wide range of natural or synthetic materials, biomolecules, cells, drugs, ECM compounds to overcome the body's inherent limitations of repair and recovery 21‐31 . The electrospinning technique is widely used to fabricate these structures.…”

Section: Introductionmentioning

confidence: 99%

Regeneration of the peripheral nerve via multifunctional electrospun scaffolds

Ghane

Khalili

Khorasani

et al. 2020

J Biomedical Materials Res

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Over the last two decades, electrospun scaffolds have proved to be advantageous in the field of nerve tissue regeneration by connecting the cavity among the proximal and distal nerve stumps growth cones and leading to functional recovery after injury. Multifunctional nanofibrous structure of these scaffolds provides enormous potential by combining the advantages of nano‐scale topography, and biological science. In these structures, selecting the appropriate materials, designing an optimized structure, modifying the surface to enhance biological functions and neurotrophic factors loading, and native cell‐like stem cells should be considered as the essential factors. In this systematic review paper, the fabrication methods for the preparation of aligned nanofibrous scaffolds in yarn or conduit architecture are reviewed. Subsequently, the utilized polymeric materials, including natural, synthetic and blend are presented. Finally, their surface modification techniques, as well as, the recent advances and outcomes of the scaffolds, both in vitro and in vivo, are reviewed and discussed.

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“…Recently, it is well accepted that PA6 based nanocomposites with excellent mechanical and thermal properties can be fabricated by introducing nano-carbon materials such as carbon nanotubes [30][31][32][33] and graphene. [34][35][36][37] Graphene is a two-dimensional material consisting of a single layer of carbon atoms arranged in a honeycomb structure, 38,39 endowing its' high mechanical, conductive and thermal conductivity.…”

mentioning

confidence: 99%

A facile strategy to improve the mechanical and thermal conductivity of PA6 nanocomposites by introducing graphene oxide/sodium benzoate compounding nucleator

Huang

Zhang

et al. 2021

J of Applied Polymer Sci

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In this study, a new and facile route has been developed to prepare graphene oxide (GO)/sodium benzoate (Sb) compounding nucleator (GO-Sb) reinforced polyamide 6 (PA6) nanocomposites. The effects and mechanism of adding GO/Sb compounding nucleator on the morphology and properties of PA6 nanocomposites were systematically investigated. The experimental resultsshowed that there are electrostatic interaction and π-π conjugation between GO and Sb, which make the GO-Sb compounding nucleator homogenously dispersed in matrix and gain good interfacial adhesion. XRD and DSC analysis revealed that incorporation of Sb improved the formation of γ-crystal. In addition, GO-Sb significantly enhanced the crystallization temperature of PA6 nanocomposites due to "the heterogeneous nucleating effects". The tensile results showed that the tensile strength and elastic modulus of the nanocomposites can be obviously improved by incorporation of GO-Sb compounding nucleator at low contents. The tensile strength and impact strength of the PA6-GO-Sb (100/0.05/0.25) nanocomposite were enhanced by 69.9% and 157.1%, respectively compared with pure PA6. Compared with pure PA6, the thermal conductivity of PA6-GO-Sb (100/0.05/0.25) nanocomposite increased by 258.8%. This simple and effective approach is believed to offer possibilities for broadening the graphene applications with the development of PA6-graphene nanocomposites.

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Comparing the performance of electrospun and cast nanocomposite film of polyamide-6 reinforced with multi-wall carbon nanotubes

Cited by 5 publications

References 59 publications

Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery

Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery

Regeneration of the peripheral nerve via multifunctional electrospun scaffolds

A facile strategy to improve the mechanical and thermal conductivity of PA6 nanocomposites by introducing graphene oxide/sodium benzoate compounding nucleator

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