Comparing the urinary pancreolauryl ratio and faecal elastase-1 as indicators of pancreatic insufficiency in clinical practice

A Rapid, Endoscopic Exocrine Pancreatic Function Test and the Lundh Test: A Comparative Study

“…In a study by Elphick and Kapur [20] , concentration of FE-1, correlated significantly with the clinical response to supplementation with pancreatic enzymes, suggesting ability of the test to predict EPI. We have previously found FE-1 concentrations to be a sensitive test for exocrine pancreatic function when the patients have prominent imaging findings suggestive of chronic pancreatitis [19] .…”

Partial Pancreatic Resection for Pancreatic Malignancy Is Associated with Sustained Pancreatic Exocrine Failure and Reduced Quality of Life: A Prospective Study

“…Faecal elastase-1 (FE-1), although an indirect test, is becoming more commonly used clinically to test for PEI. FE-1 has the advantages of ease of use and is relatively sensitive and specific [22]. It is clearly not as robust as direct measures as it only measures enzyme secretion, whereas fat absorption also requires normal luminal pH and mixing of enzymes and food, both of which may be disturbed by surgery; additionally, postoperative diarrhoea for other reasons (e.g.…”

Determinants of exocrine pancreatic function as measured by fecal elastase-1 concentrations (FEC) in patients with diabetes mellitus

“…It proofed to be sensitive in moderate and severe pancreatic insufficiency and it correlated with pancreatic duct changes in ERCP images [8,9]. Despite some critical comments [10,11] it has become a standard test for indirect measurement of exocrine function during the last years for its clinical usefulness [12,13]. Utilising this non-invasive test, it became possible to screen larger patient groups and several studies used it to investigate larger populations of both, patients with type-1 and type-2 diabetes mellitus.…”