Comparing Therapeutic Efficacy between Ivermectin, Selamectin, and Moxidectin in Canaries during Natural Infection with <i>Dermanyssus gallinae</i>

Todisco, Gianluca; Paoletti, Barbara; Giammarino, A.; Manera, Maurizio; Sparagano, Olivier; Iorio, Raffaella; Giannella, Benedetta; Robbe, Domenico

doi:10.1196/annals.1428.003

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…For example, it was found that the intra-abdominal injection of birds with ivermectin at 0.6 mg/kg was insufficient to control D. gallinae and efficacious concentrations were from 1.8 to 5.4 mg/kg [30, 31]. In addition, after the initial treatment, ivermectin and selamectin were most efficacious against D. gallinae on Day 16, and moxidectin was most effective in control of mites on Day 24 [32]. Compared with intraperitoneal injection or subcutaneous administration, oral administration is more convenient to birds (particularly for a large number of birds on poultry farms).…”

Section: Introductionmentioning

confidence: 99%

Acaricidal efficacy of orally administered macrocyclic lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood-meal digestion

Wang

Zhang

et al. 2019

Parasites Vectors

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Background The poultry red mite (PRM), Dermanyssus gallinae , is one of the most economically deleterious threats to laying-hen industry worldwide. Macrocyclic lactones (MLs) have been widely used in control of mites in mammals, but the effects of MLs on PRMs are not well studied. The main objective of the present study was to systematically evaluate the effects of three MLs, i.e. eprinomectin (EPR), moxidectin (MOX) or ivermectin (IVM), on PRMs fed on chicks following oral administration. Methods Chicks in treatment groups were orally administrated with EPR, MOX or IVM at a dose of 5.0 mg/kg bodyweight. Chicks in the control group received the carrier solvent without drug. Chicks in each cage were then infested with 200 starved adult D. gallinae . After infestation and feeding for 12 h, engorged mites were collected to evaluate the acaricidal efficacy of the MLs, and its impacts on the reproduction and blood-meal digestion of D. gallinae . Results MOX, IVM and EPR demonstrated higher acaricidal efficacies post-treatment compared with the control, i.e. 45.60% for MOX, 71.32% for IVM and 100% for EPR on Day 10. MLs did not have significant effects on the blood-meal ingestion of PRMs, but significantly slowed down blood digestion ( P < 0.0001). The oviposition rate, egg hatching rate and fecundity of PRMs in treatment groups were remarkably reduced. Among the three MLs, EPR exhibited the highest performance against PRMs, with an oviposition rate of 1.04%, fecundity of 0.33 eggs per mite and a zero egg hatching rate in EPR treated groups. Conclusions EPR, MOX or IVM administrated orally to chicks increased the mortality of D. gallinae , significantly slowed down their blood-meal digestion and significantly reduced their reproductive capability which included the oviposition rate, fecundity and egg hatching rate. The present study highlights the potential of MLs in the control of PRMs.

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Section: Introductionmentioning

confidence: 99%

Acaricidal efficacy of orally administered macrocyclic lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood-meal digestion

Wang

Zhang

et al. 2019

Parasites Vectors

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“…This compoundwhen administered in waterwas effective in removing Ascaris galli, Heterakis gallinarum and Capillaria spp. in poultry (Schepkins et al 1985;Sharma et al 1990;Todisco et al 2008;Khayatnouri et al 2011). It is a very lipophilic molecule, so residues remain for long periods in the treated animal tissues, especially those with a high fat content (Baynes et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Residue depletion of ivermectin in broiler poultry

Mestorino

Buldain

Buchamer

et al. 2017

Food Additives & Contaminants: Part A

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Helminth infections are widespread in the poultry industry. There is evidence of extra-label use of some drugs, such as ivermectin (IVM), in broiler poultry. Pharmacokinetic and residual studies of IVM in poultry, however, are rather scarce. Our aim was to determine time restrictions for broiler chickens fed with balanced feed mixed with IVM for 21 days, and thus achieve acceptable residual levels for consumption as established by the European Union. Sixty 1-day-old chicks were fed with food supplemented with IVM at 5 mg kg feed for 21 days. Groups of six treated animals were sacrificed at 0, 1, 2, 4, 8, 10, 15, 20 and 28 days after treatment. Liver, skin/fat, kidney and muscle samples were obtained. IVM were determined by liquid chromatography with fluorescence detection after automatic solid-phase extraction with SPE C cartridges. The highest concentrations were measured in the liver, which is logical given that IVM is a drug that undergoes extensive hepatic metabolism. The optimal withdrawal time for edible tissues of these animals to stay within the permitted residual levels were: 12 days for liver, 8 days for skin/fat, 0 days for muscle and 10 days for kidney.

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“…IVM is reported to be effective against nematode infections in poultry, but it is not approved for use in avian species. IVM administered in water was effective in removing Ascaris galli, Heterakis gallinarum, and Capillaria in poultry. − The available data describing the pharmacokinetic behavior of IVM in avian species is scarce. In some countries, until recently there were some oral formulations to control internal and external parasites in pet or game birds and fighting cocks, but most of them are no longer on the market.…”

Section: Introductionmentioning

confidence: 99%

Ivermectin Pharmacokinetics, Metabolism, and Tissue/Egg Residue Profiles in Laying Hens

Moreno

Domínguez

Farías

et al. 2015

J. Agric. Food Chem.

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The goals were to determine the ivermectin (IVM) plasma pharmacokinetics, tissue and egg residue profiles, and in vitro metabolism in laying hens. Experiments conducted were (1) 8 hens were intravenously treated with IVM and blood samples taken; (2) 88 hens were treated with IVM administered daily in water (5 days) (40 were kept and their daily eggs collected; 48 were sacrificed in groups (n = 8) at different times and tissue samples taken and analyzed); (3) IVM biotransformation was studied in liver microsomes. Pharmacokinetic parameters were AUC = 85.1 ng·day/mL, Vdss = 4.43 L/kg, and T1/2el = 1.73 days. Low IVM tissue residues were quantified with the highest measured in liver and skin+fat. IVM residues were not found in egg white, but significant amounts were quantified in yolk. Residues measured in eggs were greater than some MRL values, suggesting that a withdrawal period would be necessary for eggs after IVM use in laying hens.

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Comparing Therapeutic Efficacy between Ivermectin, Selamectin, and Moxidectin in Canaries during Natural Infection with Dermanyssus gallinae

Cited by 7 publications

References 5 publications

Acaricidal efficacy of orally administered macrocyclic lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood-meal digestion

Acaricidal efficacy of orally administered macrocyclic lactones against poultry red mites (Dermanyssus gallinae) on chicks and their impacts on mite reproduction and blood-meal digestion

Residue depletion of ivermectin in broiler poultry

Ivermectin Pharmacokinetics, Metabolism, and Tissue/Egg Residue Profiles in Laying Hens

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