The differential satire effects across domestic and foreign audiences are largely unknown; yet, this is of growing relevance as political satire increasingly reaches international audiences. A two-country experiment was conducted in which satirical stimuli from the Netherlands with either a one-sided (only targeting the United States) or two-sided humorous message (targeting both the U.S. and the Netherlands) was presented to a domestic (in-group) or foreign (out-group) audience. Specifically, this study examines political satire’s differential emotional and attitudinal impact on audiences located in the country-of-production (Netherlands) or abroad (U.S.). Results show that satire sidedness uniformly influenced hedonic enjoyment: compared to two-sided satire, one-sided satire elicited negative emotions and decreased positive emotions for both the in-group (Dutch) and the out-group (U.S.) audience. Yet, satire differentially affected patriotic attitudes. This effect was moderated by country and age: younger U.S. citizens became less patriotic after exposure to the one-sided satire that targeted their country and decreased their positive emotions; older U.S. citizens, in contrast, became more patriotic after exposure to this one-sided satire that particularly increased their negative emotions. The Dutch audience’s level of patriotism remained stable irrespective of satire sidedness. Altogether, this study demonstrates how humor type, country-of-reception, and age matter for satire effects.