Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression

Cagnin, Stefano; Knedlík, Tomáš; Vianello, Caterina; Rebelo, Ana Paula Magalhães; Mario, Agnese De; Giacomello, Marta

doi:10.3390/biomedicines11020596

Cited by 4 publications

(2 citation statements)

References 84 publications

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“…. On the contrary, symptoms of NB vary with site of presentation and include fever, emesis, fatigue, and abdominal masses that often manifest with constipation and abdominal distention that may be painful (23). Fever is a common symptom and is present in 26.0% of pediatric patients with NB, and NB is commonly diagnosed as cancer in infancy, with the median age at diagnosis being approximately 19 months (24,25).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical and imaging features for differentiating rhabdomyosarcoma from neuroblastoma in pediatric soft tissue

Sheng,

Li,

et al. 2024

Front. Oncol.

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BackgroundIn this study, we developed a nomogram predictive model based on clinical, CT, and MRI parameters to differentiate soft tissue rhabdomyosarcoma (RMS) from neuroblastoma (NB) in children preoperatively.Materials and methodsA total of 103 children with RMS (n=37) and NB (n=66) were enrolled in the study from December 2012 to July 2023. The clinical and imaging data (assessed by two experienced radiologists) were analyzed using univariate analysis, and significant factors were further analyzed by multivariable logistic regression using the forward LR method to develop the clinical model, radiological model, and integrated nomogram model, respectively. The diagnostic performances, goodness of fit, and clinical utility of the integrated nomogram model were assessed using the area under the curve (AUC) of the receiver operator characteristics curve (ROC) with a 95% confidence interval (95% CI), calibration curve, and decision curve analysis (DCA) curves, respectively. Diagnostic efficacy between the model and radiologists’ interpretations was examined.ResultsThe median age at diagnosis in the RMS group was significantly older than the NB group (36.0 months vs. 14.5 months; P=0.003); the fever rates in RMS patients were significantly lower than in patients with NB (0.0% vs.16.7%; P=0.022), and the incidence of palpable mass was higher in patients with RMS compared with the NB patients (89.2% vs. 34.8%; P<0.001). Compare NB on image features: RMS occurred more frequently in the head and neck and displayed homogeneous density on non-enhanced CT than NB (48.6% vs. 9.1%; 35.3% vs. 13.8%, respectively; all P<0.05), and the occurrence of characteristics such as calcification, encasing vessels, and intraspinal tumor extension was significantly less frequent in RMS children compared to children with NB (18.9% vs. 84.8%; 13.5% vs. 34.8%; 2.7% vs. 50.0%, respectively; all P <0.05). Two, three, and four features were identified as independent parameters by multivariate logistic regression analysis to develop the clinical, radiological, and integrated nomogram models, respectively. The AUC value (0.962), calibration curve, and DCA showed that the integrated nomogram model may provide better diagnostic performance, good agreement, and greater clinical net benefits than the clinical model, radiological model, and radiologists’ subjective diagnosis.ConclusionThe clinical and imaging features-based nomogram has potential for helping radiologists distinguish between pediatric soft tissue RMS and NB patients preoperatively, and reduce unnecessary interventions.

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Section: Discussionmentioning

confidence: 99%

Evaluation of clinical and imaging features for differentiating rhabdomyosarcoma from neuroblastoma in pediatric soft tissue

Sheng,

Li,

et al. 2024

Front. Oncol.

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“…The coordinated stability of MAMs’ structure and function is the material basis for maintaining normal cell physiological function ( 6 , 7 ). Recent studies have shown that abnormal MAMs’ structure and function are closely related to the occurrence and development of many clinical diseases, such as metabolic syndrome ( 8 ), cancer ( 9 ), and neurodegenerative diseases ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Mfn2 regulates mitochondria-associated ER membranes to affect PCOS oocyte development

Liao,

Zhu,

Qiu

et al. 2023

Endocrine Connections

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This study aimed to investigate the role of mitochondrial-related protein Mfn2 in polycystic ovary syndrome (PCOS) and its impact on oocyte development. The pathological features of PCOS model mice were confirmed by hematoxylin–eosin staining and immunohistochemistry. The expression of Mfn2 and mitochondrial-related proteins in PCOS oocytes and granulosa cells was detected by qRT-PCR and Western blot. Mitochondrial quantity was measured by Mito-Tracker staining, and the structure of mitochondria-associated ER membranes (MAMs) was observed by transmission electron microscopy. The results showed that Mfn2 was significantly downregulated in PCOS oocytes and granulosa cells, and its expression was inhibited in oocytes at different developmental stages. Moreover, the structure of MAMs was also disrupted. Downregulation of Mfn2 expression led to a reduction in mitochondrial quantity in oocytes and granulosa cells, as well as disruption of MAM structure, while overexpression of Mfn2 had the opposite effect. In conclusion, this study indicates that Mfn2 affects the development of PCOS oocytes by regulating MAMs and may be involved in maintaining the stability of MAM structure and function, thereby affecting mitochondrial quantity and function. These findings provide new insights into the pathogenesis and treatment of PCOS.

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Development and validation of a nomogram for predicting survival in intermediate- and high-risk neuroblastoma of the Children's Oncology Group risk stratification

Feng,

Kan,

Wang

et al. 2023

J Cancer Res Clin Oncol

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Comparison among Neuroblastoma Stages Suggests the Involvement of Mitochondria in Tumor Progression

Cited by 4 publications

References 84 publications

Evaluation of clinical and imaging features for differentiating rhabdomyosarcoma from neuroblastoma in pediatric soft tissue

Evaluation of clinical and imaging features for differentiating rhabdomyosarcoma from neuroblastoma in pediatric soft tissue

Mfn2 regulates mitochondria-associated ER membranes to affect PCOS oocyte development

Development and validation of a nomogram for predicting survival in intermediate- and high-risk neuroblastoma of the Children's Oncology Group risk stratification

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