Comparison and Analysis of Polymer-Functionalized Carbon Nanotubes for Enhancement of the Quantitative Detection of Procalcitonin Levels in Human Plasma

Schuck, Ariadna; Kim, Hyo Eun; Kang, Minhee; Kim, Yong−Sang

doi:10.1007/s13206-023-00102-6

Cited by 8 publications

(3 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A combi-matrix consisting of TiO 2 aerogel and CHCA was used for the medical diagnosis of sepsis through analysis of the sepsis marker LPC-16. − From the previous research, LPC-16 concentration was found to be lower in the sera of patients with sepsis than in healthy controls . Furthermore, the confirmation of serum-originated biomarkers to LPC-16 was conducted by tandem mass analysis between serum extracted candidate and pure LPC-16 compound .…”

Section: Resultsmentioning

confidence: 99%

Combi-Matrix Based on TiO₂ Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry

Yun,

Song,

Kim

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

To apply semiconductor nanostructures as a solid matrix for laser desorption/ionization-mass spectrometry, the nanostructures should exhibit ionization activity through photocatalytic reactions and desorption enhancement through photothermal conversion. Herein, TiO 2 aerogels were synthesized using titanium(IV) butoxide as a precursor, and a controlled porous structure was obtained by adjusting the ethanol content and annealing temperatures. The photocatalytic activity of the TiO 2 aerogel was estimated using pseudofirst-order kinetics on methylene blue degradation reactions. To achieve further desorption/ionization properties, a combi-matrix was produced using the TiO 2 aerogel and a conventional organic matrix, αcyano-4-hydroxynnamic acid (CHCA). The enhanced ionization efficiency of the TiO 2 aerogel combi-matrix was demonstrated along with an improved signal-to-noise ratio from other solid matrix combi-matrix systems. Meanwhile, the distribution of CHCA crystals in TiO 2 aerogel with various annealing conditions was investigated by differential scanning calorimetry with the Gibbs−Thomson equation. The radius of CHCA crystals was minimized at 550 °C but increased steeply at heat treatment temperatures higher than 600 °C, implying a collapse in the pore structure of the TiO 2 aerogel. Furthermore, the activation energy for melting the CHCA nanocrystals was calculated using the Arrhenius equation. These results showed that CHCA nanocrystals in a combi-matrix with the TiO 2 aerogel after annealing at 550 °C could be most effectively melted with lower activation energy via the pore structure and the binary phased TiO 2 aerogel. Finally, the combi-matrix based on TiO 2 aerogel was applied for the analysis of the sera from sepsis patients (n = 40), systemic inflammatory response syndrome (SIRS) patients (n = 20), and healthy controls (n = 20), finding that the combi-matrix based on TiO 2 aerogel could be effectively used for the diagnosis of sepsis using lysophosphatidylcholine (LPC-16) as a biomarker.

show abstract

Section: Resultsmentioning

confidence: 99%

Combi-Matrix Based on TiO₂ Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry

Yun,

Song,

Kim

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

show abstract

“…Nanotechnology is a field of science that focuses on nanoscale materials with functional applications. 31–33 It has garnered considerable interest, particularly due to the unique features of nanostructured materials providing advantages in interfacial and surface chemistry, which are important for various applications. 34 The development of nanotechnology has contributed to advances in healthcare and medicine, holding ever greater promise.…”

Section: Nanotechnology For Ad Treatment and The Bbbmentioning

confidence: 99%

Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment

Boyetey,

Choi,

Lee

et al. 2024

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

“…These changes serve as valuable indicators that enable the detection and quantification of sepsis biomarkers. 58 Various advanced techniques, including differential pulse voltammetry (DPV) or fluorescence spectroscopy, 59 are employed to accurately measure these alterations and provide reliable detection results. Significantly, CNT-based biosensors have been successfully developed and optimized for the specific identification and measurement of several sepsis biomarkers, including procalcitonin and C-reactive protein.…”

Section: Nanodiagnostic Techniques For Early Detection Of Bacterial S...mentioning

confidence: 99%

Recent advances and prospects in nanomaterials for bacterial sepsis management

Zhou,

Liu,

et al. 2023

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Comparison and Analysis of Polymer-Functionalized Carbon Nanotubes for Enhancement of the Quantitative Detection of Procalcitonin Levels in Human Plasma

Cited by 8 publications

References 45 publications

Combi-Matrix Based on TiO₂ Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry

Combi-Matrix Based on TiO₂ Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry

Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment

Recent advances and prospects in nanomaterials for bacterial sepsis management

Contact Info

Product

Resources

About

Comparison and Analysis of Polymer-Functionalized Carbon Nanotubes for Enhancement of the Quantitative Detection of Procalcitonin Levels in Human Plasma

Cited by 8 publications

References 45 publications

Combi-Matrix Based on TiO2 Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry

Combi-Matrix Based on TiO2 Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry

Nanotechnology-based delivery of therapeutics through the intranasal pathway and the blood–brain barrier for Alzheimer's disease treatment

Recent advances and prospects in nanomaterials for bacterial sepsis management

Contact Info

Product

Resources

About

Combi-Matrix Based on TiO₂ Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry

Combi-Matrix Based on TiO₂ Aerogel for Diagnosis of Sepsis Using Laser Desorption and Ionization Mass Spectrometry