Comparison Between 2 Electronic Databases to Evaluate Potential Drug–Drug Interactions in Prescriptions of Surgical Patients

Sánchez-López, Virginia Aleyda; Hernandez-Cañaveral, Iván; Huerta-Olvera, Selene G.

doi:10.1097/mjt.0000000000000624

Cited by 1 publication

(2 citation statements)

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“…The mean day of hospital stay was 9.9 days (±10.1, range: 0-122). The mean number of distinct diagnoses at discharge was 4.5 (±3.1, range: [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. The mean number of medications used during hospitalization was 23.7 (±14.3, range: 1-101).…”

Section: Resultsmentioning

confidence: 99%

“…3,4 Also, the adverse interactions between chronic medications and medications related to surgeries, for instance, anesthetics, analgesics, antibiotics and contrast agents, jeopardize surgical outcomes for the aged patients. 5 For these reasons, it is necessary to review the perioperative medications for the elderly all along the care pathway to identify drugs that potentially imperil the safety of the patients.…”

Section: Introductionmentioning

confidence: 99%

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High-Risk Perioperative Medications in the Chinese Elderly Population

Wang

Ren

Tan

et al. 2021

CIA

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Background: Inappropriate perioperative medications among elderly patients increase the risk of adverse events and undermine surgical outcomes. This study aimed to assess the prevalence of high-risk medications in elderly surgical patients and verify the effectiveness of a new-developed high-risk perioperative medications (HRPOMs) list for the elderly. Methods: A cross-sectional, single-center study was conducted at Jinshan Hospital of Fudan University. A total of 810 elderly surgical patients were included in the study. The HRPOMs list was applied to patients' data to identify the HRPOMs including chronic medications and medications related to surgery. Results: A total of 2113 HRPOMs were identified in 810 patients who fulfilled the inclusion criteria. Of these, 1067 (50.5%) involved medications related to surgery, and 982 (46.5%) involved chronic medications. The prevalence of HRPOM exposure, which was defined as at least one HRPOM was 76.3%. Patients that were 70 years or older (adjusted odds ratio [AOR] =2.118, 95% confidence interval [CI], 1.420~3.159), hospitalized over two weeks (AOR =4.192, 95% CI, 1.493~11.771), with more than 2 distinct diagnoses (AOR =3.407, 95% CI, 2.224~5.220) and with 16 or more medications during hospitalization were more likely to be exposed to HRPOMs. Patients who underwent surgeries of Grade IV were at 1.73 increased odds of HRPOM exposure compared with those who received surgeries of Grade III or lower (P=0.071). Conclusion:HRPOMs are more common in patients of 70 years or older, with 3 or more distinct diagnoses, with 16 or more medications and hospitalized for 15 days or longer. Our study showed the validity of the HRPOMs list in the perioperative medication review for the elderly and may induce further research to reveal the impact of HRPOMs upon the surgical outcomes of the elderly.

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