Comparison between 201Tl-chloride and 99Tcm-sestamibi SPET brain imaging for differentiating intracranial lymphoma from non-malignant lesions in AIDS patients

Naddaf, Sleiman; Akisik, M. Fatih; Aziz, Mohamed; Omar, Walid; Hirschfeld, Azriel; Masdeu, Joseph C.; Donnenfeld, Hyman; Abdel‐Dayem, Hussein M.

doi:10.1097/00006231-199801000-00007

Cited by 30 publications

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“…More studies using only pathology and/or serology as the gold standard are needed to reach a definite conclusion. Other factors that have been reported in the literature to further increase the sensitivity and/or specificity of SPECT include delayed imaging, [45] 99Tcm-sestamibi as tracer instead of 201 TI, [15] larger lesion size, [46] and the addition of serum Toxoplasma IgG [47] and EBV PCR. [48] Giancola et al suggested that HAART may artificially increase 201 TI uptake in patients with toxoplasmosis, resulting in lower diagnostic accuracy in the post-HAART era.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of SPECT, PET, and MRS for primary central nervous system lymphoma in HIV patients

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of SPECT, PET, and MRS for primary central nervous system lymphoma in HIV patients

et al. 2017

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“…Other nuclear medicine techniques have been used to aid discrimination between toxoplasmosis and lymphoma including technetium-99m Sestamibi ( 99 Tc m MIBI) SPET, 31 and fluorine-18 fluorodeoxyglucose positron emission tomography ( 18 FDG PET). 32 SPET with 99 Tc m MIBI was compared with 201 Tl in a study of 17 HIV infected patients with focal CNS lesions (four had biopsy proved lymphoma).…”

Section: Discussionmentioning

confidence: 99%

“…For diagnosis of lymphoma both techniques had 100% sensitivity but a specificity and negative predictive value of 69% and 54% for 99 Tc m MIBI and 54% and 40% for 201 Tl. 31 The higher preferential uptake by the choroid plexus of 99 Tc m MIBI compared with 201 Tl means that in HIV infected patients it is more diYcult to evaluate focal CNS lesions which are paraventricular in location as may occur in cerebral lymphoma. 31 18 FDG PET which can measure regional metabolic activity accurately discriminates between toxoplasmosis and lymphoma (and other conditions including progressive multifocal leucoencephalopathy).…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging, thallium-201 SPET scanning, and laboratory analyses for discrimination of cerebral lymphoma and toxoplasmosis in AIDS.

Miller

Hall-Craggs²,

Costa³

et al. 1998

Sex Transm Infect

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Objectives:To compare the results of magnetic resonance imaging (MRI) and thallium-201 ( 201 Tl) SPET scanning with laboratory analyses including CSF DNA detection, brain biopsy, and necropsy in the discrimination of cerebral lymphoma and toxoplasmosis in patients with AIDS. Methods: A retrospective study of 32 patients infected with HIV who had focal CNS lesions on MRI as a result of either lymphoma or toxoplasmosis. Results: 18 patients had lymphoma, 12 had toxoplasmosis, and two had both. Toxoplasma IgG antibodies were detected in only seven patients-four with toxoplasmosis, two with lymphoma, and one with both diagnoses. Epstein-Barr virus DNA was detected in CSF of all six patients with lymphoma and none of two with toxoplasmosis. MRI showed multiple lesions in 23 patients, appearances did not discriminate between lymphoma and toxoplasmosis; nine patients had single lesions, of these eight had lymphoma (p=0.044, two tailed Fisher's exact test) 201 Tl SPET showed accumulation in 17 with lymphoma and six with toxoplasmosis (p = 0.034, two tailed Fisher's exact test). Of nine patients with single lesions on MRI and 201 Tl SPET with focal accumulation eight had lymphoma.201 Tl SPET uptake ratios of >2.9 were only seen with lymphoma. Conclusion: Knowledge of patients' toxoplasma serostatus does not aid discrimination between lymphoma and toxoplasmosis. Single lesions on MRI with focal accumulation of 201 Tl strongly suggest lymphoma. Multiple lesions on MRI with 201 Tl SPET uptake ratios >2.9 also suggest lymphoma; uptake ratios less than 2.1 do not aid discrimination. Detection of Epstein-Barr virus DNA in CSF is highly sensitive and specific for cerebral lymphoma. (Sex Transm Inf 1998;74:258-264)

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“…If performed within 5 days of symptom onset, it has been found capable to differentiate neoplastic from nonneoplastic intracerebral hematomas (Minutoli et al 2005 ). When compared to 201 Tl, it proved superior for differentiating intracranial lymphoma from nonmalignant lesions, exhibiting similar sensitivity but higher specifi city (Naddaf et al 1998 ).…”

Section: Recently Fotopoulos Et Al Studied By 99mmentioning

confidence: 98%

Single-Photon Emission Computed Tomography [Neuro-SPECT] Imaging of Brain Tumors

Alexiou

Tsiouris

Fotopoulos

2014

PET and SPECT in Neurology

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Primary brain tumors have an annual incidence rate of 7-19.1 cases per 100,000 population. Metastatic tumors to the brain are more common with more than 100,000 patients per year in the United States. Gliomas are the most common primary brain tumor. CT and MRI are necessary to characterize the tumor type, size, and extension. Nevertheless, in patients with brain lesions, it is not uncommon for CT and MRI to provide nonspecifi c information, even after contrast or gadolinium infusion. Imaging of intracranial space-occupying lesions by nuclear medicine techniques such as SPECT and PET have also been introduced as methods providing information about the metabolic status of various brain

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Comparison between 201Tl-chloride and 99Tcm-sestamibi SPET brain imaging for differentiating intracranial lymphoma from non-malignant lesions in AIDS patients

Cited by 30 publications

References 0 publications

Diagnostic accuracy of SPECT, PET, and MRS for primary central nervous system lymphoma in HIV patients

Diagnostic accuracy of SPECT, PET, and MRS for primary central nervous system lymphoma in HIV patients

Magnetic resonance imaging, thallium-201 SPET scanning, and laboratory analyses for discrimination of cerebral lymphoma and toxoplasmosis in AIDS.

Single-Photon Emission Computed Tomography [Neuro-SPECT] Imaging of Brain Tumors

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