Comparison between a guaiac and three immunochemical faecal occult blood tests in screening for colorectal cancer

Alternatives to colonoscopy for population-wide colorectal cancer screening

“…18,28,30,31 The PPV ranges from 5.2% to 12.8% at a cut-off value of 75 ng/mL. 12,13,[17][18][19][28][29][30][31][32] The NNScreen and NNScope ranges from 213 to 936 and 12,13,17,19,[28][29][30]32 These results are summarised in Table 2. For advanced adenoma, the sensitivity and specificity ranges from 33.9% to 41.3% and 91.4% to 97.3%, respectively.…”

“…13 Studies showed the detection rate for advanced adenoma using iFOBT to be at least double that of gFOBT. 12,29 In the study by Faivre et al, 32 iFOBT was 1.7 to 2.1 times more sensitive than gFOBT for CRC. 32 A study by Brenner and Tao 30 showed significantly higher PPV for iFOBTs than gFOBTs (7.3%-10.0% vs 4.5%).…”

“…12,29 In the study by Faivre et al, 32 iFOBT was 1.7 to 2.1 times more sensitive than gFOBT for CRC. 32 A study by Brenner and Tao 30 showed significantly higher PPV for iFOBTs than gFOBTs (7.3%-10.0% vs 4.5%). In two comparative studies, the NNScreen of iFOBT was about half that of gFOBT 29,32 ; iFOBT also had a 13.0% to 15.0% higher participation rate than gFOBT.…”

“…32 A study by Brenner and Tao 30 showed significantly higher PPV for iFOBTs than gFOBTs (7.3%-10.0% vs 4.5%). In two comparative studies, the NNScreen of iFOBT was about half that of gFOBT 29,32 ; iFOBT also had a 13.0% to 15.0% higher participation rate than gFOBT. 13,15,16,20,33 The iFOBT is more costly than its guaiacbased counterpart, 20 but modelling studies showed that it is more cost-effective.…”

Home-use faecal immunochemical testing: primary care diagnostic technology update

“…7 Numerous diagnostic accuracy studies support that laboratory-based quantitative FIT has higher sensitivity and specificity when screening colorectal cancer than gFOB, especially for detecting high-risk adenomas. Tip of top is snapped off and two drops are dropped into the dropping hole of the test cassette and result given in 5 minutes.…”