Comparison between airways response to an alpha‐adrenoceptor agonist and histamine in asthmatic and non‐asthmatic subjects.

Jl, Black; Salome, CM; Yan, Kwok; Shaw, John H.

doi:10.1111/j.1365-2125.1982.tb02012.x

Cited by 27 publications

(21 citation statements)

References 12 publications

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“…Those agonists contract isolated bronchial smooth muscle [7,8], enhance in vitro secretion of airways submucosal glands [25], and facilitate histamine release from sensitized human lung tissue [26]. These effects probably account for the development of bronchial obstruction ascribed to stimulation of α 1 -adrenoceptors in some asthmatic subjects [7,[27][28][29]. They are also consistent with reported beneficial effects of various α 1 -adrenoceptor antagonists in asthma [30][31][32].…”

Section: Discussionsupporting

confidence: 66%

Effects of pretreatment with inhaled methoxamine on bronchial responses to histamine in asthmatic subjects

Phan-Puibaraud¹,

Regnard²,

Monchi³

et al. 1995

Eur Respir J

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The underlying mechanisms of bronchial obstruction in asthma are complex. Both bronchospasm and bronchial oedema are thought to play pivotal roles in asthma, but their respective importance in a given asthmatic individual is unknown. To address this question, we assessed the effects of pretreatment with inhaled methoxamine, a potent alpha 1-adrenoceptor agonist, on bronchial response to inhaled histamine in 10 asthmatic subjects. The study was conducted according to a double-blind, cross-over, randomized and placebo-controlled design. In each subject, dose-response curves for the effects on forced expiratory volume in one second (FEV1) of serially doubling doses of inhaled histamine were obtained on three different days, 15 min after pretreatment with either methoxamine (10 mg) or duplicated placebo. Histamine, first dose 100 micrograms (543 nmol), was delivered by a breath-activated dosimeter every 5 min. FEV1 was measured in triplicate after each dose and the largest value was retained. There was no difference in baseline and prechallenge FEV1 after placebo and methoxamine. Mean coefficient of variation of decrease in FEV1 induced by histamine on the two placebo days was 6.7 +/- 2%. On average, the bronchial responses to histamine were not modified by pretreatment with methoxamine as compared to placebo (delta FEV1 = 0.83 +/- 0.14 l on methoxamine versus 0.85 +/- 0.11 l and 0.86 +/- 0.13 l on the two placebo days).(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionsupporting

confidence: 66%

Effects of pretreatment with inhaled methoxamine on bronchial responses to histamine in asthmatic subjects

Phan-Puibaraud¹,

Regnard²,

Monchi³

et al. 1995

Eur Respir J

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“…We have previously reported (Black et al, 1982) that methoxamine, an a-adrenoceptor agonist, induced bronchoconstriction in 10 asthmatic subjects. No such reaction occurred, however, in 10 subjects with no clinical history of asthma, although four of these exhibited bronchoconstriction in response to inhaled histamine.…”

Section: Introductionmentioning

confidence: 99%

The action of prazosin and propylene glycol on methoxamine‐induced bronchoconstriction in asthmatic subjects.

Black¹,

Salome²,

Yan³

et al. 1984

Brit J Clinical Pharma

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The effect of 1 mg inhaled prazosin on bronchoconstriction induced by methoxamine was investigated in seven asthmatic subjects. Prazosin caused significant inhibition of the methoxamine‐induced bronchoconstriction in six of the seven patients. These findings suggest that methoxamine produces bronchoconstriction in asthmatic subjects via stimulation of alpha‐adrenoceptors. In previous studies propylene glycol has been used as a vehicle for delivery of prazosin. This substance was found to cause significant inhibition of methoxamine effects and to shift the dose response curve to histamine to the right in four of seven patients.

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“…The dose selected (0.15 mg kg-1) was chosen because it had been shown to attenuate exerciseinduced asthma, a response in asthmatic airways thought in part to be due to post-exertional airway rewarming and rebound vasodilatation (Dinh Xuan et al, 1989). However, methoxamine may have a direct effect on airway calibre in asthma in causing bronchoconstriction (Snashall et al, 1978), although like others (Black et al, 1982;Snashall et al, 1978) we have failed to find any such effect in normal subjects.…”

Section: Discussionmentioning

confidence: 41%

The effect of respiratory manoeuvres and pharmacological agents on the pharmacokinetics of nedocromil sodium after inhalation.

Summers

Singh

Honeywell

et al. 1992

Brit J Clinical Pharma

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Comparison between airways response to an alpha‐adrenoceptor agonist and histamine in asthmatic and non‐asthmatic subjects.

Cited by 27 publications

References 12 publications

Effects of pretreatment with inhaled methoxamine on bronchial responses to histamine in asthmatic subjects

Effects of pretreatment with inhaled methoxamine on bronchial responses to histamine in asthmatic subjects

The action of prazosin and propylene glycol on methoxamine‐induced bronchoconstriction in asthmatic subjects.

The effect of respiratory manoeuvres and pharmacological agents on the pharmacokinetics of nedocromil sodium after inhalation.

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