Comparison between Antimicrobial Photodynamic Therapy and Injectable Platelet Rich Fibrin as an adjunct to Non-Surgical Periodontal Treatment (A Randomized Controlled Clinical Trial with Microbiological Assessment)

Abstract

Background:The aim of this study was to compare the efficacy of injectable form of PRF to antimicrobial photo dynamic therapy as an adjunctive treatment to non-surgical periodontal therapy in patients with stage III grade B periodontitis in terms of clinical improvement and antimicrobial ability.Subjects and Methods: 39 patients of each gender with age vary from 30 to 60 years diagnosed with stage III grade B periodontitis. The patients were divided randomly into three groups. (Group I) 13 patients treated by SRP (scaling and root planning) with application of i-PRF, (Group II) 13 patients treated by SRP with application of 940 nm diode laser and Indocyanine green (ICG), (Group III) treated by SRP alone as a control group. Clinical parameters such as GI (gingival index), PI (plaque index), CAL (clinical attachment level) and PD (probing depth) were recorded preoperatively and 3 months post operatively. Site-specific measure of bactericidal effect against Pg (Porphyromonas gingivalis) preoperative, 1 week postoperative and 1 month postoperative for all groups.Results: group I who receiving i-PRF resulted in a significant decrease in the percentage of Pg at the end of 1 month when compared to the other groups. Comparison of clinical parameters revealed significant differences in patients treated with aPDT in relation to GI, and CAL while i-PRF group , was better in PD at the end of the study period. Conclusion:i-PRF and aPDT may enhance the potential benefits of SRP in periodontitis patients and can be used as an adjunct to nonsurgical periodontal therapy.

Platelet-Rich Plasma (PRP) and Injectable Platelet-Rich Fibrin (i-PRF) in the Non-Surgical Treatment of Periodontitis—A Systematic Review

“…CAL and PPD were investigated in all i-PRF studies [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. Each showed reductions in pocket depth and improvements in CAL rates.…”

“…Shunmuga et al [ 51 ] conducted a study on patients diagnosed with type 2 diabetes, and concluded that i-PRF application toSRP in these patients provided similar benefits to saline application to SRP. Elarif et al [ 45 ] demonstrated that patients treated with SRP in conjunction with i-PRF exhibited greater gingival pocket reduction in comparison to the control group treated with SRP alone and to the group treated with SRP in conjunction with antimicrobial photodynamic therapy (aPDT). Furthermore, the same group treated with i-PRF exhibited a superior bactericidal effect against Porphyromonas gingivalis in comparison to the other groups.…”

Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Stage II or Stage III Periodontitis: A Randomized Controlled Trial with Microbiological Analysis

“…The ideal in bacterial infection is to take a baseline sample, then after one week, the 3rd sample after two weeks or one month according to the time needed for healing thatis why GCF samples were taken for bacterial load assessment at baseline, after 7 days from the last full mouth debridement, and 30 days after therapy [37][38] . The GCF fluid was collected by inserting perio-paper (Oraflow Inc., Smithtown, NY, USA) until resistance was felt into the pocket for 30s.…”