AimTo discuss the multi‐centre qualitative methodology as a unique design, articulate its guiding paradigm/theoretical perspectives, and highlight its methodological and methodical issues. A secondary objective is to generate further scholarly discourse regarding the multi‐centre approach within the broader qualitative research tradition.DesignMethodological discussion.FindingsRather than an emphasis on only experiences, the multi‐centre approach is presented as a unique design which also focuses on uncovering why a phenomenon or problem exists and perceptions regarding the phenomenon/problem. With its focus on capturing multiple subjective realities, the multi‐centre qualitative design is arguably underpinned by pragmatist constructivism which offers a robust framework for researching phenomenon in a way that is both theoretically informed and practically relevant. Methodologically, the multi‐centre qualitative research design emphasises a problem‐centred enquiry, collaborative approach and rigorous study protocols, systematic site selection, contextual immersion and sensitivity and methodical flexibility.ConclusionWith the rapidly evolving nursing and global health landscape, the multi‐centre design lends itself to exploring and capturing perceptions on a larger scale compared to single site studies. Careful planning, availability of adequate resources, rigorous protocols and quality assurance plans are critical to ensuring its success.Implications for Profession and Patient CareThe multi‐centre approach offers the possibility of undertaking the same study across multiple settings/locations which has the potential to improve representation and strengthen transferability.ImpactThis methodological discussion offers clarity regarding the use of the multi‐centre approach and offering strategies for its subsequent uptake in nursing and healthcare research.Reporting MethodNot applicable.Patient and Public ContributionNo patient or public contribution.