Comparison between audio-vestibular findings and contrast-enhanced MRI of inner ear in patients with unilateral Ménière’s disease

Leng, Yangming; Fan, Wenliang; Liu, Yingzhao; Xia, Kaijun; Zhou, Renhong; Liu, Jingjing; Wang, Hongchang; Ma, Hui; Liu, Bo

doi:10.3389/fnins.2023.1128942

Cited by 5 publications

(5 citation statements)

References 68 publications

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“…We then subsequently assessed the relationship between the affected side, the side presence of EH on CE-MRI, and the direction of nystagmus. The MD-affected side of all the patients was determined using a flowchart based on a questionnaire on cochlear symptoms during vertigo attacks and the results of various clinical examinations ( Figure 4 ) ( 14–16 ). The measurement method for electrocochleography and glycerol vestibular evoked myogenic potential (GVEMP) followed previously reported protocols ( 17 , 18 ).…”

Section: Methodsmentioning

confidence: 99%

Stratification of patients with Menière’s disease based on eye movement videos recorded from the beginning of vertigo attacks and contrast-enhanced MRI findings

Ueno,

Imai,

Higashi-Shingai

et al. 2024

Front. Neurol.

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PurposeDiagnosis of Menière’s disease (MD) relies on subjective factors and the patients diagnosed with MD may have heterogeneous pathophysiologies. This study aims to stratify MD patients using two objective data, nystagmus videos and contrast-enhanced magnetic resonance imaging (CE-MRI).MethodsThis is a retrospective cross-sectional study. According to the Japan Society for Equilibrium Research criteria (c-JSER), adults diagnosed with definite MD and who obtained videos recorded by portable nystagmus recorder immediately following vertigo attacks and underwent CE-MRI of the inner ear were included (ss = 91). Patients who obtained no nystagmus videos, who had undergone sac surgery, and those with long examination intervals were excluded (n = 40).ResultsThe gender of the subjects was 22 males and 29 females. The age range was 20–82 y, with a median of 54 y. Endolymphatic hydrops (EH) were observed on CE-MRI in 84% (43 patients). Thirty-one patients had unilateral EH. All of them demonstrated EH on the side of the presence of cochlear symptoms. The number of patients who had both nystagmus and EH was 38. Five patients only showed EH and 5 patients only exhibited nystagmus, while 3 patients did not have either. Of the 43 nystagmus records, 32 showed irritative nystagmus immediately after the vertigo episode. The direction of nystagmus later reversed in 44% of cases over 24 h.ConclusionPatients were stratified into subgroups based on the presence or absence of EH and nystagmus. The side with cochlear symptoms was consistent with EH. The c-JSER allows for the diagnosis of early-stage MD patients, and it can be used to treat early MD and preserve hearing; however, this approach may also include patients with different pathologies.

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Section: Methodsmentioning

confidence: 99%

Stratification of patients with Menière’s disease based on eye movement videos recorded from the beginning of vertigo attacks and contrast-enhanced MRI findings

Ueno,

Imai,

Higashi-Shingai

et al. 2024

Front. Neurol.

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“…The detailed procedures of audio-vestibular evaluations have been described in our previous studies 34 , which included the pure tone audiometry, electrocochleogram (ECochG), glycerol test, caloric test. The audio-vestibular tests were performed within an interval of 3 days.…”

Section: Methodsmentioning

confidence: 99%

“…Subjects with MR abnormalities, such as otitis media, acoustic neuroma, and brain tumors, were excluded from the analysis. Intratympanic Gd injection and MRI examination was performed as previously described 34 . The Gd-DTPA-dimeglumine solution (MultiHance; Braccosine, Shanghai, China) was used as the contrast agent.…”

Section: Methodsmentioning

confidence: 99%

Functional reorganization of intranetwork and internetwork connectivity in patients with Ménière’s disease

Li,

Leng,

et al. 2023

Sci Rep

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Ménière’s disease (MD) is associated with functional reorganization not only in the auditory or sensory cortex but also in other control and cognitive areas. In this study, we examined intranetwork and internetwork connectivity differences between 55 MD patients and 70 healthy controls (HC) in 9 well-defined resting-state networks. Functional connectivity degree was lower in MD compared to HC in 19 brain areas involved in the somatomotor, auditory, ventral attention, default mode, limbic, and deep gray matter networks. In addition, we observed lower intranetwork connectivity in the auditory, ventral attention, and limbic networks, as well as lower internetwork connectivity between the somatomotor and limbic networks, and between the auditory and somatomotor, deep gray matter, and ventral attention networks, and between the deep gray matter and default mode network. Furthermore, we identified 81 pairs of brain areas with significant differences in functional connectivity between MD patients and HC at the edge level. Notably, the left amygdala’s functional connectivity degree was positively correlated with MD’s disease stage, and the ventral attention network’s intranetwork connectivity was positively correlated with the healthy side vestibular ratio. Our findings suggest that these functional network reorganization alterations may serve as potential biomarkers for predicting clinical progression, evaluating disease severity, and gaining a better understanding of MD’s pathophysiology. Large-scale network studies using neuroimaging techniques can provide additional insights into the underlying mechanisms of MD.

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“…The electrocochleogram, caloric test and cervical vestibular‐evoked myogenic potential are tools in the assessment of EH 5–8 of the affected ear. However, as gadolinium‐enhanced magnetic resonance imaging (MRI) of the inner ear has matured in recent years, it has become increasingly utilised for clinical and differential diagnosis of common inner ear illnesses, including for the detection of EH 9,10 …”

Section: Introductionmentioning

confidence: 99%

“…However, as gadolinium-enhanced magnetic resonance imaging (MRI) of the inner ear has matured in recent years, it has become increasingly utilised for clinical and differential diagnosis of common inner ear illnesses, including for the detection of EH. 9,10 In clinical practice, gadolinium-enhanced MRI of the inner ear is likely to show EH in patients with sudden hearing loss (SHL) symptoms, particularly those who have tinnitus, aural fullness and vertigo.…”

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confidence: 99%

The value of gadolinium‐enhanced MRI in predicting the development of sudden hearing loss into Ménière's disease

Cai,

Xiao,

Lin

et al. 2023

Clinical Otolaryngology

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ObjectiveTo compare the clinical features of sudden hearing loss (SHL) in patients with and without endolymphatic hydrops (EH), and to investigate the association between SHL with EH and Ménière's disease (MD).MethodsThe clinical data of 63 SHL patients with first symptoms were evaluated retrospectively. Patients were separated into two groups based on the results of gadolinium‐enhanced magnetic resonance imaging: EH and non‐EH groups. Independent sample t‐test and U‐test were used to compare groups for continuous variables, and the chi‐squared test, corrected chi‐squared test and Bonferroni correction test were used to compare groups for binary and ordinal variables. The binary logistic regression model was utilised for univariate and multivariate analysis of follow‐up patient prognosis.ResultsThe EH and non‐EH groups contained 32 and 31 patients, respectively. The EH group had a higher prevalence of low‐tone descending hearing loss. Fifty‐one patients were followed for more than 2 years. In the EH group, 11 and 15 patients were diagnosed with sudden sensorineural hearing loss (SSNHL) and MD, respectively, while in the non‐EH group, 24 patients were diagnosed with SSNHL and only one with MD. EH, low‐tone descending hearing loss and vertigo were risk factors for the diagnosis of MD in a subgroup univariate regression analysis of patients experiencing SHL. EH was found to be a risk factor for the progression of SHL into MD in a multifactor regression analysis.ConclusionsPatients with SHL who have EH are more likely to present with low‐tone descending hearing loss. EH is a risk factor for the subsequent development of MD.

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Comparison between audio-vestibular findings and contrast-enhanced MRI of inner ear in patients with unilateral Ménière’s disease

Cited by 5 publications

References 68 publications

Stratification of patients with Menière’s disease based on eye movement videos recorded from the beginning of vertigo attacks and contrast-enhanced MRI findings

Stratification of patients with Menière’s disease based on eye movement videos recorded from the beginning of vertigo attacks and contrast-enhanced MRI findings

Functional reorganization of intranetwork and internetwork connectivity in patients with Ménière’s disease

The value of gadolinium‐enhanced MRI in predicting the development of sudden hearing loss into Ménière's disease

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