Background: Many patients with chronic idiopathic axonal polyneuropathy (CIAP) suffer from
neuropathic pain, which is managed using several oral medications and modalities. However,
despite these treatments, pain persists in some patients.
Objective: In the clinical field, clinicians frequently meet patients with neuropathic pain caused
by CIAP. The authors investigated the effect of caudal epidural pulsed radiofrequency (PRF) for the
management of CIAP-induced refractory neuropathic pain.
Study Design: This is a prospective study.
Setting: The outpatient clinic of a single academic medical center in Korea
Methods: Twenty patients with neuropathic pain and a diagnosis of refractory CIAP were recruited.
For PRF stimulation, a 22-gauge cannula was inserted into the epidural space through the sacral hiatus
under fluoroscopic guidance. PRF stimulation was administered once at 5 Hz with a 5-ms pulse width
for 600 seconds at 55 V. The effect of stimulation was evaluated using a numeric rating scale (NRS) at
2 weeks and 1, 2, and 3 months after the procedure. Successful pain relief was defined as a reduction
in the NRS score of ≥ 50% as compared with the score prior to treatment. In addition, at 3 months
after treatment, patient satisfaction levels were examined; patients that reported “very good” (score
= 7) or “good” (score = 6) results were considered to be satisfied with the procedure.
Results: Neuropathic pain was significantly reduced at 2 weeks and at 1, 2, and 3 months followup after PRF (P < 0.001, repeated measures one-factor analysis). In addition, at 3 months post-PRF,
half of the patients achieved a successful response (≥ 50% pain reduction) and were satisfied with
treatment results.
Limitations: A small number of patients were recruited, and we did not perform long-term
follow-up.
Conclusion: Caudal epidural PRF may be a good treatment option for managing neuropathic pain
induced by CIAP, especially when pain is unresponsive to oral medications.
Key words: Pulsed radiofrequency, chronic idiopathic axonal neuropathy, caudal epidural
stimulation, neuropathic pain chronic pain, refractory pain