Comparison between bone–implant interfaces of microtopographically modified zirconia and titanium implants

Thu, Myint Kyaw; Kang, Young Suk; Kwak, Jeong Min; Jo, Ye-Hyeon; Han, Jung‐Suk; Yeo, In‐Sung

doi:10.1038/s41598-023-38432-y

Cited by 4 publications

(1 citation statement)

References 50 publications

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“…Bone apposition to zirconia implants is similar to titanium implants [42][43][44] and also displays high wear-resistant and corrosion-resistant properties [45]. Surface modifications to zirconia implants, such as sandblasting, may also enhance bone integration to its surface [46]. Therefore, the bone-to-implant interface presents a unique biological situation and identifying factors from a multi-stable and hysteresis perspective that influence the structure of this interface are key to understanding the pathogenesis of peri-implantitis.…”

Section: Bone Biologymentioning

confidence: 99%

A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis

Ng,

Tay,

Mattheos

et al. 2024

Cells

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This mapping review highlights the need for a new paradigm in the understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on the relationship between biofilm, inflammation, and bone biology. The close interactions between immune and bone cells are discussed, with multiple stable states likely existing between clinically observable definitions of peri-implant health and peri-implantitis. The framework presented aims to explain the transition from health to disease as a staged and incremental process, where multiple factors contribute to distinct steps towards a tipping point where disease is manifested clinically. These steps might be reached in different ways in different patients and may constitute highly individualised paths. Notably, factors affecting the underlying biology are identified in the pathogenesis of peri-implantitis, highlighting that disruptions to the host–microbe homeostasis at the implant–mucosa interface may not be the sole factor. An improved understanding of disease pathogenesis will allow for intervention on multiple levels and a personalised treatment approach. Further research areas are identified, such as the use of novel biomarkers to detect changes in macrophage polarisation and activation status, and bone turnover.

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Section: Bone Biologymentioning

confidence: 99%

A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis

Ng,

Tay,

Mattheos

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

Review: osseointegration of titanium-based and zirconia implants: novel perspective on features, influencing factors and improvements

Ji,

Zhang,

Hou

et al. 2024

J Mater Sci

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Mechanism research of elastic fixation promoting fracture healing based on proteomics and fracture microenvironment

Wu,

Zhao,

Wang

et al. 2024

Bone Joint Res

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AimsThis study aimed to demonstrate the promoting effect of elastic fixation on fracture, and further explore its mechanism at the gene and protein expression levels.MethodsA closed tibial fracture model was established using 12 male Japanese white rabbits, and divided into elastic and stiff fixation groups based on different fixation methods. Two weeks after the operation, a radiograph and pathological examination of callus tissue were used to evaluate fracture healing. Then, the differentially expressed proteins (DEPs) were examined in the callus using proteomics. Finally, in vitro cell experiments were conducted to investigate hub proteins involved in this process.ResultsMean callus volume was larger in the elastic fixation group (1,755 mm3 (standard error of the mean (SEM) 297)) than in the stiff fixation group (258 mm3 (SEM 65)). Pathological observation found that the expression levels of osterix (OSX), collagen, type I, alpha 1 (COL1α1), and alkaline phosphatase (ALP) in the callus of the elastic fixation group were higher than those of the stiff fixation group. The protein sequence of the callus revealed 199 DEPs, 124 of which were highly expressed in the elastic fixation group. In the in vitro study, it was observed that a stress of 200 g led to upregulation of thrombospondin 1 (THBS1) and osteoglycin (OGN) expression in bone marrow mesenchymal stem cells (BMSCs). Additionally, these genes were found to be upregulated during the osteogenic differentiation process of the BMSCs.ConclusionElastic fixation can promote fracture healing and osteoblast differentiation in callus, and the ability of elastic fixation to promote osteogenic differentiation of BMSCs may be achieved by upregulating genes such as THBS1 and OGN.Cite this article: Bone Joint Res 2024;13(10):559–572.

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Comparison between bone–implant interfaces of microtopographically modified zirconia and titanium implants

Cited by 4 publications

References 50 publications

A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis

A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis

Review: osseointegration of titanium-based and zirconia implants: novel perspective on features, influencing factors and improvements

Mechanism research of elastic fixation promoting fracture healing based on proteomics and fracture microenvironment

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