Comparison Between CKD-EPI Creatinine and MDRD Equations to Estimate Glomerular Filtration Rate in Kidney Transplant Patients

“…At the time of enrollment to the study, the following investigations were conducted for all participants: blood urea, serum creatinine, eGFR calculated using the CKD-EPI 2009 formula (eGFR = 141xmin (SCr/κ,1) α x max (SCr /κ,1) -1.209 x 0.993 Age x1.018 [if female]) [ 19 ], urine analysis, uPCR, serum albumin, international normalization ratio, total bilirubin, detection of serum HCV antibody, Hepatitis B surface antigen and HIV antibodies 1 and 2, HCV ribonucleic acid (RNA) quantitative PCR, rheumatoid factor (RF) and cryoglobulins. In addition, fundus examination to exclude diabetic or hypertensive retinopathy was conducted if needed.…”

Section: Methodsmentioning

confidence: 99%

Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis

Ibrahim

Abdelhamid²,

Lewis³

et al. 2022

PLoS ONE

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Objectives It is not known why only some hepatitis C virus (HCV) infected patients develop glomerulonephritis (GN). Therefore, we investigated the role of soluble complement regulators in the development of HCV associated GN. Methods Patients with HCV associated GN who were admitted to our nephrology unit between July 2016 and July 2018 were recruited to the study (group 1). Two other age and sex matched groups were studied as control groups: patients with HCV without GN (group 2) and healthy HCV negative volunteers (group 3). There were 26 participants in each of the three groups at the end of the recruitment period. An assay of serum fluid-phase complement regulators was performed using enzyme linked immunosorbent assay technique. Three complement single nucleotide polymorphisms (SNPs) were analyzed using real time polymerase chain reaction (Taqman; thermo fisher scientific): rs2230199 and rs1047286 for complement 3 (C3) and rs800292 for complement factor H (CFH). Results Serum levels of complement 4 binding protein (C4BP) were significantly lower in group 1 (median 70 ng/ml) than in groups 2 (median 88.8 ng/ml) and 3 (median 82.8 ng/ml) with p value of 0.007. The minor allele (allele A) of rs800292 for CFH was significantly higher in group 2 and group 3 (G 54% and A 46%) than in group 1 (G 73% and A 27%), p = 0.04. Conclusions Low C4BP levels are associated with GN in HCV infected patients. In addition, rs800292 SNP in CFH protects against GN in patients with HCV.

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“…Several renal and non-renal factors can alter serum creatinine concentrations, including tubular secretion, sex, age, physical activity, nutrition, and muscle mass (2,3). For this reason, to assess the presence of CKD, the alternate approach to assessing GFR should be equation-based creatinine (4).…”

Section: Introductionmentioning

confidence: 99%

“…Estimated GFR of creatinine equations is preferred to serum creatinine measurement because serum creatinine measurements are internationally standardized, simple, and inexpensive (3). The CG and MDRD equations have poor accuracy and precision and are not ideal for use in renal transplant populations (4). It was observed that the MDRD equation underestimated the measured GFR for values above 60 mL/min (5-7), which could be misclassified in CKD stages.…”

Section: Introductionmentioning

confidence: 99%

Performance of Creatinine and Cystatin C-Based Equations to Estimate Kidney Function in Renal Transplant Recipients

et al. 2023

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Background: Numerous equations are applied in order to estimate the glomerular filtration rate (GFR). Objectives: This study aimed to spot the optimal equation that accurately estimates GFR and, therefore, the chronic kidney disease (CKD) stage in renal transplant patients. Methods: This cross-sectional study was conducted on 58 renal transplant patients. Their venous blood samples were obtained for serum creatinine and cystatin C determination used to calculate estimated GFR (eGFR). The average contrast of GFR in each equation was calculated using the Bland-Altman method. The correlation, bias, imprecision, and 10% and 30% accuracy were compared between the eGFR cystatin C and creatinine. Concordance between both equations for CKD staging was assessed. The classification of patients was also investigated. Results: Bland-Altman plots and bias demonstrated that eGFR by the abbreviated modification of diet in renal disease (Ab-MDRD) was the most accurate compared with chronic kidney disease epidemiology collaboration (CKD-EPI) cystatin C, followed by CKD-EPI eGFR creatinine. With reference to CKD-EPI cystatin C, the imprecision of the equations was approximately similar to Ab-MDRD, and CKD-EPI creatinine is still better than the Cockcroft-gault (CG) formula. They also showed good 30% accuracy. Finally, our finding suggested that Ab-MDRD and CKD-EPI eGFR creatinine might be the best-performing equation in the classification of the CKD stages in a cutoff of 60 mL/min/1.73 m2. Conclusions: Due to the high cost and potential delay in measuring cystatin C, it would be much more appropriate to measure Ab-MDRD; after that, CKD-EPI eGFR creatinine as an alternative approach in order to facilitate rapid clinical decision in renal transplant patients.

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Comparison Between CKD-EPI Creatinine and MDRD Equations to Estimate Glomerular Filtration Rate in Kidney Transplant Patients

Cited by 10 publications

References 23 publications

Correlation of Glomerular Size With Donor–Recipient Factors and With Response to Injury

Correlation of Glomerular Size With Donor–Recipient Factors and With Response to Injury

Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis

Performance of Creatinine and Cystatin C-Based Equations to Estimate Kidney Function in Renal Transplant Recipients

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