Comparison between clinical and computational method of surface measurements of skin ulcers caused by Cutaneous Leishmaniasis

Viloria, C.

doi:10.7149/opa.55.1.51084

Cited by 1 publication

(3 citation statements)

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“…The conventional procedure for wound healing assessment is based on a manual ruler method (a non-3D method), which is suggested in many medical wound care guidelines and specialized communities [6,7]. Some initial results of comparing measurements of surface area 3D reconstruction against the non-3D CL clinical conventional method were presented in [15].…”

Section: Oxygen Saturation and Vf Bloodmentioning

confidence: 99%

“…This is the case with CL, which is present mainly in low-income rural areas. Therefore, the equipment to monitor the healing of the ulcer is expected to be easy to transport and is expected to work in harsh environmental conditions (high humidity and high temperature) [15].…”

Section: Introductionmentioning

confidence: 99%

“…Both 3D-surface reconstruction and optical properties could allow for better understanding and follow-up of the illness. This could avoid unnecessary dosages of medication being provided to the patient, reducing possible side effects [15].…”

Section: Introductionmentioning

confidence: 99%

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Temporal Evaluation of the Surface Area of Treated Skin Ulcers Caused by Cutaneous Leishmaniasis and Relation with Optical Parameters in an Animal Model: A Proof of Concept

Londoño

Viloria

Pérez-Buitrago

et al. 2023

Sensors

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Cutaneous leishmaniasis (CL) is a neglected disease caused by an intracellular parasite of the Leishmania genus. CL lacks tools that allow its understanding and treatment follow-up. This article presents the use of metrical and optical tools for the analysis of the temporal evolution of treated skin ulcers caused by CL in an animal model. Leishmania braziliensis and L. panamensis were experimentally inoculated in golden hamsters, which were treated with experimental and commercial drugs. The temporal evolution was monitored by means of ulcers’ surface areas, as well as absorption and scattering optical parameters. Ulcers’ surface areas were obtained via photogrammetry, which is a procedure that allowed for 3D modeling of the ulcer using specialized software. Optical parameters were obtained from a spectroscopy study, representing the cutaneous tissue’s biological components. A one-way ANOVA analysis was conducted to identify relationships between both the ulcers’ areas and optical parameters. As a result, ulcers’ surface areas were found to be related to the following optical parameters: epidermis thickness, collagen, keratinocytes, volume-fraction of blood, and oxygen saturation. This study is a proof of concept that shows that optical parameters could be associated with metrical ones, giving a more reliable concept during the assessment of a skin ulcer’s healing.

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Section: Oxygen Saturation and Vf Bloodmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%