Comparison between dexmedetomidine and acepromazine in combination with methadone for premedication in brachycephalic dogs undergoing surgery for brachycephalic obstructive airway syndrome

Petruccione, Ilaria; Murison, PJ; Flaherty, Derek; Auckburally, Adam

doi:10.1016/j.vaa.2020.09.008

Cited by 7 publications

(7 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2010, Petruccione et al . 2021). Alpha‐2‐adrenoreceptor agonist‐induced vasoconstriction may offer some protection against hypotension during GA.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a prospective randomised crossover study of six dogs undergoing isoflurane anaesthesia identified that hypotension was prevented by preanaesthetic medication with dexmedetomidine when compared to acepromazine (Grasso et al 2015). Other studies have not identified differences in the incidence of hypotension under GA when comparing the use of alpha-2 agonists and acepromazine for pre-anaesthetic medication (Grint et al 2010, Petruccione et al 2021. Alpha-2-adrenoreceptor agonist-induced vasoconstriction may offer some protection against hypotension during GA.…”

mentioning

confidence: 99%

“…Alpha-2-adrenoreceptor agonist-induced vasoconstriction may offer some protection against hypotension during GA. The greater degree of sedation reported in comparison to acepromazine (Petruccione et al 2021) may permit greater reductions in inhalant anaesthetic agent requirements and the dosedependent cardiovascular depression associated with their use.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Association between body mass and hypotension in dogs under general anaesthesia

Miller,

Duncan,

Handel

et al. 2023

J of Small Animal Practice

View full text Add to dashboard Cite

ObjectivesTo investigate the association between body mass and hypotension during general anaesthesia in dogs undergoing surgical and diagnostic procedures within a referral hospital.Materials and MethodsRetrospective evaluation of the anaesthetic records of 1789 dogs was performed. Data on signalment, anaesthetic protocol and physiological variables, including mean arterial pressure, were collected. A multivariable generalised linear model was used to identify associations between explanatory variables, including body mass, and hypotension.ResultsIn the population studied, increasing body mass (per 10 kg) was significantly associated with decreasing odds of hypotension (odds ratio 0.68; 95% confidence interval: 0.60 to 0.77). Additional variables associated with a decreased odds of hypotension were pre‐anaesthetic medication with alpha‐2 agonists (odds ratio 0.63; 95% confidence interval 0.48 to 0.82) and increased body temperature (per 1°C) during general anaesthesia (odds ratio 0.77; 95% confidence interval 0.67 to 0.88). Brachycephaly (odds ratio 1.72; 95% confidence interval 1.25 to 2.38), ASA physical status classification >3 (odds ratio 2.03; 95% confidence interval 1.16 to 3.56), undergoing a surgical procedure (versus diagnostic) (odds ratio 1.57; 95% confidence interval 1.10 to 2.23) and bradycardia (odds ratio 1.37; 95% confidence interval 1.05 to 1.80) were independently associated with increased odds of hypotension.Clinical significanceDogs of lower body mass and brachycephalic breeds may be at higher risk of hypotension during general anaesthesia or alternatively represent subpopulations in which accurate blood pressure measurement presents a greater challenge. Monitoring blood pressure accurately in these groups requires particular attention and provisions for treating hypotension should be readily accessible.

show abstract

“…2010, Petruccione et al . 2021). Alpha‐2‐adrenoreceptor agonist‐induced vasoconstriction may offer some protection against hypotension during GA.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Association between body mass and hypotension in dogs under general anaesthesia

Miller,

Duncan,

Handel

et al. 2023

J of Small Animal Practice

View full text Add to dashboard Cite

show abstract

“…Eine neuere Studie zur Anwendung von Dexmedetomidin (2 µg/kg, n = 20) oder Acepromazin (20 µg/kg, n = 20, in beiden Gruppen in Kombination mit 0,3 mg/kg KM Methadon i.m) zur Sedation brachyzephaler Hunde zeigt gut die Unterschiede und damit die Vor- und Nachteile 3 . Die Hunde unter Acepromazin waren weniger tief aber länger sediert und benötigten etwas mehr Propofol zur Einleitung.…”

Section: Sedative Prämedikationunclassified

Anästhesie – traditionell oder aktuell?

Alef¹

2023

kleintier konkret

View full text Add to dashboard Cite

“…Häufig lassen sich solche theoretischen Vor- und Nachteile von einzelnen Wirkstoffen klinisch jedoch nicht sicher nachweisen. Eine klinische, prospektive, randomisierte Blindstudie 5 beschäftigte sich u. a. konkret mit den Effekten von Acepromazin oder Dexmedetomidin auf den MDT von brachyzephalen Hunden (ASA 2, Vorstellung zur Atemwegschirurgie), da bei dieser Patientengruppe die Probleme Regurgitation bzw. gastroösophagealer Reflux eine große Rolle spielen.…”

Section: Wirkung Verschiedener Wirkstoffe Auf Den Mdtunclassified

Magen-Darm-Trakt und Anästhesie – Auch da gibt es einiges zu beachten!

Alef

2023

kleintier konkret

View full text Add to dashboard Cite

Comparison between dexmedetomidine and acepromazine in combination with methadone for premedication in brachycephalic dogs undergoing surgery for brachycephalic obstructive airway syndrome

Cited by 7 publications

References 30 publications

Association between body mass and hypotension in dogs under general anaesthesia

Association between body mass and hypotension in dogs under general anaesthesia

Anästhesie – traditionell oder aktuell?

Magen-Darm-Trakt und Anästhesie – Auch da gibt es einiges zu beachten!

Contact Info

Product

Resources

About