Comparison between dexmedetomidine and remifentanil for controlled hypotension during tympanoplasty

Richa, Freda; Yazigi, Alexandre; Sleilaty, Ghassan; Yazbeck, Patricia

doi:10.1017/s0265021508003761

Cited by 64 publications

(57 citation statements)

References 24 publications

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“…In our patients, the addition of dexmedetomidine to bupivacaine causes a significant decrease in the MAP and HR intra-operatively. Similar result was recorded that the effect of single dose of 0.5 μg/kg dexmedetomidine administered 10 min before induction of anesthesia and reported significant reduction in MAP and HR [22,23]. Al-Ghanem et al [9] have reported the use of dexmedetomidine to be associated with a decrease in heart rate and mean blood pressure.…”

Section: Discussionsupporting

confidence: 64%

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Mohamed¹,

Salem²

2015

J Anesth Clin Res

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Section: Discussionsupporting

confidence: 64%

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Mohamed¹,

Salem²

2015

J Anesth Clin Res

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“…7 Além disso, tem efeito descongestionante e induz a hipotensão em timpanoplastias. 8,9 Dexmedetomidina também foi usada em pacientes submetidos à CES sob anestesia local, 10,11 bem como em pacientes submetidos à septoplastia e timpanoplastia sob anestesia geral. Há relato de que dexmedetomidina diminui o escore de sangramento e reduz a quantidade necessária de fentanil.…”

Section: Introductionunclassified

Comparação dos efeitos de sulfato de magnésio e da dexmedetomidina sobre a qualidade da visibilidade em cirurgia endoscópica sinusal: estudo clínico randomizado

Akkaya

Tekelioğlu

Demırhan

et al. 2014

Brazilian Journal of Anesthesiology

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“…Dexmedetomidine sympatholytic action is manifested by dose-dependent decrease in arterial blood pressure, heart rate, cardiac output and norepinephrine release [30]. This was coinciding with Basar and his colleagues [31] who investigated the effect of single dose of dexmedetomidine and reported significant reduction in MAP and HR.…”

Section: Discussionmentioning

confidence: 59%

Cerebral oxygen saturation monitoring during hypotensive anesthesia in shoulder arthroscopy: A comparative study between dexmedetomidine and esmolol

Maghawry

Elagamy

Tahir

et al. 2015

Egyptian Journal of Anaesthesia

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Background: Beach chair position (BCP) is used in arthroscopic shoulder operations for its advantages. The BCP together with deliberate hypotension used to decrease intraoperative blood loss during arthroscopic shoulder procedures, this may have risk to cause postoperative neurological insults. Dexmedetomidine and esmolol are used to induce deliberate hypotension. Near-infrared spectroscopy (NIRS) provides a non-invasive technique of continuous monitoring of regional cerebral tissue oxygen saturation (rScO 2 ). In this study we evaluate the prevalence of rScO 2 during hypotensive anesthesia induced by intra-operative infusion of either dexmedetomidine or esmolol in patients undergoing elective arthroscopic shoulder surgery in the BCP. Patients and methods: Fifty patients scheduled for elective arthroscopic shoulder surgery under general anesthesia with hypotensive technique in BCP, randomly assigned into two equal groups, dexmedetomidine group (D Group) and esmolol group (E Group) according to the drug used for deliberate hypotension. MAP, HR, BIS and rS c O 2 were recorded before induction of anesthesia T 0 , post-induction of anesthesia T 1 as baseline, 5 min after BCP T 2 , 5 min after starting the studied drug T 3 , 30 min T 4 , 60 min T 5 , 90 min T 6 , 5 min after stopping the studied drug T 7 , 5 min after return to supine T 8 and after extubation T 9 . Results: In D group there was significant decrease in Lt.rs c o 2 and Rt.rs c o 2 , at T2 to T7 compared to T1. In E group there was significant decrease in Lt.rs c o 2 and Rt.rs c o 2 at T2, to T7 compared to T1. In D group two patients had CDEs compared to five patients in E group. Conclusion: In patients undergoing shoulder arthroscopic surgery under general anesthesia, the BCP significantly decreases rS c O 2 , with further slight decrease of rS c O 2 with dexmedetomidine and esmolol induced hypotension with no affection of postoperative cognitive function with both drugs. Dexmedetomidine and esmolol are safe drugs with better safety of dexmedetomidine over esmolol.

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Comparison between dexmedetomidine and remifentanil for controlled hypotension during tympanoplasty

Abstract: Infusion of dexmedetomidine, at the doses used in this study, was less effective than remifentanil in achieving controlled hypotension, good surgical field exposure condition and surgeons' satisfaction during tympanoplasty.

Cited by 64 publications

References 24 publications

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Bupivacaine-Dexmedetomidine for Lumber Discectomy: Randomized Controlled Placebo Study

Comparação dos efeitos de sulfato de magnésio e da dexmedetomidina sobre a qualidade da visibilidade em cirurgia endoscópica sinusal: estudo clínico randomizado

Cerebral oxygen saturation monitoring during hypotensive anesthesia in shoulder arthroscopy: A comparative study between dexmedetomidine and esmolol

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