Comparison Between Discriminant Analysis Models and “Glaucoma Probability Score” for the Detection of Glaucomatous Optic Nerve Head Changes

Iester, Michele; Perdicchi, Andrea; Capris, Elisabetta; Siniscalco, Andrea; Calabria, G.; Recupero, Santi Maria

doi:10.1097/ijg.0b013e3181622568

Cited by 21 publications

(14 citation statements)

References 20 publications

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“…No significant associations were found between IOP and HRT parameters except for GPS (ONL) confirming partially previous OHTS results (Zangwill et al 2004). The ability of the GPS to discriminate between normal and glaucomatous eyes has been evaluated extensively in the literature (De Leon-Ortega et al 2007;Alencar et al 2008;Ferreras et al 2008;Iester et al 2008). There is a general consensus that it is at least as effective as MRA and has the advantage that it is contour line drawing independent.…”

Section: Discussionsupporting

confidence: 76%

The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors

Miglior

Zeyen

Torri

et al. 2013

Acta Ophthalmologica

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ABSTRACT.Purpose: To describe the study design and baseline factors of the Heidelberg Retina Tomograph ancillary study within the EGPS. Furthermore, to examine the relationship between HRT optic disc topographic measurements and baseline demographic and ocular factors. Methods: Four hundred and eighty-nine ocular hypertensive participants were included. Each participant completed HRT imaging at least annually. The associations between HRT measurements and IOP, central corneal thickness (CCT), baseline photographic estimates of vertical CDR ratio (CDR), asymmetry between the two eyes in CDR ratio and baseline visual field indices were assessed using regression analysis. Results: Associations between HRT measurements and vertical CDR by photographs were found for almost all stereometric optic disc parameters in both univariate and multivariate analysis. The strongest association was found between vertical CDR measurements and disc, cup and rim area; cup and rim volume, CDR area, linear CDR, mean and maximum cup depth and cup shape measure (all p < 0.0001). In multivariate analysis, pattern standard deviation (PSD) and HRT disc area had significant associations with several HRT optic disc measurements. Furthermore, CCT was significantly associated with reference height and the glaucoma probability score (GPS, outside normal limits). Conclusions: The EGPS is the first multicentre, placebo-controlled randomized clinical trial to use HRT for monitoring optic disc changes in participants with ocular hypertension. We found strong associations between stereophotographic vertical CDR estimates, HRT disc area, PSD and several HRT parameters. We found, furthermore, that the parameters reference height and GPS were significantly related to central corneal thickness.

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Section: Discussionsupporting

confidence: 76%

The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors

Miglior

Zeyen

Torri

et al. 2013

Acta Ophthalmologica

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“…The ONH was then divided into 6 sectors: temporal sector [with angular extend from À45 to + 45 degrees (T)], temporal-superior sector [from +45 to + 90 degrees (TS)], temporal-inferior sector [from 270 to 315 degrees (TI)], nasal sector [from + 135 to +225 degrees (N)], nasalsuperior sector [from + 90 to +135 degrees (NS)], and nasal-inferior sector [from 225 to 270 degrees (NI)]. 20 According to Jonas et al's classification [inferior (247.5 to 337.5 degrees), superior (22.5 to 112.5 degrees), and temporal (337.5 to 22.5 degrees)], the optic disc was divided into 4 special quadrants: the temporal sector was between 315 to 45 degrees, superior sector (TS+NS) was 45 to 135 degrees, nasal between 135 and 225 degrees and inferior (TI+NI) between 225 to 315 degrees. In this study, the superior and inferior sectors were not rotated temporally as already described and were used by Iester et al's studies.…”

Section: Heidelberg Retina Tomographmentioning

confidence: 99%

“…[12][13][14][15][16][17] The Heidelberg Retina Tomograph 3 (HRT3, Heidelberg Engineering, Heidelberg, Germany; software version 3.1.2) was a confocal scanning laser for measuring and analyzing ONHs 3-dimensionally. [18][19][20] In the last HRT version (version 3.1.2) there is the "ISN'T rule" to distinguish healthy ONHs from glaucomatous ONHs. The aim of this study was to assess whether the rim shape as measured by HRT3 followed Jonas et al's ISN'T rule or any other specific distribution pattern.…”

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confidence: 99%

The “ISN'T Rule” in Healthy Participant Optic Nerve Head by Confocal Scanning Laser Ophthalmoscopy

Iester

Bertolotto²,

Recupero³

et al. 2011

Journal of Glaucoma

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“…Glaucoma is a multifactorial neurodegenerative disorder characterized by progressive structural and functional injury of the optic nerve complex (optic nerve and parapapillary region) 1–7. Evaluation of visual field (VF) damage remains the major index of the functional impact of glaucoma, and the assessment of its progression has a direct effect on therapeutic decisions and the quality of life of patients 8–13.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the progression of visual field damage in patients suffering from early manifest glaucoma

Perdicchi¹,

Abdolrahimzadeh²,

Cutini³

et al. 2016

OPTH

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BackgroundThis retrospective study aimed to determine how often a perimetric examination should be carried out in order to identify visual field (VF) changes in patients with relatively early manifestation glaucoma.Materials and methodsPatients included had a relatively recent manifestation of primary open-angle glaucoma. Patients with a minimum follow-up of 5 years and a minimum of seven VF tests were included. Statistical analysis was performed to verify the trend of variations in mean defect (MD) over time (PeriData). The results were subjected to a t-test for a comparative analysis of progression of VF changes over time. The annual rate of progression provided by PeriData considering all the VFs analyzed was compared with that obtained on half of the VF examinations during the same follow-up period. An analysis of the MD trend over time was also carried out in relationship to the number of VF tests done and by dividing the sample into a high-frequency group (more than eight VFs) and a low-frequency group (fewer than eight VFs) in the follow-up period.ResultsA total of 96 eyes of 96 patients were included, and overall 846 VFs were examined. The paired t-test performed comparing the MD index of all the VFs against half of them did not show statistical significance (P=0.537). The high-frequency group comprised 39 eyes (average VF 11.05±1.91, average time interval 0.76 years) while the low-frequency group comprised 57 eyes (average VF 6.95±0.6, average time interval 1.21 years). The analysis of the MD trend in the high-frequency patients showed significance (P=0.017); the low-frequency group did not show statistical significance (P=0.08).ConclusionThe number of VFs in a determined time interval was not significant. However, a greater frequency of tests provides a predictive evaluation of the rate of progression of early manifestation open-angle glaucoma.

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Comparison Between Discriminant Analysis Models and “Glaucoma Probability Score” for the Detection of Glaucomatous Optic Nerve Head Changes

Abstract: The GPS showed similar sensitivity and specificity to the Mikelberg and Bathija formulas; this method is a promising one for differentiating between healthy and glaucomatous eyes, requiring no subjective user input.

Cited by 21 publications

References 20 publications

The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors

The Heidelberg retina tomograph ancillary study to the European glaucoma prevention study: study design and baseline factors

The “ISN'T Rule” in Healthy Participant Optic Nerve Head by Confocal Scanning Laser Ophthalmoscopy

Evaluation of the progression of visual field damage in patients suffering from early manifest glaucoma

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