Comparison between familial and sporadic systemic lupus erythematosus in Kuwaiti patients

Abutiban, Fatemah; Mokkaddam, K; Ameen, Edrees Mohammad; Moussa, Mohamed; Alsaeid, Khaled

doi:10.1177/0961203308094228

Cited by 17 publications

(21 citation statements)

References 12 publications

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“…The 5% prevalence of familial lupus observed in our study is similar to frequencies previously described [8;9] but lower than in studies of patients with high degree of consanguinity [10;20]. …”

Section: Discussionsupporting

confidence: 89%

“…Concordance rates are higher for monozygotic (24–56%) than dizygotic twins (2–5%); furthermore, a high degree of concordance in disease expression has been shown in some studies [3–6]. Despite the preponderance of lupus within families, studies conducted so far have failed to show distinctive immunological and clinical features between patients with sporadic and familial lupus [7–9] including studies conducted in populations with a high degree of consanguinity [8;10]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Is familial lupus different from sporadic lupus? Data from LUMINA (LXXIII), a multiethnic US cohort

Burgos

McGwin

Reveille

et al. 2010

Lupus

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Purpose To characterize the clinical features of familial lupus, and determine its influence on damage accrual and survival using data from LUMINA, a longitudinal multiethnic US cohort. Method Familial lupus was defined as patients with a first degree relative with SLE. Relative risks were estimated by logistic regression; odds ratios (OR) and their 95% confidence intervals (CI) were the measure of association for familial lupus. Hazard Ratios (HR) were calculated using Cox proportional hazard adjusted for potential confounders for damage and survival. Results Thirty-two of 644 patients had familial and 612 had sporadic lupus; both groups were of comparable age (~ 36 years). Familial lupus patients were in decreasing order of frequency siblings, parents and children. In multivariable analyses, mucosal ulcers (OR=1.92, 95% CI 0.65–5.70), mitral valve prolapse (OR=1.74, 95% CI 0.50–6.10), cerebrovascular disease (OR=4.18, 95% CI 0.98–17.76) and oral contraceptive use (ever/never; OR=2.51, 95% CI 0.88–7.19) were more likely in familial lupus but a history of low platelet count (<150,000/mm3; OR=0.31, 95% CI 0.08–1.17) and pulmonary disease activity (OR=0.39, 95% CI 0.14–1.20) were less likely. However, none of these associations reached statistical significance. Familial lupus was not significantly associated with a shorter time to either damage accrual or death (HR=0.77, 95% CI 0.37–1.59, p = 0.4746 and HR=0.20, 95% CI 0.03–1.47, p = 0.2020, respectively). Conclusions Although some clinical differences were observed in patients with familial and sporadic lupus, familial lupus was not associated with a significantly greater disease burden (damage, survival) than sporadic lupus.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Is familial lupus different from sporadic lupus? Data from LUMINA (LXXIII), a multiethnic US cohort

Burgos

McGwin

Reveille

et al. 2010

Lupus

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“…The rates of clotting disorders, seizures, and myocardial infarction were similar between the two groups [11,12]. In spite of the similarities of the clinical and serological manifestations between familial and non-familial SLE in adults SLE [13][14][15], it is not clear whether clinical and laboratory features of the FJSLE differ from those of sporadic cases; however, we found a marked difference in the origin of patients and the age of disease onset between the familial and sporadic SLE groups [16]. This study analyzed the clinical and laboratory features of 50 patients with FJSLE from 18 unrelated families seen in 3 tertiary health care centers in Saudi Arabia and Oman.…”

Section: Discussioncontrasting

confidence: 53%

Familial juvenile systemic lupus erythematosus in Arab children

Al‐Mayouf¹,

Abdwani²,

Al-Brawi³

2011

Rheumatol Int

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A ten-year retrospective analysis of the clinical features and survival of 60 Saudi children with systemic lupus erythematosus (SLE) was made. All the patients fulfilled the 1982 American College of Rheumatology's revised criteria for SLE and had had the disease at or before the age of 16 years. The female to male ratio was 5:1, the mean age of onset was 12.1 years (range 1.6-16 years), and the mean duration of follow-up was 4.7 years (range 2.2-11). Thirty-eight patients (63%) were diagnosed correctly before referral to KFSH&RC or KKUH. The mode of presentation was as follows: 55 patients had musculoskeletal involvement (91.6%), 49 patients had skin involvement (81.6%), 40 patients had hematological abnormalities (66.6%), 39 patients had renal disease (65%), 10 patients had pulmonary involvement (16%), 23 patients had cardiovascular disease (38%) and 18 patients had central nervous system involvement. During the study period four patients died (6.6%)-two of renal failure, one from meningitis and one from severe sepsis. This is the largest collection of childhood systemic lupus erythematosus from the Middle East and it shows that SLE is more common in Saudis than was hitherto believed, and that it has a high rate of organ involvement.

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“…These results could suggest that consanguinity may be the cause of higher prevalence of SLE in Saudi Arabia compared with developed countries [3]. In one study from Kuwaiti population [14], which is also considered highly consanguineous, the prevalence of familial SLE was 27.4%, which is almost identical to our results (27.7%; Table 2). …”

Section: Discussionsupporting

confidence: 80%

Familial Lupus and Clinical Characteristics in Saudi Arabia

Albishri¹,

Alshehri²,

Altowairqi³

et al. 2015

IJCM

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Background: It has been proven that a family history of systemic lupus erythematosus (SLE) is a risk factor for the development of the disease, and the risk increases with increasing number of relatives affected. In Saudi Arabia, high consanguinity rate leads to higher incidence of familial form than in other countries. We compare the percentage of familial versus sporadic SLE among Saudi patients. The second aim of the present study is to compare clinical characteristics between the two forms of the disease. Methods: This cross-sectional study includes 47 female patients whom are selected and investigated through three phases. We have added additional two categories of relatives, based on unconventional definition. We have examined and compared demographic characteristics of the patients with familial and sporadic SLE. We have also compared the percentage of familial vs. sporadic lupus and clinical characteristics of the two forms. Results: All the patients are females, aged between 18 and 43 years. The highest percentage of patients resides in the central region of Saudi Arabia (34%). The origin of the big family or tribe also most commonly occurs in the central region (34%). Data analysis results in 27.7% of patients with familial form of SLE. Sporadic form is found in 72.3% of patients. Consanguinity between patients' parents is noticed in both familial form (61.5%) and sporadic form (58.8%). Clinical manifestations are similar between patients with familial and sporadic form. Conclusion: Our results show a high percentage of familial lupus among Saudi patients. More research is required in order to estimate the inheritance pattern of familial SLE and involvement of genetic and environmental factors.

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Comparison between familial and sporadic systemic lupus erythematosus in Kuwaiti patients

Cited by 17 publications

References 12 publications

Is familial lupus different from sporadic lupus? Data from LUMINA (LXXIII), a multiethnic US cohort

Is familial lupus different from sporadic lupus? Data from LUMINA (LXXIII), a multiethnic US cohort

Familial juvenile systemic lupus erythematosus in Arab children

Familial Lupus and Clinical Characteristics in Saudi Arabia

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