Comparison Between GDx VCC Parameter and Achromatic Perimetry in Glaucoma Patients

Iester, Michele; Perdicchi, Andrea; Feo, F. De; Fiesoletti, E.; Amodeo, Stefano; Sanna, Giuseppe D; Leonardi, Antonella; Calabria, G.

doi:10.1097/01.ijg.0000212235.88416.bd

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…Another study applied a design similar to ours, except for not including MRI: Bowd et al 5 showed that VF sensitivity was associated with RNFL/optic disc measurements of up to r 2 ϭ 0.26 for SLT, r 2 ϭ 0.21 for SLP, and r 2 ϭ 0.38 for OCT. Hood et al 6 found r ϭ 0.82 for the upper hemifield and r ϭ 0.70 for the lower hemifield when comparing SAP with OCT. Iester et al 28 pointed out that, among other parameters, the NFI correlated best with the MD, as we noted in our multivariate analysis. Leung et al 15 observed a good concordance between OCT and SLP in POAG, with a slightly better correlation between MD and RNFL thickness when measured with OCT compared with SLP.…”

Section: Discussionsupporting

confidence: 65%

Retrobulbar Optic Nerve Diameter Measured by High-Speed Magnetic Resonance Imaging as a Biomarker for Axonal Loss in Glaucomatous Optic Atrophy

Lagrèze

Gaggl

Weigel

et al. 2009

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionsupporting

confidence: 65%

Retrobulbar Optic Nerve Diameter Measured by High-Speed Magnetic Resonance Imaging as a Biomarker for Axonal Loss in Glaucomatous Optic Atrophy

Lagrèze

Gaggl

Weigel

et al. 2009

Invest. Ophthalmol. Vis. Sci.

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“…There are significant differences, not only according to the instruments used, but also when the same instruments are used. For example, with HRT, few authors have obtained maximum correlations between 0.52 [15] and 0.77 [16], using GDF between −0.35 [17] and 0.78 [18] and using OCT between 0.51 [19] and 0.85 [20]. …”

Section: Discussionmentioning

confidence: 99%

Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma

González-Hernández

Sigut

Rosa

2017

Journal of Ophthalmology

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Purpose To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). Results The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R = 0.81 (P < 0.0001), similar to that between the BMO-MRW and BMO-RNFL thicknesses (R = 0.85, P < 0.0001) (P = 0.227 between both R values). GDF correlated well with RNFL thicknesses in the 360 degrees around the nerve, similar to mean perimetric sensitivity (MS) and BMO-MRW. The amount of hemoglobin in the nasal and temporal sectors showed low correlation with superior and inferior RNFL thicknesses. The superotemporal and inferotemporal sectors located on the vertical diameter of the disk showed good intercorrelation but without a clear RNFL topographic relationship. Conclusion GDF showed high correlation with RNFL thickness. Except in the nasal and temporal sectors, ONH hemoglobin correlated well with RNFL thickness.

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“…Reus and Lemij 26 found a significant correlation between GDx VCC retardation and the sensitivity as measured with the HFA. Iester et al 27 reported that some of the GDx VCC indices significantly correlated with visual field indices in glaucomatous patients (NFI, r=-0.35; superior average, r=0.28; TSNIT average, r=-0.24; inferior average, r=0.21). Our current result is in agreement with previous reports that stated that, in glaucomatous eyes, there was a significant correlation between a visual field index (MD and PSD) and some of the parameters yielded by GDx VCC.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Glaucomatous Retinal Nerve Fiber Damage by GDx VCC Polarimetry in Taiwan Chinese Population

Chen

Huang

2009

Journal of Optometry

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PURPOSE:To study the capability of scanning laser polarimetry with variable corneal compensation (GDx VCC) to detect differences in retinal nerve fiber layer thickness between normal and glaucomatous eyes in a Taiwan Chinese population. METHODS: This study included 44 normal eyes and 107 glaucomatous eyes. The glaucomatous eyes were divided into three subgroups on the basis of its visual field defects (early, moderate, severe). Each subject underwent a GDx-VCC exam and visual field testing. The area under the receiver-operating characteristic curve (AROC) of each relevant parameter was used to differentiate normal from each glaucoma subgroup, respectively. The correlation between visual field index and each parameter was evaluated for the eyes in the glaucoma group. RESULTS: For normal vs. early glaucoma, the parameter with the best AROC was Nerve fiber indicator (NFI) (0.942). For normal vs. moderate glaucoma, the parameter showing the best AROC was NFI (0.985). For normal vs. severe glaucoma, the parameter that had the best AROC was NFI (1.000). For early vs. moderate glaucoma, the parameter with the best AROC was NFI (0.732). For moderate vs. severe, the parameter showing the best AROC was temporal-superior-nasal-inferior-temporal average (0.652). For early vs. severe, the parameter with the best AROC was NFI (0.852). CONCLUSIONS: GDx-VCC-measured parameters may serve as a useful tool to distinguish normal from glaucomatous eyes; in particular, NFI turned out to be the best discriminating parameter. RESUMEN OBJETIVO: Estudiar la capacidad de la polarimetría láser de barrido con compensación corneal variable (dispositivo denominado GDx VCC) para detectar la diferencias de espesor de la capa de fibras nerviosas de la retina que existen entre ojos normales y ojos con glaucoma, en una población china de Taiwan. MÉTODOS: En este estudio se incluyeron 44 ojos normales y 107 ojos con glaucoma. El grupo de ojos con glaucoma se dividió, a su vez, en tres subgrupos según los defectos campimétricos encontrados (glaucoma temprano, moderado o grave). A cada sujeto se le realizaron medidas de GDx-VCC y una exploración del campo visual. Para discriminar entre el grupo normal (de control) y cada uno de los subgrupos con glaucoma se utilizó el área bajo la curva ROC (AROC) obtenida para cada parámetro de interés. Además, para los ojos con glaucoma se evaluó la correlación entre un índice del campo visual y cada uno de los parámetros obtenidos mediante GDx-VCC. RESULTADOS: Para la discriminación ojos normales -glaucoma temprano, el parámetro que proporcionó el AROC mejor o más elevado (valor=0,942) fue el indicador de fibras nerviosas (NFI). Para la diferenciación ojos normales -glaucoma moderado, el parámetro con el mejor AROC (igual a 0,985) fue el NFI. Para ojos normales -glaucoma grave, el parámetro con el mejor AROC fue el NFI (1,000). Para glaucoma temprano -moderado, el paráme-tro con el mejor AROC (valor=0,732) fue el NFI. Para la diferenciación glaucoma moderado -grave, el parámetro que proporcionó el mejor A...

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Comparison Between GDx VCC Parameter and Achromatic Perimetry in Glaucoma Patients

Abstract: Some of the GDx VCC indices were significantly correlated to visual field indices in glaucomatous patients, but NFI was the best indicator of visual field damage.

Cited by 10 publications

References 17 publications

Retrobulbar Optic Nerve Diameter Measured by High-Speed Magnetic Resonance Imaging as a Biomarker for Axonal Loss in Glaucomatous Optic Atrophy

Retrobulbar Optic Nerve Diameter Measured by High-Speed Magnetic Resonance Imaging as a Biomarker for Axonal Loss in Glaucomatous Optic Atrophy

Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma

Evaluating Glaucomatous Retinal Nerve Fiber Damage by GDx VCC Polarimetry in Taiwan Chinese Population

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