Comparison between High-Sensitivity C-Reactive Protein (hs-CRP) and White Blood Cell Count (WBC) as an Inflammatory Component of Metabolic Syndrome in Japanese

Oda, Eiji; Kawai, Ryu

doi:10.2169/internalmedicine.49.2670

Cited by 62 publications

(38 citation statements)

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“…3 and with MetS in a Japanese health screening population study. 10 In a previous study based on data from 1,062 men and 647 women, we proposed 0.45 mg/L for men and 0.25 mg/L for women as tentative optimal cutoff points of hs-CRP for MetS in Japanese. 18 Subsequently, we proposed 0.40 mg/L for men and 0.35 mg/L for women as the optimal cutoff points of hs-CRP as the inflammatory component of MetS, according to the results of a study of apparently healthy Japanese men (2,185) and women (1,383).…”

Section: Discussionmentioning

confidence: 99%

“…18 Subsequently, we proposed 0.40 mg/L for men and 0.35 mg/L for women as the optimal cutoff points of hs-CRP as the inflammatory component of MetS, according to the results of a study of apparently healthy Japanese men (2,185) and women (1,383). 10 However, there are some concerns about the reproducibility of the serum levels of hs-CRP, because hs-CRP increases hugely in acute inflammation and the effects continue for several days. Koenig et al suggested that the true association between hs-CRP and cardiovascular risk is underestimated by a single hs-CRP determination, and that serial measurements should be taken.…”

Section: Discussionmentioning

confidence: 99%

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Reproducibility of High-Sensitivity C-Reactive Protein as an Inflammatory Component of Metabolic Syndrome in Japanese

Oda

Kawai

2010

Circ J

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Background: Cutoff points for high-sensitivity C-reactive protein (hs-CRP) as a component of metabolic syndrome (MetS) in Japanese have been proposed as 0.40-0.45 mg/L for men and 0.25-0.35 mg/L for women. However, there are some concerns about the reproducibility of hs-CRP. Methods and Results:Reproducibility of hs-CRP as a component of MetS was examined using receiver-operating characteristic (ROC) curves for diagnosing MetS in 1,274 men and 673 women whose serum levels of hs-CRP were measured twice at annual health screening tests. The Spearman's correlation coefficient between baseline hs-CRP and hs-CRP at the next year's test was 0.68 in men and 0.71 in women. The area under the ROC curves of baseline hs-CRP, hs-CRP at the next year's test, and the mean of the 2 hs-CRP tests for diagnosing baseline MetS were 0.71, 0.71, and 0.72, respectively, in men and 0.75, 0.74, and 0.74, respectively, in women. Optimal cutoff points of baseline hs-CRP, hs-CRP at the next year's test, and the mean of 2 tests for diagnosing baseline MetS were all 0.40 mg/L in men and 0.35 mg/L in women. Conclusions:The serum level of hs-CRP was stable enough for use as a measure of the inflammatory component of MetS, and the optimal cutoff point of hs-CRP was 0.40 mg/L for men and 0.35 mg/L for women in a

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Reproducibility of High-Sensitivity C-Reactive Protein as an Inflammatory Component of Metabolic Syndrome in Japanese

Oda

Kawai

2010

Circ J

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“…The longitudinal data from the Framingham Heart Study have clearly shown that individuals with BPs of 120-139/80-89 mm Hg are at increased risk of developing full-blown HT and CVD later in life than individuals with BPs less than 120/80 mm Hg (2). Studies in the United States and other populations have identifi ed an association between increased WBC count and BP (15)(16)(17). The relationship between leukocytes and increased cardiovascular risk is well known.…”

Section: Discussionmentioning

confidence: 99%

Association between the neutrophil to lymphocyte ratio and prehypertension

Aydın¹,

Yuksel²,

Yıldız³

et al. 2015

BLL

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OBJECTIVES: To explore the neutrophil-lymphocyte ratio (NLR) in patients with prehypertension (PHT). BACKGROUND: Infl ammation plays an important role in the development of cardiovascular diseases. A pathophysiological link also exists between infl ammation and PHT. NLR is a simple marker for the assessment of infl ammatory status. There is a lack of data regarding the association between NLR and pre-hypertensive state. METHODS: The present cross-sectional study included 33 newly diagnosed PHT patients and 35 normotensive control subjects. Prehypertension was defi ned as a systolic blood pressure (BP) of 120-139 mm Hg and/or a diastolic BP of 80-89 mm Hg. RESULTS: Patients were divided into tertiles based on NLR values: 1.17 (0.9-1.42) in tertile 1; 1.57 (1.43-1.78) in tertile 2; and 2.40 (1.82-4.5) in tertile 3. The frequency of PHT was signifi cantly higher for patients in the upper NLR tertile compared to the middle and lower NLR tertiles (21 (91.3 %), 7 (30.4 %), and 5 (22.7 %), respectively; p < 0.001). Systolic BP and diastolic BP were signifi cantly higher among patients in the upper NLR tertile than among those in the other NLR tertiles. CONCLUSION: An association exists between PHT and NLR. NLR measurement, as well as monocyte count, may be used to indicate increased risk of prehypertension (Tab. 2, Ref. 48). Text in PDF www.elis.sk.

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“…WBC is an important maker of low-grade systemic inflammation which may be a central mechanism of MetS (22). High sensitive C-reactive protein (hs-CRP) is also a useful marker of systemic inflammation and an independent risk factor of diabetes, cardiovascular disease and MetS (23)(24)(25). It was reported that hs-CPR is superior to WBC as an inflammatory component of MetS (23).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Study on White Blood Cell Count and the Incidence of Metabolic Syndrome

et al. 2011

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Objective Many studies have revealed that white blood cell count (WBC) is related to insulin resistance which is a central mechanism of metabolic syndrome (MetS). However, few cohort studies have examined the role of WBC in the development of MetS. We hypothesized that WBC is associated with the future development of MetS, and investigated the longitudinal incidence of MetS in healthy workers. Methods WBC was measured in 5,073 workers (mean age 42.5 years) without MetS at baseline. The incidence of MetS was monitored over 7 years of follow-up, in relation to quartiles of WBC. During the followup, 925 participants were diagnosed as MetS. Results Incidence of MetS was increased in participants with higher WBC: the rates of incidence of MetS were 22.6, 32.9, 42.9, and 57.5 per 1,000 person-years of follow-up in the 1st, 2nd, 3rd, and 4th quartiles of WBC, respectively. After adjustments for confounding factors, the adjusted hazards ratio (95% confidence interval) for MetS was 1.00 (reference), 1.22 (0.98 to 1.51), 1.52 (1.24 to 1.87), and 1.66 (1.35 to 2.04) through the quartiles of WBC, respectively, (p <0.001). This relationship was consistent among current smokers and never smokers, and among male and female genders, respectively. Conclusion WBC is useful in predicting the future development of MetS which leads to atherosclerotic diseases.

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Comparison between High-Sensitivity C-Reactive Protein (hs-CRP) and White Blood Cell Count (WBC) as an Inflammatory Component of Metabolic Syndrome in Japanese

Abstract: Objective To compare two systemic inflammatory markers, high-sensitivity C-reactive protein (hs-CRP) and white blood cell count (WBC), as a component of metabolic syndrome (MetS

Cited by 62 publications

References 50 publications

Reproducibility of High-Sensitivity C-Reactive Protein as an Inflammatory Component of Metabolic Syndrome in Japanese

Reproducibility of High-Sensitivity C-Reactive Protein as an Inflammatory Component of Metabolic Syndrome in Japanese

Association between the neutrophil to lymphocyte ratio and prehypertension

Longitudinal Study on White Blood Cell Count and the Incidence of Metabolic Syndrome

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