Comparison between Histological Features and Strain Elastographic Characteristics in Canine Mammary Carcinomas

Pastor, Nieves; Espadas, Lorena; Santella, Massimo; Ezquerra, Luis Javier; Tarazona, Raquel; Durán, ME

doi:10.3390/vetsci9010009

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Although most of the studies conducted in CMTs are based on the latter classification, in 2019, a new histopathological classification for CMTs was published by the Davis-Thompson Foundation [47]. Since then, some studies have used this novel classification to categorize the neoplastic lesions in canine mammary glands [173][174][175][176][177][178][179]. This new classification classifies epithelial neoplastic lesions as either benign or malignant, which are further subdivided into simple, non-simple and ductal-associated tumors.…”

Section: Histological and Molecular Classification Of Breast/mammary ...mentioning

confidence: 99%

Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research

Ferreira

Gama

Seixas

et al. 2023

Veterinary Sciences

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Breast cancer is one of the most common and well-known types of cancer among women worldwide and is the most frequent neoplasm in intact female dogs. Female dogs are considered attractive models or studying spontaneous breast cancer, whereas female rats are currently the most widely used animal models for breast cancer research in the laboratory context. Both female dogs and female rats have contributed to the advancement of scientific knowledge in this field, and, in a “One Health” approach, they have allowed broad understanding of specific biopathological pathways, influence of environmental factors and screening/discovery of candidate therapies. This review aims to clearly showcase the similarities and differences among woman, female dog and female rat concerning to anatomical, physiological and histological features of the mammary gland and breast/mammary cancer epidemiology, in order to better portray breast tumorigenesis, and to ensure appropriate conclusions and extrapolation of results among species. We also discuss the major aspects that stand out in these species. The mammary glands of female dogs and women share structural similarities, especially with respect to the lactiferous ducts and lymphatic drainage. In contrast, female rats have only one lactiferous duct per nipple. A comprehensive comparison between humans and dogs is given a special focus, as these species share several aspects in terms of breast/mammary cancer epidemiology, such as age of onset, hormonal etiology, risk factors, and the clinical course of the disease. Holistically, it is clear that each species has advantages and limitations that researchers must consider during the development of experimental designs and data analysis.

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Section: Histological and Molecular Classification Of Breast/mammary ...mentioning

confidence: 99%

Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research

Ferreira

Gama

Seixas

et al. 2023

Veterinary Sciences

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show abstract

“…In general, elastography can be used to differentiate affected tissue (with morphostructural alterations) from normal tissue [ 21 ]. This technique has been explored for several clinical purposes and introduced into medical diagnostic routines for specific uses, such as the evaluation of liver transplantation in humans [ 22 ], splenic alterations [ 20 ], and characterization of mammary lesions in dogs [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

B-mode ultrasonography and ARFI elastography of articular and peri-articular structures of the hip joint in non-dysplastic and dysplastic dogs as confirmed by radiographic examination

Carneiro,

da Cruz,

Gasser

et al. 2023

BMC Vet Res

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Background Canine hip dysplasia is a common orthopedic disease in veterinary practice. The diagnosis is made by radiographic examinations that evaluate bone alterations associated with hip dysplasia. Although radiographic examination is the gold standard for diagnosis, it does not allow a detailed evaluation of soft tissues such as the joint capsule and periarticular muscles. This study aimed to evaluate the accuracy of B-mode ultrasonography and acoustic radiation force impulse (ARFI) elastography in assessing the joint capsule and periarticular muscles of dogs using the Orthopedic Foundation of Animals (OFA) classification and the distraction index (DI) in the early and late diagnosis of hip dysplasia. This study sought to propose a protocol for the ultrasonographic evaluation of the structures involved in canine hip dysplasia. Methods Radiographic and ultrasonographic evaluations were performed on 108 hip joints of 54 dogs. Thirty dogs were older than 2 years and 24 were aged between 4 and 10 months. Results It was verified that an increase in pectineus muscle stiffness (cutoff value > 2.77 m/s) by elastography in some dysplastic dogs and an increase in the thickness of the joint capsule (cutoff value > 0.9 mm) in B-mode ultrasonography, were associated with a distraction index > 0.5, with both having a positive correlation. In B-mode ultrasonographic evaluation, the presence of signs of degenerative joint disease, such as irregularities of the cranial edge of the acetabulum and femoral head, were associated with a distraction index > 0.5 in canines, with a specificity of 94%. In adult dogs, the findings of degenerative joint disease on ultrasound were associated with a diseased OFA classification (P < 0.05). Measurement of the joint capsule > 1.10 mm was diagnostic for dysplasia in unhealthy dogs by OFA. Conclusions ARFI elastography has shown that the pectineus muscle may experience changes in stiffness in dysplastic animals. Additionally, changes in joint capsule thickness can be identified in B-mode in young and adult dogs with dysplastic joints, which contributes to the diagnosis of hip dysplasia.

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“…In general, elastography can be used to differentiate affected tissue (with morphostructural alterations) from normal tissue [21]. This technique has been explored for several clinical purposes and introduced into medical diagnostic routines for speci c uses, such as the evaluation of liver transplantation in humans [22], splenic alterations [20], and characterization of mammary lesions in dogs [23,24].…”

Section: Introductionmentioning

confidence: 99%

Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

Carneiro

Cruz

Gasser

et al. 2022

Preprint

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Background: Canine hip dysplasia is common orthopedic disease in veterinary, characterized by hip instability in puppies and secondary degenerative joint disease in adult. Radiographic examination has been the main diagnostic method of hip dysplasia. Different radiographic studies, in addition to diagnosing joint laxity and degenerative joint disease, facilitate patient screening and selection of optimal treatment. However, radiographs do not allow for the assessment of capsular characteristics and adjacent muscles, which can be thoroughly evaluated using various ultrasound techniques. Radiographic examinations require anesthetic management, often causing discomfort in the patients and an inconvenience to owners. This study aimed to evaluate the accuracy of B-mode ultrasonography and acoustic radiation force impulse elastography in the evaluation of the joint capsule and periarticular musculature of dogs using the classification of the Orthopedic Foundation of Animals (OFA) and the distraction index (DI) in the early and late diagnosis of hip dysplasia. This study sought to propose a protocol for the ultrasonographic evaluation of the structures involved in canine hip movement. Results: Radiographic and ultrasonographic evaluations were performed on 108 hip joints of 54 dogs. Thirty dogs were older than 2 years and 24 were aged between 4 and 10 months. It was verified that an increase in pectineus muscle stiffness (cutoff value >2.77 m/s) by elastography and an increase in the thickness of the joint capsule (cutoff value >0.9 mm) in B-mode ultrasonography, were associated with a distraction index >0.5, with both having a positive correlation. In B-mode ultrasonographic evaluation, the presence of signs of degenerative joint disease, such as irregularities of the cranial edge of the acetabulum and femoral head, were associated with a distraction index >0.5 in canines, with a specificity of 94%. In adult dogs, the findings of degenerative joint disease on ultrasound were associated with a diseased OFA classification (P<0.05). Measurement of the joint capsule >1.10 mm was diagnostic for dysplasia in unhealthy dogs by OFA. Conclusions: Ultrasound can be used as an adjuvant diagnostic modality in the diagnosis of hip dysplasia in association with radiographic evaluation in young and adult animals.

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Comparison between Histological Features and Strain Elastographic Characteristics in Canine Mammary Carcinomas

Cited by 4 publications

References 38 publications

Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research

Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research

B-mode ultrasonography and ARFI elastography of articular and peri-articular structures of the hip joint in non-dysplastic and dysplastic dogs as confirmed by radiographic examination

Accuracy of B-mode ultrasonography and ARFI elastography in the evaluation of the hip joint and hip musculature for the early and late diagnosis of hip dysplasia in dogs

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