Comparison Between Intramuscular and Perimuscular Injections of Botulinum Toxin Type A

Campos, José Humberto Oliveira; Oliveira, Lise B.; Queiroz, Taise O.; Santos, Kleber Pimentel; Freitas, Francesca M.

doi:10.1007/s00266-005-0221-y

Cited by 5 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 Based on the ability of causing partial and reversible muscle paralysis, it is clinically used for treatment of muscle over activity and many other disorders including achalasia, hyperhydrosis, chronic anal fissure, and spasticity. 21 BXTA not only increases the shrinkage of muscle morphologically, but also results in loss of contraction force in a dose-dependent manner. 20,21 In our study, the weight of the quadriceps showed no significant difference in the BXTA side from 1 to 8 weeks after BXTA injection.…”

mentioning

confidence: 99%

“…21 BXTA not only increases the shrinkage of muscle morphologically, but also results in loss of contraction force in a dose-dependent manner. 20,21 In our study, the weight of the quadriceps showed no significant difference in the BXTA side from 1 to 8 weeks after BXTA injection. Meanwhile, the weight of muscle injected with BXTA was significant lower than that of muscle injected with saline in opposite side.…”

mentioning

confidence: 99%

“…Intramuscular injection of BXTA also results in local paresis and atrophy of targeted muscles. 21 This clinical effect of BXTA lasts for 3-6 months in humans, after which the injected muscle regains muscle mass and strength. In rodents, the recovery of muscle function is achieved at a much more rapid rate.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Short‐term muscle atrophy caused by botulinum toxin‐A local injection impairs fracture healing in the rat femur

Hao

Wang

et al. 2011

Journal Orthopaedic Research

View full text Add to dashboard Cite

Damaged bone is sensitive to mechanical stimulation throughout the remodeling phase of bone healing. Muscle damage and muscular atrophy associated with open fractures and subsequent fixation are not beneficial to maintaining optimum conditions for mechanical stability. The aim of this study was to investigate whether local muscle atrophy and dysfunction affect fracture healing in a rat femur fracture model. We combined the rat model of a short period atrophy of the quadriceps with femur fracture. Forty-fourmonth-old male Wistar rats were adopted for this study. Two units of botulinum toxin-A (BXTA) were administered locally into the right side of the quadriceps of each rat, while the same dose of saline was injected into the contralateral quadriceps. After BXTA had been fully absorbed by the quadriceps, osteotomy was performed in both femurs with intramedullary fixation. Gross observation and weighing of muscle tissue, X-ray analysis, callus histology, and bone biomechanical testing were performed at different time points up to 8 weeks post-surgery. Local injection of BXTA led to a significant decrease in the volume and weight of the quadriceps compared to the control side. At the eighth week, the left side femurs of the saline-injected quadriceps almost reached bony union, and fibrous calluses were completely calcified into woven bone. However, a gap was still visible in the BXTA-treated side on X-ray images. As showed by bone histology, there were no mature osseous calluses or woven bone on the BXTA-treated side, but a resorption pattern was evident. Biomechanical testing indicated that the femurs of the BXTA-treated side exhibited inferior mechanical properties compared with the control side. The inferior outcome following BXTA injection, compared with saline injection, in terms of callus resistance may be the consequence of unexpected load and mechanical unsteadiness caused by muscle atrophy and dysfunction. ß

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Short‐term muscle atrophy caused by botulinum toxin‐A local injection impairs fracture healing in the rat femur

Hao

Wang

et al. 2011

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…However, it is well known that an effect can be obtained by injection near rather than in the target area. 13,14 Botulinum toxin injection may restore fusion and prevent medial rectus muscle contracture in the acute phase of abducens nerve palsy. [1][2][3][4][5][6] Its use in this setting is, however, controversial.…”

Section: Discussionmentioning

confidence: 99%

Botulinum toxin injection with and without electromyographic assistance for treatment of abducens nerve palsy: A pilot study

Sanjari

Falavarjani

Kashkouli

et al. 2008

Journal of American Association for Pediatric Ophthalmology and

View full text Add to dashboard Cite

Systematic review of the histological and functional effects of botulinum toxin A on masticatory muscles: Consideration in dentofacial orthopedics and orthognathic surgery

Guignardat,

Raoul,

Ferri

et al. 2024

Annals of Anatomy - Anatomischer Anzeiger

View full text Add to dashboard Cite

Comparison Between Intramuscular and Perimuscular Injections of Botulinum Toxin Type A

Abstract: No significant difference in the neuromuscular blockade induced by botulinum toxin type A was observed between injections into the muscle peripheral area and intramuscular injections.

Cited by 5 publications

References 8 publications

Short‐term muscle atrophy caused by botulinum toxin‐A local injection impairs fracture healing in the rat femur

Short‐term muscle atrophy caused by botulinum toxin‐A local injection impairs fracture healing in the rat femur

Botulinum toxin injection with and without electromyographic assistance for treatment of abducens nerve palsy: A pilot study

Systematic review of the histological and functional effects of botulinum toxin A on masticatory muscles: Consideration in dentofacial orthopedics and orthognathic surgery

Contact Info

Product

Resources

About