Nanofluids consist of liquid and solid (nanoparticles), therefore, they can be classified as two-component flow, which brings up different approaches for simulation purposes. In this study, heat transfer and hydro-dynamic features of nanoparticles in a laminar nanofluid flow in a vertical tube are investigated numerically via Lagrangian and Eulerian approaches.Discrete Phase Model (DPM) in Lagrangian approach simulates the motion of particles through base flow with force balance equation, therefore, no needs empirical correlations at least for the thermo-physical properties (which they are not universal and change for different fluids and/or nanoparticles). Although, general empirical or analytical correlations are needed for some interactions between solid and liquid such as Thermophoresis, Brownian and clustering effects, but they are not that extensive and can be employed in most of the cases.Mixture model in Eulerian approach provides more reliable results, but it highly depends on the accuracy of the correlations for the thermo-physical properties of the nanofluid. In present study, three common types of nanofluids consist of Alumina, Zirconia and Silica nanoparticles (up to 2.76% of volume fraction) are studied and the results are compared with experimental works. Numerical simulations indicate that the findings are in good agreement with the measured heat transfer coefficient for DPM. Consequently, DPM can be highly recommended for simulation study due to the strength and simplicity. It has been also observed that the effects of nanoparticles in each computational cell need to be distributed to the other neighbourhood cells. Pressure losses results predicted by DPM were found reliable for volume fraction less than 3%, no matter the types of nanoparticles or diameter. DPM velocity profiles show that the slip velocity between nanoparticles and base flow is not negligible.