Comparison between left atrial features in well-controlled hypertensive patients and normal subjects assessed by three-dimensional speckle tracking echocardiography

Onishi, Noriyuki; Kawasaki, Masanori; Tanaka, Ryuhei; Sato, Hidemaro; Saeki, Makio; Nagaya, Maki; Sato, Noriaki; Minatoguchi, Shingo; Watanabe, Takatomo; Ono, Katsushige; Arai, M.; Noda, Toshiyuki; Amano, Kazuo; Goto, Kazuko; Watanabe, Soichi; Minatoguchi, Shinya

doi:10.1016/j.jjcc.2013.09.006

Cited by 15 publications

(8 citation statements)

References 28 publications

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“…However, another Chinese cross-sectional study reported that these three function of LA all impaired in HT group [33] . Disparities among these reports may be result from different grade of HT, age, duration of HT, grade of HT, medication and the control of blood pressure [34][35] .…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Phasic Function Remodeling During Its Enlargement: a Two-dimensional Speckle-tracking Echocardiography Study

Chen

Yang

Zhang

2021

Preprint

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Background: Left atrial (LA) size is often used as a surrogate marker of LA function in clinical practice, with larger atria thought to represent a “dysfunctioning” atrium, since there is no accepted ‘gold’ standard to evaluate LA function. The exact relationship between LA size and phasic function, and whether LA dysfunction occur before LA enlargement (LAE) may be of clinical interest while have not been fully studied. Two-dimensional speckle-tracking echocardiography (2D STE) was showed a promising method in measuring LA physic deformation. Materials and methods: A community cohort of 715 subjects at cardiovascular disease high risk accepted comprehensive echocardiography. LA longitudinal phasic strain Sa (absolute peak strain during atrial contraction), Se (peak strain at early diastole) and Stot (total atrial strain =Sa+Se), representing contractile, conduit, and reservoir function respectively, were measured using off-line 2D STE software in apical 4 chamber view, and data were compared among groups at different LA size and between sub-groups in normal LA size with and without hypertension (HT). Results: With LAE (from normal size, mild, moderate to severe LAE), the Stot(21.74±5.97,20.75±4.99,20.49±5.27,17.75±4.71, respectively, ANOVA p=0.003) and Sa (11.84±3.92,11.00±3.29,10.11±2.57,8.55±2.88, respectively, ANOVA p<0.001) reduced while Se had no change. In normal sized LA subgroups, Stot (21.35±5.91 vs 23.01±6.02, p=0.008) and Se (9.51±4.41 vs 11.17±4.89, p<0.001) reduced in subjects with HT comparing with those without. Conclusion: LA phasic function remodeling occurs before LAE and continues with LAE, with reservoir, conduit and contractile function being affected unparalleled.

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Section: Discussionmentioning

confidence: 99%

Left Atrial Phasic Function Remodeling During Its Enlargement: a Two-dimensional Speckle-tracking Echocardiography Study

Chen

Yang

Zhang

2021

Preprint

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“…LA enlargement and dysfunction are frequently seen in patients with PAF and HT, thus increasing cardiovascular risk and becoming indexes of future cardiovascular events 32,33 . Several studies investigate LA function in terms of shape parameters or 2D strain, but often they evaluated this in a single moment of the entire atrial cycle; moreover, they considered only control subjects versus AF patients 20 .…”

Section: Discussionmentioning

confidence: 99%

Improving performance of 3D speckle tracking in arterial hypertension and paroxysmal atrial fibrillation by using novel strain parameters

Esposito

Piras

Evangelista

et al. 2019

Sci Rep

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The function of left atrium (LA) is closely related to LA remodeling and one of the most important mechanisms is an increased deposition of fibrous tissue that often is the basis for LA electro-mechanical changes before the onset of atrial fibrillation (AF). This study evaluated LA shape and function, by investigating standard and novel strain parameters calculated by a new approach based on homologous times derived from 3D speckle tracking echocardiography (3DSTE) in hypertensive (HT) and paroxysmal atrial fibrillation (PAF) patients with or without left ventricular hypertrophy (LVH), compared to control (C) subjects. LA function was assessed using homologous times to compare strain variables among different individuals, acquired at different physiological time periods. Standard global longitudinal (GLS) and circumferential (GCS) strains were measured at peak of atrial diastole, while longitudinal and circumferential strains (GLSh, GCSh), strain rate (GLSr, GCSr), volume (Vh) and volume rate (Vr) were measured during the atrial telediastolic phase (fifth homologous time) and atrial pre-active phase (tenth homologous time). Using ANOVA, we found an impaired LA deformation detected by standard, interpolated strains and strain rates in both HT and PAF groups compared to C. We also performed ROC analysis to identify different performances of each parameter to discriminate groups (GLSr10 + GCSr10: C vs PAF 0.935; C vs PAF_LVH 0.924; C vs HT_LVH 0.844; C vs HT 0.756). Our study showed anatomical and functional LA remodeling in patients with PAF and HT. 3D strains and strain rates derived from the homologous times approach provide more functional information with improved performance to identify among the explored groups, in particular PAF patients.

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“…Recent advances in echocardiographic imaging and mainly the advent of two-dimensional speckle tracking echocardiography (2D-STE) myocardial strain assessment enabled a more independent insight into atrial function by visualising and calculating each of the phases separately [ 4 ]. Alterations in 2D-STE-derived atrial strain assessment have already been described in patients with systemic arterial hypertension [ 5 , 6 ], atrial fibrillation [ 7 ] and diastolic heart failure [ 8 ]. Indeed, this non-invasive tool holds promise for detecting even subclinical stages of atrial dysfunction [ 9 ] which would enable initiation of therapy before irreversible atrial damage occurs and thereby has important clinical implications for the evaluation and management of patients with various cardiac diseases.…”

Section: Introductionmentioning

confidence: 99%

Reliability of echocardiographic speckle-tracking derived bi-atrial strain assessment under different hemodynamic conditions

Sareban

Perz

Macholz

et al. 2017

Int J Cardiovasc Imaging

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The aim of this study was to assess intra- and inter-observer variability of left (LA) and right atrial (RA) strain indices obtained by two-dimensional speckle-tracking echocardiography (2D-STE) in a healthy group of individuals at low-altitude and after rapid ascent to high-altitude in order to provoke altered systemic and pulmonary hemodynamics otherwise seen in various cardiac diseases. Twenty healthy subjects underwent transthoracic echocardiography during a baseline examination at low-altitude (424 m) as well as 7, 20 and 44 h after arrival at high-altitude (4559 m). Atrial strain indices (i.e. reservoir, conduit and contractile strain) were determined off-line by two independent observers. Intra- and inter-observer reproducibility of variables was assessed by intra-class correlation coefficients (ICCs), coefficients of variation and Bland Altman plots. Heart rate, systemic blood pressure and pulmonary artery pressure increased significantly from low-altitude to the first examination at high-altitude. Intra-observer ICCs were ≥0.90 except for RA conduit strain with an ICC of 0.86. The mean intra-observer differences were small and limits of agreement of relative differences were narrow for all atrial strain parameters (<3 and <16%, respectively). Inter-observer ICCs (0.80–0.90), mean biases and limits of agreement (<4 and <20%, respectively) were greater than intra-observer results for all parameters. Intra- and inter-obserer ICCs for all atrial strain variables did not differ between low- and high-altitude. 2D-STE-derived bi-atrial strain indices have excellent intra- and moderate inter-observer reproducibility with no effect of high-altitude-induced hemodynamic changes on reliability results.

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Comparison between left atrial features in well-controlled hypertensive patients and normal subjects assessed by three-dimensional speckle tracking echocardiography

Abstract: These results suggest that LV diastolic dysfunction occurs before structural changes of left atrium and left ventricle even in patients with well-controlled HTN.

Cited by 15 publications

References 28 publications

Left Atrial Phasic Function Remodeling During Its Enlargement: a Two-dimensional Speckle-tracking Echocardiography Study

Left Atrial Phasic Function Remodeling During Its Enlargement: a Two-dimensional Speckle-tracking Echocardiography Study

Improving performance of 3D speckle tracking in arterial hypertension and paroxysmal atrial fibrillation by using novel strain parameters

Reliability of echocardiographic speckle-tracking derived bi-atrial strain assessment under different hemodynamic conditions

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