Comparison between magnesium sulfate (50 mg/kg) and lignocaine (2 mg/kg) for attenuation of intubation response in hypertensive patients

Bhalerao, Nikhil; Modak, Anjali; Belekar, Virendra

doi:10.4103/jdmimsu.jdmimsu_58_17

Cited by 7 publications

(5 citation statements)

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“…Majority of patients belonging to the age group of 20-30 years. The mean (±SD) weight (in kg) of 20 compared the effect of magnesium sulfate and lignocaine in attenuating intubation response in hypertensive patients. They found that HR tends to decrease after induction with a brief increase after intubation in both the groups and but the difference was not statistically significant between the groups throughout the study period (P>0.05).…”

Section: Discussionmentioning

confidence: 99%

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Kothari¹,

Bansal²,

Sunny³

2022

Asian J Med Sci

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Background: Hemodynamic alterations during general anesthesia with endotracheal intubation are due to stimulation of the sympathetic nervous system and catecholamine release. Therefore, it is important to attenuate these responses in pre-eclampsia patients who are already under stress. Aims and Objectives: The present study aimed to evaluate the combined efficacy of paracetamol, magnesium sulfate, and lignocaine in attenuating hemodynamic responses during intubation and perioperative period. Materials and Methods: Eighty ASA II pre-eclampsia patients were randomly divided into two groups. Group PLM received intravenous infusion of paracetamol (1 g) and magnesium sulfate (30 mg/kg) in 100 ml normal saline and IV bolus Inj. lignocaine (1.5 mg/kg) 15 min before induction. Group C received only IV infusion of 100 ml normal saline. Pulse rate (PR), blood pressure (BP), and oxygen saturation were measured at various time intervals up to 40 min of delivery of baby and in up to 240 min in post-operative period. Post-operative visual analog score (VAS) and the time for first rescue analgesia (TRA I) were recorded. Results: Demographic and baseline hemodynamic parameters were comparable in both groups (P>0.05). Changes in PR and BP during laryngoscopy, intubation, and perioperative period were significantly lesser in Group PLM as compared to Group C (P<0.05). The post-operative VAS score was significantly lower whereas TRA I was significantly longer in Group PLM than in Group C at all measuring times (P<0.05). Conclusion: Combination of paracetamol, magnesium sulfate, and lignocaine attenuates hemodynamic responses during laryngoscopy, intubation, and perioperative period along with prolonged post-operative analgesia in cesarean section under general anesthesia in pre-eclampsia patients.

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Section: Discussionmentioning

confidence: 99%

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Kothari¹,

Bansal²,

Sunny³

2022

Asian J Med Sci

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“…Laparoscopic surgeries have revolutionized general surgeries and have now become the gold standard for treatment of cholelithiasis. Laparoscopy surgery is also helpful in the staging and diagnosis of abdominal malignancy (Yeola et al, 2018(Yeola et al, , 2019.Laparoscopic surgery has its own complications like signi icant hemodynamic changes observed during pneumoperitoneum, including a rise in heart rate, blood pressure, and an increase in systemic vascular resistance with a resultant fall in cardiac output (Guyton, 1991;Joris et al, 1993).Different techniques and pharmacological agents have been used to obtund this response like Magnesium sulphate, dexmedetomidine, esmolol etc (Bhalerao et al, 2017;Sen et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Pregabalin As A Premedicant To Attenuate Pressor Response In Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Agrawal¹,

Bhagat²,

Deshmukh³

et al. 2020

ijrps

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The present study was done to evaluate the ability of oral pregabalin to attenuate the pressor response to airway instrumentation in patients undergoing laparoscopic cholecystectomy under general anesthesia. Sixty-four adult patients aged between 25-55 year of either gender belonging to ASA-1 or ASA2 physical status weighing 50-70 kg were enrolled in this study. Thirty-two patients each were randomized to group A, or group B. Patients in group A received tablet Pregabalin (150mg) and those in group B received placebo orally one hour before induction of anaesthesia. Heart rate, blood pressure, and sedation were assessed preoperatively before giving the tablets and after 30 minutes, and just before induction of anaesthesia. Intraoperative, pulse rate, mean arterial pressure, ECG in the lead II, SPO2 and ETCO2 were monitored. All the above parameters were noted during laryngoscopy and intubation, 3 minutes after CO2 insufflation, and then at every 10-minute interval till the end of surgery. These parameters were also recorded after extubating the patient. The Ramsay sedation scale was used to assess the sedation at the baseline, one hour after drug intake , one hour after extubation and 4 hour after surgery. Any adverse effects in the postoperative period were recorded. The result of our study shows that pre-emptive administration of oral pregabalin 150 mg significantly reduced the pressor response at the time of laryngoscopy and intubation, after CO2 insufflation and just after extubation. We conclude that oral pregabalin premedication is effective in successful attenuation of hemodynamic pressor response to laryngoscopy, intubation and pneumoperitoneum in patients undergoing laparoscopic cholecystectomy

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“…In cases with apparently difficult intubation, the study concludes that the Airtraq laryngoscope has a benefit over the Macintosh laryngoscope, in addition to promoting intubation in patients with minimal head extension due to its clearer view of the oropharyngeal and glottic regions [10]. Few of the related studies on endotracheal intubation were reviewed [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Macintosh and Airtraq Laryngoscopes for Laryngeal View during Endotracheal Intubation: A Study Protocol

Bhardwaj

Singam

2021

JPRI

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Background: Intubating trachea is a routine procedure for anaesthesiologists, but during surgeries, protecting the airway remains a challenge. Intubation failure in anaesthetic and emergency cases remains a big cause of mortality and morbidity. The Macintosh laryngoscope remains most widely used of various inventions and numerous advancements in the airway used for endotracheal intubation. Airtraq laryngoscope is a novel video laryngoscope which aids the procedure for intubation of patients with difficult or normal airways. Airtraq blade curvature and the precise internal arrangement of the optical components are made in such a way that enables visualization of the glottic field with minimal manipulation of the pharyngeal, oral and tracheal axis. This study aims to compare Airtraq and Macintosh Laryngoscope for Laryngeal view. Methods: This will be a prospective comparative randomised study that will include total 80 patients. Patients posted for surgery under general anaesthesia will be randomized into two groups (i.e. 40 in each groups): Group M-E patients will be intubated with Macintosh Endotracheal Intubation whereas Group A-E patients will be intubated with Airtraq Endotracheal Intubation. Patients will be evaluated for Ease of intubation, duration of induction, successful number of attempts and hemodynamic parameters. Data will be compiled and analysed with appropriate statistical programme. Expected Results: Significant results are expected to support that, Airtraq can be secured easily and with lesser number of attempts compared to Macintosh and duration of insertion is less. Conclusion: Intubation with Airtraq is easier in relation to intubation ease and duration compared to Macintosh with less post-operative complications.

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Comparison between magnesium sulfate (50 mg/kg) and lignocaine (2 mg/kg) for attenuation of intubation response in hypertensive patients

Cited by 7 publications

References 0 publications

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Effect of pre-emptive intravenous paracetamol, magnesium sulfate, and lignocaine on hemodynamic variables during perioperative period in pre-eclampsia patients scheduled for lower segment cesarean section under general anesthesia: A prospective randomized study

Pregabalin As A Premedicant To Attenuate Pressor Response In Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Comparative Evaluation of Macintosh and Airtraq Laryngoscopes for Laryngeal View during Endotracheal Intubation: A Study Protocol

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