Aim: The purpose of this study was to make a comparison between measured and calculated physical wedge dose distributions using the superposition algorithm. Settings and Design: The accurate determination of absorbed dose is important radiotherapy because of the relatively steep sigmoidal dose response curves for both tumor control and normal-tissue damage. Materials and Methods: High-energy photons (6 and 10 MV) from Artiste Treatment System Linear Accelerator Machine, available at Alexandria Ayadi Al-Mostakbal Oncology Center, were used. Results and Discussion: The results showed that the difference between measured and calculated wedged isodose curves depends on field size, beam energy, and the angle of the used wedge. Conclusion: The results showed that the presence of a wedge alters the primary and scattered components generated by a linear accelerator and causes beam hardening in 6 and 10 MV. The beam hardening increased as the wedge angle increased.