Comparison between oral and dermal bioavailability of soil-adsorbed phenanthrene in female rats

Kadry, Abdelrazak M.; Skowronski, Gloria A.; Turkall, Rita M.; Abdel‐Rahman, Mohamed S.

doi:10.1016/0378-4274(95)03250-o

Cited by 32 publications

(32 citation statements)

References 16 publications

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“…Unlike the Turkall et al(1994) and Kadry (1995) studies, the sandy soil with higher organic matter had higher dermal bioavailability. This is probably due to the autoclaving step used in soil preparation which may have broken down the organic matter in the soil.…”

Section: Key In Vitro Dermal Bioavailability Studiesmentioning

confidence: 56%

“…Alexander (2000). Most of the studies reviewed do not use naturally aged soil, but rather spike natural soil or amended soil (Yang et al, 1989;Wester et al, 1990;Turkall et al,, 1994;Kadry et al, 1995;Roy et al,, 1998b;Roy and Singh, 2001;Abdel-Rahman et al, 2002;Moody et al, 2007). Part of the reason for this is coupled with using radiolabelled PAH and associated scintillation methods for quantification (Table 1).…”

Section: Soil Maturitymentioning

confidence: 99%

“…The in vivo animal studies which relate specifically to PAH dermal bioavailability from soils have used monkeys, rats and guinea pigs (Yang et al, 1989;Wester et al, 1990;Turkall et al, 1994;Kadry et al, 1995;Moody et al, 1995;Roy et al, 1998a). These tests take the general form of applying the test chemical to a designated area of skin in an appropriate vehicle (for the purposes of this review this is soil).…”

Section: Animal Exposurementioning

confidence: 99%

“…Again, it is unclear if the dermal bioavailability includes the amount of BaP in the skin as well as in the receptor fluid. Turkall et al, (1994) and Kadry (1995). The same soils (a sandy soil: 90% sand, 2% clay, 4.4% organic matter; a clay soil: 50% sand, 22% clay, 1.6% organic matter) were autoclaved and deionised water added to achieve a moisture content of 11%.…”

Section: Key In Vitro Dermal Bioavailability Studiesmentioning

confidence: 99%

“…Phenanthrene: Kadry et al, (1995); USEPA 16: Moody et al, (2011); 60 PAH: Roy et al, (1998)). Roy et al (1998) measured the dermal bioavailability of 60 PAH using a Franz diffusion cell with rat skin and a Volpo 20 TM receptor solution with a 0.01% thimersol antibacterial agent over a 24 h period.…”

Section: Percentage Absorbed Of Applied Dose and Experimental Conditionsmentioning

confidence: 99%

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A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

Beriro

Cave

Wragg

et al. 2016

Journal of Hazardous Materials

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Polycyclic Aromatic Hydrocarbons are classed as Persistent Organic Pollutants, a large group of compounds that share similar characteristics. They are lipophilic, resistant to degradation in the environment and harmful to human and environmental health. Soil has been identified as the primary reservoir for Polycyclic Aromatic Hydrocarbons in the United Kingdom. This study reviews the literature associated with, or is relevant to, the measurement and modelling of dermal absorption of Polycyclic Aromatic Hydrocarbons from soils. The literature illustrates the use of in vivo, in vitro and in silico methods from a wide variety of scientific disciplines including occupational and environmental exposure, medical, pharmaceutical and cosmetic research and associated mathematical modelling. The review identifies a number of practical shortcomings which must be addressed if they are to be applied to high throughput laboratory analysis of contaminated soils for human health risk assessment.

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Section: Key In Vitro Dermal Bioavailability Studiesmentioning

confidence: 56%

Section: Soil Maturitymentioning

confidence: 99%

Section: Animal Exposurementioning

confidence: 99%

Section: Key In Vitro Dermal Bioavailability Studiesmentioning

confidence: 99%

Section: Percentage Absorbed Of Applied Dose and Experimental Conditionsmentioning

confidence: 99%

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A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

Beriro

Cave

Wragg

et al. 2016

Journal of Hazardous Materials

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Is received dose from ingested soil independent of soil PAH concentrations?—Animal model results

Peters

James

Cave

et al. 2016

Enviro Toxic and Chemistry

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19Human exposure to polycyclic aromatic hydrocarbons (PAHs) often occurs through the oral 20 route during hand to mouth transfer of contaminated soils. It is accepted that PAH bioavailability 21 from ingested soils will vary between soils, however, the nature of this variation is not well 22 characterized. Here, we used the juvenile swine model to link external exposure to internal 23 benzo influencing internal exposure of PAHs. We propose four PAH risk assessment options: (i) 34 assume 100% bioavailability, (ii) assume constant internal exposure below 1,900 mg kg -1 , (iii) 35 assume <100%, e.g. 21%, bioavailability below 1,900 mg kg -1 , or (iv) model internal exposure 36 through AUC versus soil characteristic relationships. In our opinion, our data best supports 37 option (ii) because we could not detect an increase in AUC with increasing soil concentrations 38 and our best efforts at (iv) do not robustly predict uptake of different PAHs. 39

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Assessment of the Bioavailability of PAHs in Rats Exposed to a Polluted Soil by Natural Routes: Induction of EROD Activity and DNA Adducts and PAH Burden in Both Liver and Lung

Fouchécourt¹,

Arnold²,

Berny

et al. 1999

Environmental Research

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Comparison between oral and dermal bioavailability of soil-adsorbed phenanthrene in female rats

Cited by 32 publications

References 16 publications

A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

Is received dose from ingested soil independent of soil PAH concentrations?—Animal model results

Assessment of the Bioavailability of PAHs in Rats Exposed to a Polluted Soil by Natural Routes: Induction of EROD Activity and DNA Adducts and PAH Burden in Both Liver and Lung

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