Comparison between paediatric risk of mortality III and paediatric logistic organ dysfunction-2 as mortality predictor in paediatric intensive care

Shenoy, Sangeetha; Patil, Shruti; Karunakar, B. P.; Mangalgi, Sharanabasavesh; Samaga, Vishal

doi:10.4038/sljch.v52i1.10473

Cited by 2 publications

(1 citation statement)

References 16 publications

(31 reference statements)

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“…PELOD-2 and PRISM-III were considered to be elevated if the values were more than 7.5 and 9.5, respectively, which were the cutoffs derived from a previous study. 13…”

Section: Methodsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio as Predictors of Disease Severity and Mortality in Critically Ill Children: A Retrospective Cohort Study

Shenoy

Patil

2023

J Pediatr Intensive Care

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The aim of this study was to determine the ability of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) to predict the severity of illness as assessed by two scoring systems, namely, Pediatric Logistic Organ Dysfunction-2 (PELOD-2) and Pediatric Risk of Mortality-III (PRISM-III) and outcome. This was a retrospective cohort study wherein all critically ill children aged 1 month to 18 years admitted in the pediatric intensive care unit from January 2021 to October 2022 were included. Children with chronic systemic diseases and hematological illness were excluded from the study. Demographic details, diagnosis, PRISM-III-24 and PELOD-2 scores at admission, and outcome were retrieved from the hospital case records. NLR and PLR values were compared among high and normal PRISM-III and PELOD-2 groups as well as among survivors and nonsurvivors. A total of 325 patients with critical illness were included with a mean (standard deviation) age of 7(5) years and a male: female ratio of 3:2. The values of NLR were significantly higher among the patients with high PRISM-III (2.2 vs. 1.3, p-value = 0.006) and PELOD-2 (2 vs. 1.4, p-value = 0.015) groups compared with normal. The NLR and PLR were significantly higher among the nonsurvivors compared with the survivors (2.3 vs. 1.4, p-value = 0.013, and 59.4 vs. 27.3, p-value = 0.016 for NLR and PLR, respectively). The area under the receiver operating characteristics curve for NLR and PLR was 0.617 and 0.609, respectively. A high PLR, PRISM-III, and PELOD-2 were the factors found to be independently associated with mortality on multiple logistic regression analysis. Patients with high NLR are associated with more severe illness at admission. NLR and PLR are useful parameters to predict mortality.

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“…PELOD-2 and PRISM-III were considered to be elevated if the values were more than 7.5 and 9.5, respectively, which were the cutoffs derived from a previous study. 13…”

Section: Methodsmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio as Predictors of Disease Severity and Mortality in Critically Ill Children: A Retrospective Cohort Study

Shenoy

Patil

2023

J Pediatr Intensive Care

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Severity of organ dysfunction in pediatric intensive care using PELOD-2

Shenoy,

Patil

2024

J Emerg Pract Trauma

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Objective: Organ dysfunction is an important factor determining the severity and outcome of critical illness in children. Organ dysfunction scores are based on the number of organs involved and the severity of dysfunction in each. This study aimed to evaluate organ dysfunction using PELOD-2 in critically ill children. Methods: This prospective observational study included all consecutive critically ill children with organ dysfunction aged one month to 15 years admitted to pediatric intensive care unit of a Ramaiah Medical College Hospital, Bangalore between January 2018 and December 2020. The severity of organ dysfunction was scored using Pediatric logistic organ dysfunction-2 (PELOD-2) and evaluated based on the outcome using SPSS and PASW statistics for Windows version 18.0. The sample size required for the study with 95% confidence level and 10% relative precision was 149 critically ill children. The children were classified based on the presence of single and multiple organ dysfunction. Demographics and laboratory parameters were compared between the two groups using non parametric tests. The factors affecting mortality among children with multiple organ dysfunction were assessed using univariate and multivariate analysis. Results: Of the 550 children admitted with critical illness during the study period, organ dysfunction was present in 84% of the patients. Of these, 43% had multiple-organ dysfunction. The median (interquartile range) of the patients was 5.5 (1, 11) years with a male-to-female ratio of 1.7:1. The mortality rate was 14.4%. The PELOD-2 score and mortality steadily increased with the number of organs involved. The presence of more than two organ dysfunctions had an odd ratio (OR) of 45.7 for mortality (95% CI: 18.9–110.6, P value<0.001). The area under the receiver operating curve (ROC) for predicting mortality using the number of organs affected was 0.96 (95% CI: 0.94–0.97, P value<0.001). Dysfunction in more than two organs had a sensitivity of 92.5% and a specificity of 91% in predicting mortality. The presence of cardiovascular dysfunction and the need for ventilation were found to be independent predictors of mortality. Conclusion: The presence of more than two organ dysfunctions in PELOD-2 increased the risk of mortality; the need for ventilation and the presence of cardiovascular dysfunction were independent predictors of mortality.

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Comparison between paediatric risk of mortality III and paediatric logistic organ dysfunction-2 as mortality predictor in paediatric intensive care

Cited by 2 publications

References 16 publications

Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio as Predictors of Disease Severity and Mortality in Critically Ill Children: A Retrospective Cohort Study

Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio as Predictors of Disease Severity and Mortality in Critically Ill Children: A Retrospective Cohort Study

Severity of organ dysfunction in pediatric intensive care using PELOD-2

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