Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a Monte Carlo study

Jung, Jin‐Woo; Yoon, Do-Kun; Barraclough, B; Lee, Heui Chang; Suh, Tae Suk; Lü, Bo

doi:10.18632/oncotarget.15700

Cited by 29 publications

(28 citation statements)

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“…The two MC tools obtained almost 90% increase in (n, α) reaction rate, when the depth increases 70%. www.nature.com/scientificreports www.nature.com/scientificreports/ 6 to 400) have been calculated precisely according to the two spectra and the corresponding results have been presented as follow; 100 ppm of 11 B in the tumor with 1.5 cm 3 , leads to the values of = × n B ( ) 9 10 11 18 . The total kinetic energy of the fusion alpha particles in B P ( , )…”

Section: Evaluation Of the P-bftmentioning

confidence: 99%

“…In addition to using the radionuclide as an internal radiation source for treatment of tumors in nuclear medicine, there are other kinds of modalities existent based on radiation arising from external sources 1 . These modalities are X-ray from medical electron accelerators, gamma-knife using gamma-ray 2 , boron neutron capture therapy (BNCT) [3][4][5][6][7][8] involving thermal neutrons and ion therapy or hadron therapy using ions like carbon and the proton [9][10][11][12][13][14][15][16][17][18] . In BNCT (which is currently being investigated), the stable isotope of boron 10 B readily captures neutrons, while the 11 B isotope does not.…”

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confidence: 99%

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Enhancement of Radiation Effectiveness in Proton Therapy: Comparison Between Fusion and Fission Methods and Further Approaches

Tabbakh

Hosmane

2020

Sci Rep

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Proton therapy as a promising candidate in cancer treatment has attracted much attentions and many studies have been performed to investigate the new methods to enhance its radiation effectiveness. In this regard, two research groups have suggested that using boron isotopes will lead to a radiation effectiveness enhancement, using boron-11 agent to initiate the proton fusion reaction (P-BFT) and using boron-10 agent to capture the low energy secondary neutrons (NCEPT). Since, these two innovative methods have not been approved clinically, they have been recalculated in this report, discussed and compared between them and also with the traditional proton therapy to evaluate their impacts before the experimental investigations. The calculations in the present study were performed by Geant4 and MCNPX Monte Carlo Simulation Codes were utilized for obtaining more precision in our evaluations of these methods impacts. Despite small deviations in the results from the two MC tools for the NCEPT method, a good agreement was observed regarding the delivered dose rate to the tumor site at different depths while, for P-BFT related calculations, the GEANT4 was in agreement with the analytical calculations by means of the detailed cross-sections of proton-11 B fusion. Accordingly, both the methods generate excess dose rate to the tumor several orders of magnitude lower than the proton dose rate. Also, it was found that, the P-BFT has more significant enhancement of effectiveness, when compared to the NCEPT, a method with impact strongly depended on the tumor's depth. On the other hand, the advantage of neutron risk reduction proposed by NCEPT was found to give no considerable changes in the neutron dose absorption by healthy tissues.

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Section: Evaluation Of the P-bftmentioning

confidence: 99%

mentioning

confidence: 99%

Enhancement of Radiation Effectiveness in Proton Therapy: Comparison Between Fusion and Fission Methods and Further Approaches

Tabbakh

Hosmane

2020

Sci Rep

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“…In February 2017, Jung et al compared PBFT with boron neutron capture therapy (BNCT) by MC simulation. 5 The energy range was 75-85 MeV with 1-MeV steps. The concentration of the boron was 1•04 mg/g.…”

Section: Introductionmentioning

confidence: 99%

Is the proton–boron fusion therapy effective?

et al. 2020

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Introduction: In the recent years, some publications (mainly from one group of authors) have dealt with the effectiveness of proton–boron fusion therapy (PBFT). This theory is based on the Q-value of three produced α particles in the reaction of protons with boron (11B). They claim that this reaction significantly increases the absorbed dose in the target volume. However, the current study would re-evaluate their method to show if PBFT is really effective. Methods and materials: A parallel 80-MeV proton beam was irradiated on a water medium in a cubic boron uptake region (BUR). The two-dimensional dose distribution and percentage depth dose of protons, alphas and all particles were calculated using tally F6 and mesh-tallies by Monte Carlo N Particle Transport code. Results: The results not only showed that the dose enhancement in BUR is neglectable but also the higher density of BUR in comparison with water led to decrement of dose in this region. Because of low cross section of boron for proton beam (<100 mb), the α particles’ dose is 1,000 times lower than the proton dose. Conclusions: The physical aspects and the simulation results did not show any effectiveness of the PBFT for proton therapy dose enhancement.

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“…Also, obtaining only a low energy spectrum of neutrons (below 10 keV to protect healthy tissues) can be quite challenging, and specific equipment has been designed that might only be adequate for superficial tumors (10 cm deep). Recent approaches suggest that proton and carbon ion beams could also be used to produce epithermal neutrons at the site of boron capture within the tumor (76–80). Thus, the need for specific neutron therapy machines, which are likely inadequate for the treatment of deep-seated tumors, might be surpassed by the use of proton and carbon ion accelerators.…”

Section: Hypoxia From the Radiation Oncologist's Point Of Viewmentioning

confidence: 99%

Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma

et al. 2019

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Severe hypoxia [oxygen partial pressure (pO 2 ) below 5–10 mmHg] is more frequent in glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the 1950s demonstrated that hypoxia was associated with increased resistance to low–linear energy transfer (LET) ionizing radiation. In experimental conditions, the total radiation dose has to be multiplied by a factor of 3 to achieve the same cell lethality in anoxic situations. The presence of hypoxia in human tumors is assumed to contribute to treatment failures after radiotherapy (RT) in cancer patients. Therefore, a logical way to overcome hypoxia-induced radioresistance would be to deliver substantially higher doses of RT in hypoxic volumes delineated on pre-treatment imaging as biological target volumes (BTVs). Such an approach faces various fundamental, technical, and clinical challenges. The present review addresses several technical points related to the delineation of hypoxic zones, which include: spatial accuracy, quantitative vs. relative threshold, variations of hypoxia levels during RT, and availability of hypoxia tracers. The feasibility of hypoxia imaging as an assessment tool for early tumor response to RT and for predicting long-term outcomes is discussed. Hypoxia imaging for RT dose painting is likewise examined. As for the radiation oncologist's point of view, hypoxia maps should be converted into dose-distribution objectives for RT planning. Taking into account the physics and the radiobiology of various irradiation beams, preliminary in silico studies are required to investigate the feasibility of dose escalation in terms of normal tissue tolerance before clinical trials are undertaken.

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Comparison between proton boron fusion therapy (PBFT) and boron neutron capture therapy (BNCT): a Monte Carlo study

Cited by 29 publications

References 20 publications

Enhancement of Radiation Effectiveness in Proton Therapy: Comparison Between Fusion and Fission Methods and Further Approaches

Enhancement of Radiation Effectiveness in Proton Therapy: Comparison Between Fusion and Fission Methods and Further Approaches

Is the proton–boron fusion therapy effective?

Hypoxia Imaging and Adaptive Radiotherapy: A State-of-the-Art Approach in the Management of Glioma

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