Background: In urology, the most common disorder is represented as renal stones. Renal stones have 10% of humans reporting complaints. Their recurrence rate is very high, exhibiting approximately 70 percent recurrence rate. There have been significant advancements made in the treatment of renal stones. PCNL can be used in situations where renal stones are between 10-20 millimeters in the lower pole of a kidney and larger than 20 millimeters. Objective: This study was performed to compare the outcomes of S-PCNL and M-PCNL while treating renal calculi. Study design: A randomized control trial Place and Duration This study was conducted in Karachi Institute of Kidney Diseases Karachi from February 2022 to February 2023 Methodology: There were a total of 50 people included in this research who were equally divided into 2 groups. All of the participants were having a single unilateral renal stone which was <3cm in size. All of the included people were aged 18 years or older. Each patient underwent a physical examination as well as laboratory investigations which included urine culture, CBC, liver function, urinalysis, coagulation profile, and kidney function. There were certain imaging studies that included pelvic and abdominal ultrasonography, kidney–urinary bladder X-ray (KUB), and either intravenous pyelography (IVP) or computed tomography urinary tract (CTUT).