Comparison between Stereo Angiographic Findings and Histopathologic Findings in Endotoxin-Induced Uveitis

Miyashita, Hiroaki; Tagawa, Shigeki; Takeda, Hisashi; Higashide, Tomomi; Sugiyama, Kazuhisa

doi:10.1080/02713680902936163

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…Finally, stereo angiography was previously used in rats to visualize uveitis lesions in the retina and choroid in three dimensions. 26 In our study, stereo ICGA was also used for the successful three-dimensional observation of eyes in which OSSN had regressed.…”

Section: Figurementioning

confidence: 98%

Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia

Sun¹,

Hua²

2020

DDDT

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Purpose To investigate the effectiveness and safety of subconjunctival/perilesional 5-fluorouracil injections on ocular surface squamous neoplasia (OSSN) during a 3-year follow-up period. Patients and Methods We followed up six patients with intraepithelial OSSN (in one eye each) that had regressed after subconjunctival/perilesional 5-fluorouracil injections. Conjunctival fluorescein angiography (FA) and indocyanine green angiography (ICGA), as well as anterior segment optical coherence tomography (AS-OCT), were performed to evaluate the OSSN status 3 years after initiation of treatment. Results The mean age of patients (five males, one female) at baseline was 62.3±11.6 years. The mean number of 5-fluorouracil injections was 17.0±8.6, with a mean treatment duration of 13.0±7.4 weeks. At the final visit, both intratumoral and conjunctival feeding vessels had disappeared on ICGA and FA, with no neovascularization-related leakage, in accordance with the results of AS-OCT. The period from complete tumor regression to final visit according to AS-OCT was 32.5±4.2 months, which was longer than that according to ICGA (31.3±3.2 months, p=0.034). The final best-corrected visual acuity was similar to that at baseline (p=0.128). No side effects were observed in any of the eyes. Conclusion Subconjunctival/perilesional 5-fluorouracil injections are an effective and safe treatment for OSSN. Future studies with a larger sample size are warranted for confirmation of our findings, as well as investigation into the reasons for residual areas of non-perfusion in the conjunctiva.

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Section: Figurementioning

confidence: 98%

Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia

Sun¹,

Hua²

2020

DDDT

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“…The anterior chamber is filled with polymorphonuclear cells and protein indicating vascular endothelial damage observed after 24 to 48 hours. Endotoxin also induces acute exudation and infiltrates in the retinal nerve fiber layer and activation of retinal pigment epithelial cells [104,109]. The underlying choriocapillaris shows early involvement by facilitating rolling and adhesion of recombinant P-selectin glycoprotein ligand-Ig-coated microspheres to the choroidal endothelium [110].…”

Section: Endotoxin-induced Uveitismentioning

confidence: 99%

“…Susceptible strains are Lewis, Sprague-Dawley, Brown-Norway, Wistar [104][105][106] as well as many other strains. Due to the immediate onset and the nature of the molecule, which is derived from bacteria, it is regarded as a model for postinfectious acute anterior uveitis in humans [107].…”

Section: Endotoxin-induced Uveitismentioning

confidence: 99%

Uveitis in Horses, Rats and Man: What Do We Learn from Our Pets?

Deeg¹,

Wildner²,

Thurau

2011

CIR

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The rat model of experimental autoimmune uveitis (EAU) is well established and has served for the development of new therapies in human uveitis. Uveitis in rats can be induced with a number of different autoantigens or peptides, while EAU in mice is only inducible with interphotoreceptor retinoid-binding protein (IRBP) or a single peptide of IRBP. For a long time the rat model was regarded as acute and monophasic, thus therapeutic interventions had to precede the induction of the disease by immunization or adoptive transfer of activated, autoantigen-specific T cells. Only recently spontaneous relapsing-remitting disease, induced with a peptide derived from IRBP, was detected in rats. Some years ago we have introduced the horse as a new animal model for uveitis: horses frequently have spontaneous uveitis (Equine Recurrent Uveitis, ERU) and will also develop the disease after immunization with retinal autoantigens. This offers the opportunity to directly compare spontaneous and induced diseases in the same species, which show high identities. Comparing different species, we found similarities between horses, rats, mice and humans with respect to the antigen-specificity of T cell responses, course of disease and histology. Proteomics of healthy and diseased equine eyes offered an insight of intraocular alterations during inflammation, which might be representative for uveitis in general.

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Comparison between Stereo Angiographic Findings and Histopathologic Findings in Endotoxin-Induced Uveitis

Abstract: Stereo angiography was considered useful for three-dimensional analysis of uveitis lesions in the retina and choroid.

Cited by 2 publications

References 12 publications

Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia

Long-Term Efficacy and Safety of Subconjunctival/Perilesional 5-Fluorouracil Injections for Ocular Surface Squamous Neoplasia

Uveitis in Horses, Rats and Man: What Do We Learn from Our Pets?

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