Comparison between tamoxifen and clomiphene citrate for induction of ovulation and successful conception in polycystic ovarian syndrome

Hassan, Zhyan Baker

doi:10.18203/2320-1770.ijrcog20150709

Cited by 2 publications

(2 citation statements)

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“…Tx has a suitable effect on the cervical mucus, endometrium, and better functioning of the corpus luteum (Dhaliwal et al, 2011). Therefore, this drug may be a good alternative for the successful induction of higher ovulation in women with PCO who fail ovulate with CC (Dhaliwal et al, 2011; Hassan, 2015; Jie et al, 2018; Kishk, 2018). Aref et al suggested that co‐treatment of low‐dose aspirin (LDA) with Tx as an effective, cheap, and safe protocol enhanced ovarian stimulation, endometrial thickness, and pregnancy rates in patients with PCOS (Aref, Ahmed, Ahmed, & Sedik, 2019).…”

Section: Oogenesis Stimulator Drugsmentioning

confidence: 99%

Mini review: The FDA‐approved prescription drugs that induce ovulation in women with ovulatory problems

Sun

Rong

Cai

et al. 2020

Drug Development Research

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Infertility is defined as not being able to become pregnant after 12 months or more of unprotected sexual intercourse. Female infertility as a serious health issue can result from ovulation disorders, menstrual cycle problems, structural problems, and environmental factors. Ovulation occurs once a month between the time of menarche and menopause. The release of a mature egg from the ovary is controlled with the hypothalamic‐pituitary‐ovarian axis. Several hormones such as gonadotropin‐releasing hormone (GnRH), FSH (follicle‐stimulating hormone), LH (luteinizing hormone), estrogen, and progesterone play fundamental roles in the ovulation process. Both FSH and LH are the main treatment for women with ovulation disorders. Depending on the reasons for infertility, several different types of treatment are available for infertile women. Fertility drugs as an important part of treatment work like the natural hormones to treat infertility. Several fertility drugs can regulate ovulation and the release of an egg from the ovary in women with polycystic ovary syndrome (PCOS) or undergoing in vitro fertilization (IVF) treatment. This mini‐review is about the FDA‐approved prescription drugs that induce ovulation in women with ovulatory problems.

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Section: Oogenesis Stimulator Drugsmentioning

confidence: 99%

Mini review: The FDA‐approved prescription drugs that induce ovulation in women with ovulatory problems

Sun

Rong

Cai

et al. 2020

Drug Development Research

View full text Add to dashboard Cite

show abstract

“…Anovulation is one of the major causes of reproductive failure in sub-fertile and infertile women [6,7]. In the absence of other reproductive problems, successful ovulation induction and good quality oocyte often restores normal fertility in human [8].…”

Section: Introductionmentioning

confidence: 99%

Clomiphene Citrate and Oocyte Quality

Sk¹

2017

GJORM

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The clomiphene citrate (CC) is a first line of medicine used for ovulation induction in women worldwide. CC has good ovulation induction ability in anovulatory women but the pregnancy rate is very poor. This discrepancy might be due to the anti-estrogenic effect of CC at various level including ovary and oocytes. The hypoestrogenic conditions due to CC treatment inhibit follicular growth and development, induce susceptibility of oocytes towards apoptosis and deteriorate oocyte quality after ovulation. CC induces reactive oxygen species (ROS) mediated granulosa cells as well as oocyte apoptosis within the follicle of the ovary. Apoptosis deteriorates oocyte quality and thereby reproductive outcome. Supplementation of estradiol 17β or natural antioxidant such as melatonin prevents anti-estrogenic effects of CC and improves oocyte quality by scavenging CC induced generation of ROS. Thus, we propose that the supplementation of estradiol 17β and/or melatonin along with CC may be beneficial to overcome the anti-estrogenic effect of CC during infertility management in human.

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Comparison between tamoxifen and clomiphene citrate for induction of ovulation and successful conception in polycystic ovarian syndrome

Cited by 2 publications

References 8 publications

Mini review: The FDA‐approved prescription drugs that induce ovulation in women with ovulatory problems

Mini review: The FDA‐approved prescription drugs that induce ovulation in women with ovulatory problems

Clomiphene Citrate and Oocyte Quality

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