Comparison between the effect of silymarin and silver sulfadiazine on burned wound healing in rats

Abstract

A burn is an injury caused by transfer of thermal energy into tissue resulting in disruption of its normal anatomical structure. An experiment was carried out to compare the effect of silymarin and silver sulfadiazine on burned wound healing in rat. In this study, 36 Wistar rats were divided into 6 groups. A burn was generated on the backs of all rats by brass probe. The burned areas in the first group (control) did not receive any medication, the second group received oral silymarin. Wound areas in third, fourth and fifth group were covered daily with 5%, 10% and 20% silymarin ointment. Silver sulfadiazine was applied as daily topical treatment of burned wound in the sixth group. At post injury days 0, 5, 7, 14 and 21, rats from each group were selected, sacrificed and burned skin tissue samples were collected for histopathological examination. Ulceration, acute inflammation, chronic inflammation, crust formation and granulation tissue formation were assessed. The result of this study showed that the use of 10% silymarin significantly enhanced the burn wound healing process as compared to silver sulfadiazine and other silymarin concentrations.

Bio-Evaluation of the Wound Healing Activity of Artemisia judaica L. as Part of the Plant’s Use in Traditional Medicine; Phytochemical, Antioxidant, Anti-Inflammatory, and Antibiofilm Properties of the Plant’s Essential Oils

“…Wound healing is a complex restorative process of injured tissue to its original state [ 87 ], and it involves hemostasis, inflammation, proliferation, and remodeling [ 88 ] to prevent complex metabolic alteration affecting body organ systems. During the process of hemostasis, blood coagulation occurs, while the inflammation process ensures safety from invasive pathogens [ 88 ], thereby facilitating the proliferation step [ 89 ] towards remodeling the tissue maturation process [ 89 , 90 ].…”

“…During the process of hemostasis, blood coagulation occurs, while the inflammation process ensures safety from invasive pathogens [ 88 ], thereby facilitating the proliferation step [ 89 ] towards remodeling the tissue maturation process [ 89 , 90 ]. During skin burn, cells and tissues are damaged substantially, thereby involving a complicated healing network compared to wound incision [ 87 ]. Based on the deepness of the burn wounds, they are categorized as first-, second-, and third-degree burns.…”

The Role of Silver Nanoparticles on Accelerating Healing of Skin Wounds in Rats: Histological and Immunohistochemical Study

“…14 Group III (SSD treated group): rats of this group were topically treated once daily with SSD (dermazine cream) at a dose of 30 mg/kg/b.w. 15 Group IV (AgNps treated group): rats with skin wound were topically treated once daily with AgNps hydrogel at a dose of 2000 mg/kg/b.w. 14…”

Evaluation of wound healing potential of pomegranate (Punica granatum) whole fruit extract on skin burn wound in rats (Rattus norvegicus)

“…Burn wound is one of the most considerable cases in the world [1]. Burn wound creates an extensive loss of cells and tissues, which makes the repair process more complicated than incision wound [2]. On the other hand, burn wound usually comes with complications.…”