“…NT had been used as a standard marker in first trimester screening for Down syndrome, in combination with serum markers. Although Paul et al (2001) reported that NT measurement can be repeated only 60% in a 3D random volume, a number of studies regarding evaluation of NT using 2D and 3D sonography showed a good correlation between these two techniques at any position (Kurjak et al, 1999;Chung et al, 2000;Clementschitsch et al, 2001;Eppel et al, 2001;Michailidis et al, 2002;Worda et al, 2003;Shipp et al, 2006). We also agree with the results published by Shipp et al (2006) that 3D sonography would be potentially useful in scanning fetuses that are not in an optimal position.…”