Comparison between two fat emulsions: Intralipid® 30%vs Intralipid® 10% in critically ill patients

Kalfarentzos, Fotis; Kokkinis, K.; Leukaditi, K.; Maroulis, John; Onoufriou, A.; Alexopoulos, K.

doi:10.1016/s0261-5614(98)80040-x

Cited by 19 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this reason, 20% SOFE is preferred over 10% SOFE as an IVFE source in low‐birth‐weight infants. Similar differences were seen in a study comparing different concentrations of SOFE in critically ill adults 59 . Patients who received a 30% emulsion had lower plasma levels of triglycerides, phospholipids, and free cholesterol than those who received the 10% SOFE.…”

Section: Oil Sources: Impact On Clearancesupporting

confidence: 74%

Intravenous Fat Emulsion Formulations for the Adult and Pediatric Patient

et al. 2016

View full text Add to dashboard Cite

Intravenous lipid emulsions (IVLE) provide essential fatty acids (FA) and are a dense source of energy in parenteral nutrition (PN). Parenterally administered lipid was introduced in the 17th century but plagued with side effects. The formulation of lipid emulsions later on made it a relatively safe component for administration to patients. Many ingredients are common to all IVLE, yet the oil source(s) and its (their) percentage(s) makes them different from each other. The oil used dictates how IVLE are metabolized and cleared from the body. The FA present in each type of oil provide unique beneficial and detrimental properties. This review provides an overview of IVLE and discuss factors that would help clinicians choose the optimal product for their patients. Elucidating the characteristics of each oil source over time has resulted in an evolution of the different formulations currently available. Emulsions have gone from being solely made with soybean oil, to being combined with medium-chain triglycerides (i.e., coconut oil), olive oil, and more recently, fish oil. Unfortunately, the lipid, among other constituents in PN formulations, has been associated with the development of liver disease. Lipid-sparing or lipid-reduction strategies have therefore been proposed to avoid these complications. The ideal IVLE would reverse or prevent essential FA deficiency without leading to complications, while simultaneously providing energy to facilitate normal growth and development. Modifications in their ingredients, formulation, and dosing have made IVLE a relatively safe component alone or when added to PN formulations. The ideal emulsion, however, has yet to be developed.

show abstract

Section: Oil Sources: Impact On Clearancesupporting

confidence: 74%

Intravenous Fat Emulsion Formulations for the Adult and Pediatric Patient

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Thus, we demonstrated the relationship between stress and blood lipid metabolism using Intralipid ® as a tracer for the simple fat emulsion clearance test in mice exposed to restraint stress. Intralipid ® , an artificial lipid emulsion used to supply energy and essential fatty acids, is commonly used in clinical practice (17) and also as a tracer for blood triglyceride (18).…”

Section: Introductionmentioning

confidence: 99%

Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Yao

Wang

et al. 2009

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. The present study was conducted to investigate the effects of histamine on the lipid metabolic disorder in mice loaded with restraint stress. When Kun Ming (KM) mice were exposed to restraint stress for 20 h, the histamine level in both plasma and cerebral regions significantly increased (P<0.01). Moreover, when a lipid emulsion (10% Intralipid ® ) was injected intravenously into the mice, the elimination period of plasma triglyceride was prolonged in the restraint group. Plasma triglyceride was 523 ± 44 mg/dl at 35 min after the Intralipid ® administration in the restraint stress group, while it was 436 ± 41 mg/dl in the restrained mice given histamine at a dose of 50 mg/kg. The improved plasma triglyceride metabolism was well explained by the observations of the significantly up-regulated hepatic triglyceride lipase (HTGL) activity and mRNA expression in response to histamine. These results suggested that the effects of stress-induced histamine on lipid metabolic disorder in mice loaded with restraint stress arose from its anti-stress action and promotion of lipase activity.

show abstract

“…The authors suggest that this may be due to the lower phospholipid/triglyceride ratio in the former emulsion, with both lipid emulsions showing similar results with respect to tolerance and safety (Garcia de Lorenzo et al, 2003). Kalfarentzos et al (1998) observed similar results.…”

Section: Implementation Of Nutrition Care Planmentioning

confidence: 94%

Current practices in the delivery of parenteral nutrition in Australia

2006

View full text Add to dashboard Cite

Objective: To determine current practice in the delivery of parenteral nutrition (PN) in Australian hospitals. Design: A cross-sectional mail survey. Setting: Acute-care adult hospitals with greater than 200 beds in Australia. Subjects: A total of 67 hospitals (65.7% response rate). Intervention: Surveys were posted to hospitals. A reminder letter with a second copy of the survey was posted 3 weeks later to non-respondents. Results: Twenty-seven (40.3%) of the hospitals have a PN team and 50 (74.6%) have a hospital protocol for PN delivery. An inaccessible or non-functional gastrointestinal tract is the most common indicator for commencing PN. Fat infusion is calculated by 24 (38.7%) respondents with a mean (s.d.) maximum amount of fat provided of 2.0 (0.7) g/kg/day. Over half (n ¼ 35) reported calculating carbohydrate infusion at a maximum amount of 5.4 (1.0) mg/kg/min. Two-thirds (n ¼ 41) reported commencing PN at a rate of 50% or less of goal rate. Blood glucose levels (BGL) were monitored at least once per day by the majority of respondents (n ¼ 56, 83.6%). Insulin infusion was commenced at varying BGL. Most respondents (n ¼ 40, 59.7%) reported ceasing PN when at least half of the patient's requirements are being met either orally or enterally. A number of practice guidelines were identified and the results of the survey were compared with these guidelines. Conclusions: Where there are clear practice guidelines, current practice appears to be in line with these recommendations, however, where evidence is lacking, practice is varied.

show abstract

Comparison between two fat emulsions: Intralipid® 30%vs Intralipid® 10% in critically ill patients

Cited by 19 publications

References 18 publications

Intravenous Fat Emulsion Formulations for the Adult and Pediatric Patient

Intravenous Fat Emulsion Formulations for the Adult and Pediatric Patient

Effects of Histamine on Lipid Metabolic Disorder in Mice Loaded With Restraint Stress

Current practices in the delivery of parenteral nutrition in Australia

Contact Info

Product

Resources

About