Comparison between two preventive treatments for hyperketonaemia carried out <i>pre-partum</i>: effects on non-esterified fatty acids, β-hydroxybutyrate and some biochemical parameters during peripartum and early lactation

Fiore, Enrico; Perillo, Laura; Gianesella, Matteo; Giannetto, Claudia; Giudice, Elisabetta; Piccione, Giuseppe; Morgante, Massimo

doi:10.1017/s0022029921000108

Cited by 10 publications

(12 citation statements)

References 33 publications

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“…Conversely, the effect of monensin CRC on NEFA and glucose levels is less robust. As also confirmed by a recent paper [34], lower levels of NEFA and higher levels of glucose are frequently reported in CRC-treated cows. On the contrary, other studies report no significant effects on these variables.…”

Section: Metabolism and Healthsupporting

confidence: 79%

“…The same observations are made relative to loss of body condition. Three studies enrolling 1010, 136 and 100 cows, respectively [24,34,50] highlighted a reduced loss of body condition in treated animals after calving, which was associated with their lower BHB levels and confirm their better energy balance. On the contrary, another study, with 168 cows, did not find a significant difference in body condition, despite a lower production of ketone bodies of treated cows [40].…”

Section: Metabolism and Healthmentioning

confidence: 91%

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The Use of Monensin for Ketosis Prevention in Dairy Cows during the Transition Period: A Systematic Review

Mammi

Guadagnini

Mechor

et al. 2021

Animals

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Since the approval by the European Medicines Agency in 2013 of a monensin controlled-release capsule (CRC) for the prevention of ketosis in dairy cows, there has been widespread use across Europe. In recent decades, several papers have investigated the effects of monensin used as a CRC or as a feed additive to improve cattle energy metabolism and improve feed efficiency. Since the CRC is the only form of monensin permitted in Europe in dairy cows, the objective of this review was to report and summarize observations from the literature on the effects of this treatment in transition cows. The peer-reviewed literature published from 1997 was scanned, and papers written in English were evaluated for eligibility. Only papers evaluating the use of monensin in dairy cows for the prevention of ketosis during the transition period were reviewed. In total, 42 papers met the required criteria and were included in this review. The major findings focused on cow metabolism and health, rumen fermentation and milk production and quality. Overall, the review of the existing literature confirmed that monensin delivered as a CRC during the transition period has effects of different magnitude compared to other forms, doses or durations of administration. Studies agree on the antiketotic effects of this treatment, showing evidence of an increased propionate production in the rumen, reduced blood β-hydroxybutyrate, and improved liver function in treated cows, mainly resulting in reduced incidence of peripartum disease. On the contrary, the effects of CRC on ammonia production and rumen microflora are less robust than those reported for other forms. Of importance for the European market is the well-documented absence of any negative impact on milk and cheese production and composition using the CRC treatment.

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Section: Metabolism and Healthsupporting

confidence: 79%

Section: Metabolism and Healthmentioning

confidence: 91%

The Use of Monensin for Ketosis Prevention in Dairy Cows during the Transition Period: A Systematic Review

Mammi

Guadagnini

Mechor

et al. 2021

Animals

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“…Although the driving cause of immune dysfunctions occurring during the late gestation phase remains unclear, negative effects of these on the metabolism of early lactating cows depend on several potentially harmful stimuli occurring during the TP-these may have additive effects. Some of these stimuli are driven by physiological changes occurring in the metabolism of dairy cows around the calving time: repolarization of the immune cells to maintain the pregnancy status, as well as alterations to hormonal patterns, nutrient availability, and redox balance [2,4,[52][53][54][55]. Others are driven by psychological factors related to regrouping procedures adopted around the calving time [42].…”

Section: Distressing Events Accrue the Severity Of Immune And Metabol...mentioning

confidence: 99%

The Transition Period Updated: A Review of the New Insights into the Adaptation of Dairy Cows to the New Lactation

Mezzetti

Cattaneo

Passamonti

et al. 2021

Dairy

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Recent research on the transition period (TP) of dairy cows has highlighted the pivotal role of immune function in affecting the severity of metabolic challenges the animals face when approaching calving. This suggests that the immune system may play a role in the etiology of metabolic diseases occurring in early lactation. Several studies have indicated that the roots of immune dysfunctions could sink way before the “classical” TP (e.g., 3 weeks before and 3 weeks after calving), extending the time frame deemed as “risky” for the development of early lactation disorders at the period around the dry-off. Several distressing events occurring during the TP (i.e., dietary changes, heat stress) can boost the severity of pre-existing immune dysfunctions and metabolic changes that physiologically affect this phase of the lactation cycle, further increasing the likelihood of developing diseases. Based on this background, several operational and nutritional strategies could be adopted to minimize the detrimental effects of immune dysfunctions on the adaptation of dairy cows to the new lactation. A suitable environment (i.e., optimal welfare) and a balanced diet (which guarantees optimal nutrient partitioning to improve immune functions in cow and calf) are key aspects to consider when aiming to minimize TP challenges at the herd level. Furthermore, several prognostic behavioral and physiological indicators could help in identifying subjects that are more likely to undergo a “bad transition”, allowing prompt intervention through specific modulatory treatments. Recent genomic advances in understanding the linkage between metabolic disorders and the genotype of dairy cows suggest that genetic breeding programs aimed at improving dairy cows’ adaptation to the new lactation challenges (i.e., through increasing immune system efficiency or resilience against metabolic disorders) could be expected in the future. Despite these encouraging steps forward in understanding the physiological mechanisms driving metabolic responses of dairy cows during their transition to calving, it is evident that these processes still require further investigation, and that the TP—likely extended from dry-off—continues to be “the final frontier” for research in dairy sciences.

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“…During the transition period, the higher nutrient demands for fetal growth and milk production cause important metabolic adjustments to support energy requirements 1 , 2 . In parallel, a reduction in dry matter intake is established (DMI), leading to a negative energy balance (NEB) 3 .…”

Section: Introductionmentioning

confidence: 99%

Differences in the serum metabolome profile of dairy cows according to the BHB concentration revealed by proton nuclear magnetic resonance spectroscopy (1H-NMR)

Lisuzzo

Laghi

Faillace

et al. 2022

Sci Rep

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The mobilization of body reserves during the transition from pregnancy to lactation might predispose dairy cows to develop metabolic disorders such as subclinical ketosis or hyperketonemia. These conditions are not easily identifiable and are frequently related to other diseases that cause economic loss. The aim of this study was to evaluate the serum metabolome differences according to the β-hydroxybutyrate (BHB) concentration. Forty-nine Holstein Friesian dairy cows were enrolled between 15 and 30 days in milk. According to their serum BHB concentration, the animals were divided into three groups: Group 0 (G0; 12 healthy animals; BHB ≤ 0.50 mmol/L); Group 1 (G1; 19 healthy animals; 0.51 ≤ BHB < 1.0 mmol/L); and Group 2 (G2; 18 hyperketonemic animals; BHB ≥ 1.0 mmol/L). Animal data and biochemical parameters were examined with one-way ANOVA, and metabolite significant differences were examined by t-tests. Fifty-seven metabolites were identified in the serum samples. Thirteen metabolites showed significant effects and seemed to be related to the mobilization of body reserves, lipids, amino acid and carbohydrate metabolism, and ruminal fermentation.

show abstract

Comparison between two preventive treatments for hyperketonaemia carried out pre-partum: effects on non-esterified fatty acids, β-hydroxybutyrate and some biochemical parameters during peripartum and early lactation

Cited by 10 publications

References 33 publications

The Use of Monensin for Ketosis Prevention in Dairy Cows during the Transition Period: A Systematic Review

The Use of Monensin for Ketosis Prevention in Dairy Cows during the Transition Period: A Systematic Review

The Transition Period Updated: A Review of the New Insights into the Adaptation of Dairy Cows to the New Lactation

Differences in the serum metabolome profile of dairy cows according to the BHB concentration revealed by proton nuclear magnetic resonance spectroscopy (1H-NMR)

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